Histidine triad nucleotide-binding protein 1

NameHistidine triad nucleotide-binding protein 1
Synonyms
  • 3.-.-.-
  • Adenosine 5'-monophosphoramidase
  • HINT
  • PKCI-1
  • PKCI1
  • PRKCNH1
  • Protein kinase C inhibitor 1
  • Protein kinase C-interacting protein 1
Gene NameHINT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016443|Histidine triad nucleotide-binding protein 1
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHI
SQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQ
MHWPPG
Number of residuesNone
Molecular Weight13801.815
Theoretical pI6.96
GO Classification
Functions
  • hydrolase activity
  • nucleotide binding
  • protein kinase C binding
Processes
  • transcription, DNA-templated
  • intrinsic apoptotic signaling pathway by p53 class mediator
  • signal transduction
  • purine ribonucleotide catabolic process
  • regulation of transcription, DNA-templated
  • positive regulation of calcium-mediated signaling
Components
  • histone deacetylase complex
  • cytoplasm
  • cytoskeleton
  • nucleus
  • plasma membrane
  • extracellular exosome
General FunctionProtein kinase c binding
Specific FunctionHydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP49773
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016444|Histidine triad nucleotide-binding protein 1 (HINT1)
ATGGCAGATGAGATTGCCAAGGCTCAGGTCGCTCGGCCTGGTGGCGACACGATCTTTGGG
AAGATCATCCGCAAGGAAATACCAGCCAAAATCATTTTTGAGGATGACCGGTGCCTTGCT
TTCCATGACATTTCCCCTCAAGCACCAACACATTTTCTGGTGATACCCAAGAAACATATA
TCCCAGATTTCTGTGGCAGAAGATGATGATGAAAGTCTTCTTGGACACTTAATGATTGTT
GGCAAGAAATGTGCTGCTGATCTGGGCCTGAATAAGGGTTATCGAATGGTGGTGAATGAA
GGTTCAGATGGTGGACAGTCTGTCTATCACGTTCATCTCCATGTTCTTGGAGGTCGGCAA
ATGCATTGGCCTCCTGGTTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location5
Locus5q31.2
References
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