Macrophage migration inhibitory factor

NameMacrophage migration inhibitory factor
Synonyms
  • 5.3.2.1
  • GIF
  • GLIF
  • Glycosylation-inhibiting factor
  • L-dopachrome isomerase
  • L-dopachrome tautomerase
  • MIF
  • MMIF
  • Phenylpyruvate tautomerase
Gene NameMIF
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020563|Macrophage migration inhibitory factor
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Number of residuesNone
Molecular Weight12476.19
Theoretical pI8.05
GO Classification
Functions
  • receptor binding
  • cytokine activity
  • chemoattractant activity
  • cytokine receptor binding
  • dopachrome isomerase activity
  • phenylpyruvate tautomerase activity
Processes
  • protein homotrimerization
  • positive regulation of protein kinase A signaling
  • negative regulation of cell aging
  • positive regulation of arachidonic acid secretion
  • prostaglandin biosynthetic process
  • innate immune response
  • negative regulation of cellular protein metabolic process
  • regulation of macrophage activation
  • negative regulation of myeloid cell apoptotic process
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of lipopolysaccharide-mediated signaling pathway
  • positive regulation of B cell proliferation
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • positive regulation of myeloid leukocyte cytokine production involved in immune response
  • negative regulation of apoptotic process
  • positive chemotaxis
  • negative regulation of mature B cell apoptotic process
  • positive regulation of prostaglandin secretion involved in immune response
  • positive regulation of peptidyl-serine phosphorylation
  • negative regulation of cell cycle arrest
  • inflammatory response
  • positive regulation of chemokine (C-X-C motif) ligand 2 production
  • cell surface receptor signaling pathway
  • negative regulation of DNA damage response, signal transduction by p53 class mediator
  • cell aging
  • carboxylic acid metabolic process
  • positive regulation of MAP kinase activity
  • positive regulation of cytokine secretion
  • cell proliferation
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of fibroblast proliferation
  • negative regulation of gene expression
  • positive regulation of phosphorylation
  • DNA damage response, signal transduction by p53 class mediator
Components
  • cytoplasm
  • nucleoplasm
  • extracellular region
  • extracellular space
  • cell surface
  • vesicle
  • extracellular exosome
  • myelin sheath
General FunctionReceptor binding
Specific FunctionPro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP14174
UniProtKB Entry Name
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020564|Macrophage migration inhibitory factor (MIF)
ATGCCGATGTTCATCGTAAACACCAACGTGCCCCGCGCCTCCGTGCCGGACGGGTTCCTC
TCCGAGCTCACCCAGCAGCTGGCGCAGGCCACCGGCAAGCCCCCCCAGTACATCGCGGTG
CACGTGGTCCCGGACCAGCTCATGGCCTTCGGCGGCTCCAGCGAGCCGTGCGCGCTCTGC
AGCCTGCACAGCATCGGCAAGATCGGCGGCGCGCAGAACCGCTCCTACAGCAAGCTGCTG
TGCGGCCTGCTGGCCGAGCGCCTGCGCATCAGCCCGGACAGGGTCTACATCAACTATTAC
GACATGAACGCGGCCAATGTGGGCTGGAACAACTCCACCTTCGCCTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location22
Locus22q11.23
References
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