Hepatocyte growth factor-regulated tyrosine kinase substrate

NameHepatocyte growth factor-regulated tyrosine kinase substrate
Synonyms
  • HRS
  • Protein pp110
Gene NameHGS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009544|Hepatocyte growth factor-regulated tyrosine kinase substrate
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
Number of residuesNone
Molecular Weight86191.46
Theoretical pINone
GO Classification
Functions
  • protein domain specific binding
  • metal ion binding
Processes
  • endosome to lysosome transport
  • signal transduction
  • endosomal transport
  • membrane invagination
  • positive regulation of gene expression
  • negative regulation of JAK-STAT cascade
  • post-Golgi vesicle-mediated transport
  • regulation of MAP kinase activity
  • regulation of protein catabolic process
  • epidermal growth factor receptor signaling pathway
  • protein targeting to lysosome
  • positive regulation of exosomal secretion
  • negative regulation of epidermal growth factor receptor signaling pathway
  • negative regulation of cell proliferation
  • protein localization to membrane
  • membrane organization
Components
  • cytoplasm
  • endosome
  • multivesicular body membrane
  • early endosome
  • cytosol
  • early endosome membrane
  • extracellular exosome
  • secretory granule
  • intracellular membrane-bounded organelle
General FunctionProtein domain specific binding
Specific FunctionInvolved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO14964
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013223|Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
ATGGGGCGAGGCAGCGGCACCTTCGAGCGTCTCCTAGACAAGGCGACCAGCCAGCTCCTG
TTGGAGACAGATTGGGAGTCCATTTTGCAGATCTGCGACCTGATCCGCCAAGGGGACACA
CAAGCAAAATATGCTGTGAATTCCATCAAGAAGAAAGTCAACGACAAGAACCCACACGTC
GCCTTGTATGCCCTGGAGGTCATGGAATCTGTGGTAAAGAACTGTGGCCAGACAGTTCAT
GATGAGGTGGCCAACAAGCAGACCATGGAGGAGCTGAAGGACCTGCTGAAGAGACAAGTG
GAGGTAAACGTCCGTAACAAGATCCTGTACCTGATCCAGGCCTGGGCGCATGCCTTCCGG
AACGAGCCCAAGTACAAGGTGGTCCAGGACACCTACCAGATCATGAAGGTGGAGGGGCAC
GTCTTTCCAGAATTCAAAGAGAGCGATGCCATGTTTGCTGCCGAGAGAGCCCCAGACTGG
GTGGACGCTGAGGAATGCCACCGCTGCAGGGTGCAGTTCGGGGTGATGACCCGTAAGCAC
CACTGCCGGGCGTGTGGGCAGATATTCTGTGGAAAGTGTTCTTCCAAGTACTCCACCATC
CCCAAGTTTGGCATCGAGAAGGAGGTGCGCGTGTGTGAGCCCTGCTACGAGCAGCTGAAC
AGGAAAGCGGAGGGAAAGGCCACTTCCACCACTGAGCTGCCCCCCGAGTACCTGACCAGC
CCCCTGTCTCAGCAGTCCCAGCTGCCCCCCAAGAGGGACGAGACGGCCCTGCAGGAGGAG
GAGGAGCTGCAGCTGGCCCTGGCGCTGTCACAGTCAGAGGCGGAGGAGAAGGAGAGGCTG
AGACAGAAGTCCACGTACACTTCGTACCCCAAGGCGGAGCCCATGCCCTCGGCCTCCTCA
GCGCCCCCCGCCAGCAGCCTGTACTCTTCACCTGTGAACTCGTCGGCGCCTCTGGCTGAG
GACATCGACCCTGAGCTCGCACGGTATCTCAACCGGAACTACTGGGAGAAGAAGCAGGAG
GAGGCTCGCAAGAGCCCCACGCCATCTGCGCCCGTGCCCCTGACGGAGCCGGCTGCACAG
CCTGGGGAAGGGCACGCAGCCCCCACCAACGTGGTGGAGAACCCCCTCCCGGAGACAGAC
TCTCAGCCCATTCCTCCCTCTGGTGGCCCCTTTAGTGAGCCACAGTTCCACAATGGCGAG
TCTGAGGAGAGCCACGAGCAGTTCCTGAAGGCGCTGCAGAACGCCGTCACCACCTTCGTG
AACCGCATGAAGAGTAACCACATGCGGGGCCGCAGCATCACCAATGACTCGGCCGTGCTC
TCACTCTTCCAGTCCATCAACGGCATGCACCCGCAGCTGCTGGAGCTGCTCAACCAGCTG
GACGAGCGCAGGCTGTACTATGAGGGGCTGCAGGACAAGCTGGCACAGATCCGCGATGCC
CGGGGGGCGCTGAGTGCCCTGCGCGAAGAGCACCGGGAGAAGCTTCGCCGGGCAGCCGAG
GAGGCAGAGCGCCAGCGCCAGATCCAGCTGGCCCAGAAGCTGGAGATAATGCGGCAGAAG
AAGCAGGAGTACCTGGAGGTGCAGAGGCAGCTGGCCATCCAGCGCCTGCAGGAGCAGGAG
AAGGAGCGGCAGATGCGGCTGGAGCAGCAGAAGCAGACGGTCCAGATGCGCGCGCAGATG
CCCGCCTTCCCCCTGCCCTACGCCCAGCTCCAGGCCATGCCCGCAGCCGGAGGTGTGCTC
TACCAGCCCTCGGGACCAGCCAGCTTCCCCAGCACCTTCAGCCCTGCCGGCTCGGTGGAG
GGCTCCCCAATGCACGGCGTGTACATGAGCCAGCCGGCCCCTGCCGCTGGCCCCTACCCC
AGCATGCCCAGCACTGCGGCTGATCCCAGCATGGTGAGTGCCTACATGTACCCAGCAGGG
GCCACTGGGGCGCAGGCGGCCCCCCAGGCCCAGGCCGGACCCACCGCCAGCCCCGCTTAC
TCATCCTACCAGCCTACTCCCACAGCGGGCTACCAGAACGTGGCCTCCCAGGCCCCACAG
AGCCTCCCGGCCATCTCTCAGCCTCCGCAGTCCAGCACCATGGGCTACATGGGGAGCCAG
TCAGTCTCCATGGGCTACCAGCCTTACAACATGCAGAATCTCATGACCACCCTCCCAAGC
CAGGATGCGTCTCTGCCACCCCAGCAGCCCTACATCGCGGGGCAGCAGCCCATGTACCAG
CAGATGGCACCCTCTGGCGGTCCCCCCCAGCAGCAGCCCCCCGTGGCCCAGCAACCGCAG
GCACAGGGGCCGCCGGCACAGGGCAGCGAGGCCCAGCTCATTTCATTCGACTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location17
LocusNone
References
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