N5-carboxyaminoimidazole ribonucleotide mutase

NameN5-carboxyaminoimidazole ribonucleotide mutase
Synonyms
  • 5-(carboxyamino)imidazole ribonucleotide mutase
  • 5.4.99.18
  • N5-CAIR mutase
Gene NamepurE
OrganismAcetobacter aceti
Amino acid sequence
>lcl|BSEQ0012267|N5-carboxyaminoimidazole ribonucleotide mutase
MSETAPLPSASSALEDKAASAPVVGIIMGSQSDWETMRHADALLTELEIPHETLIVSAHR
TPDRLADYARTAAERGLNVIIAGAGGAAHLPGMCAAWTRLPVLGVPVESRALKGMDSLLS
IVQMPGGVPVGTLAIGASGAKNAALLAASILALYNPALAARLETWRALQTASVPNSPITE
DK
Number of residuesNone
Molecular Weight18734.295
Theoretical pI5.6
GO Classification
Functions
  • 5-(carboxyamino)imidazole ribonucleotide mutase activity
Processes
  • 'de novo' IMP biosynthetic process
Components
General Function5-(carboxyamino)imidazole ribonucleotide mutase activity
Specific FunctionCatalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ2QJL3
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0006346|549 bp
GTGAGCGAAACCGCCCCCCTGCCCTCTGCTTCCAGTGCTTTAGAAGATAAAGCAGCCTCT
GCCCCCGTTGTGGGCATTATCATGGGCAGCCAGTCAGACTGGGAAACCATGCGCCATGCA
GACGCATTGCTGACAGAGCTGGAAATTCCGCATGAAACCCTCATTGTTTCAGCACATCGT
ACGCCAGACCGGTTGGCGGATTATGCGCGTACGGCAGCCGAACGCGGCCTGAATGTGATT
ATTGCTGGGGCCGGTGGAGCTGCACATCTGCCGGGTATGTGTGCGGCATGGACACGCCTG
CCCGTGCTGGGTGTTCCAGTAGAATCTCGCGCTCTTAAAGGCATGGACAGCCTGCTTTCC
ATTGTGCAGATGCCCGGCGGCGTGCCTGTGGGCACTTTGGCTATTGGGGCATCCGGCGCC
AAAAATGCCGCCTTGCTGGCCGCCTCCATTCTTGCACTGTATAACCCGGCCCTTGCCGCA
CGCCTTGAAACATGGCGCGCATTGCAGACGGCCTCTGTCCCCAACTCTCCCATTACCGAA
GATAAATGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Settembre EC, Chittuluru JR, Mill CP, Kappock TJ, Ealick SE: Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE). Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1753-60. Epub 2004 Sep 23. [15388921 ]
  2. Constantine CZ, Starks CM, Mill CP, Ransome AE, Karpowicz SJ, Francois JA, Goodman RA, Kappock TJ: Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti. Biochemistry. 2006 Jul 11;45(27):8193-208. [16819818 ]

From www.t3db.ca