50S ribosomal protein L4

Name	50S ribosomal protein L4
Synonyms	TmaL4
Gene Name	rplD
Organism	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence	>lcl\|BSEQ0012268\|50S ribosomal protein L4 MAQVDLLNVKGEKVGTLEISDFVFNIDPNYDVMWRYVDMQLSNRRAGTASTKTRGEVSGG GRKPWPQKHTGRARHGSIRSPIWRHGGVVHGPKPRDWSKKLNKKMKKLALRSALSVKYRE NKLLVLDDLKLERPKTKSLKEILQNLQLSDKKTLIVLPWKEEGYMNVKLSGRNLPDVKVI IADNPNNSKNGEKAVRIDGLNVFDMLKYDYLVLTRDMVSKIEEVLGNEAGKALTA
Number of residues	None
Molecular Weight	26630.77
Theoretical pI	10.62
GO Classification	Functions structural constituent of ribosome rRNA binding Processes translation Components ribosome
General Function	Structural constituent of ribosome
Specific Function	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).This protein only weakly controls expression of the E.coli S10 operon. It is incorporated into E.coli ribosomes, however it is not as firmly associated as the endogenous protein.Forms part of the polypeptide exit tunnel.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P38516
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0012269\|50S ribosomal protein L4 (rplD) ATGGCTCAGGTTGATCTGTTGAATGTGAAGGGAGAAAAAGTAGGGACCCTGGAAATCAGT GATTTCGTTTTCAACATCGATCCCAACTACGACGTGATGTGGAGATACGTGGATATGCAG CTCTCCAACAGGAGAGCTGGAACTGCCTCTACGAAAACAAGAGGAGAAGTCTCCGGTGGT GGCAGAAAACCCTGGCCGCAGAAACACACTGGAAGAGCAAGACACGGATCCATAAGATCT CCCATCTGGAGACATGGAGGAGTAGTACACGGACCTAAACCGAGAGATTGGAGCAAAAAG CTCAACAAAAAAATGAAGAAACTCGCTTTGCGATCTGCCCTTTCTGTGAAGTACAGAGAA AACAAACTCCTTGTACTCGATGATCTGAAACTCGAAAGACCCAAGACAAAGTCTCTGAAG GAAATTCTCCAGAACCTTCAGCTTTCCGACAAGAAAACACTGATTGTCCTTCCGTGGAAA GAGGAAGGATATATGAATGTGAAACTCTCTGGAAGAAACCTTCCCGACGTGAAGGTAATA ATTGCGGACAATCCGAACAACAGCAAAAATGGTGAGAAGGCGGTAAGAATAGATGGACTC AATGTTTTTGACATGCTCAAGTACGATTACCTTGTTCTCACCAGGGACATGGTTTCCAAG ATAGAGGAGGTGCTCGGAAATGAAGCAGGAAAAGCTCTCACTGCATGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Sanangelantoni AM, Bocchetta M, Cammarano P, Tiboni O: Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima. J Bacteriol. 1994 Dec;176(24):7703-10. [8002596 ] Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [10360571 ] Worbs M, Wahl MC, Lindahl L, Zengel JM: Comparative anatomy of a regulatory ribosomal protein. Biochimie. 2002 Aug;84(8):731-43. [12457561 ] Worbs M, Huber R, Wahl MC: Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J. 2000 Mar 1;19(5):807-18. [10698923 ]

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