Hexon protein

Name	Hexon protein
Synonyms	CP-H Protein II
Gene Name	None
Organism	HAdV-2
Amino acid sequence	>lcl\|BSEQ0019391\|Hexon protein MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKFRNPTVAPTHDVTTDR SQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTA YNALAPKGAPNSCEWEQTEDSGRAVAEDEEEEDEDEEEEEEEQNARDQATKKTHVYAQAP LSGETITKSGLQIGSDNAETQAKPVYADPSYQPEPQIGESQWNEADANAAGGRVLKKTTP MKPCYGSYARPTNPFGGQSVLVPDEKGVPLPKVDLQFFSNTTSLNDRQGNATKPKVVLYS EDVNMETPDTHLSYKPGKGDENSKAMLGQQSMPNRPNYIAFRDNFIGLMYYNSTGNMGVL AGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVRIIENHGTED ELPNYCFPLGGIGVTDTYQAIKANGNGSGDNGDTTWTKDETFATRNEIGVGNNFAMEINL NANLWRNFLYSNIALYLPDKLKYNPTNVEISDNPNTYDYMNKRVVAPGLVDCYINLGARW SLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWN FRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLRNDTNDQSFN DYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSGYDPYYTYSGS IPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKD WFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYKEYQQVGILHQHN NSGFVGYLAPTMREGQAYPANVPYPLIGKTAVDSITQKKFLCDRTLWRIPFSSNFMSMGA LTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQPHRGVIETVYLRTP FSAGNATT
Number of residues	None
Molecular Weight	109151.995
Theoretical pI	4.84
GO Classification	Functions structural molecule activity Processes viral entry into host cell microtubule-dependent intracellular transport of viral material towards nucleus Components host cell nucleus T=25 icosahedral viral capsid
General Function	Structural molecule activity
Specific Function	Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P03277
UniProtKB Entry Name
Cellular Location	Virion
Gene sequence	>lcl\|BSEQ0006352\|2907 bp ATGGCTACCCCTTCGATGATGCCGCAGTGGTCTTACATGCACATCTCGGGCCAGGACGCC TCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTTGCCCGCGCCACCGAGACGTACTTCAGC CTGAATAACAAGTTTAGAAACCCCACGGTGGCACCTACGCACGACGTAACCACAGACCGG TCCCAGCGTTTGACGCTGCGGTTCATCCCTGTGGACCGCGAGGATACCGCGTACTCGTAC AAAGCGCGGTTCACCCTGGCTGTGGGTGACAACCGTGTGCTTGATATGGCTTCCACGTAC TTTGACATCCGCGGCGTGCTGGACAGGGGGCCTACTTTTAAGCCCTACTCCGGCACTGCC TACAACGCTCTAGCTCCCAAGGGCGCTCCTAACTCCTGTGAGTGGGAACAAACCGAAGAT AGCGGCCGGGCAGTTGCCGAGGATGAAGAAGAGGAAGATGAAGATGAAGAAGAGGAAGAA GAAGAGCAAAACGCTCGAGATCAGGCTACTAAGAAAACACATGTCTATGCCCAGGCTCCT TTGTCTGGAGAAACAATTACAAAAAGCGGGCTACAAATAGGATCAGACAATGCAGAAACA CAAGCTAAACCTGTATACGCAGATCCTTCCTATCAACCAGAACCTCAAATTGGCGAATCT CAGTGGAACGAAGCTGATGCTAATGCGGCAGGAGGGAGAGTGCTTAAAAAAACAACTCCC ATGAAACCATGCTATGGATCTTATGCCAGGCCTACAAATCCTTTTGGTGGTCAATCCGTT CTGGTTCCGGATGAAAAAGGGGTGCCTCTTCCAAAGGTTGACTTGCAATTCTTCTCAAAT ACTACCTCTTTGAACGACCGGCAAGGCAATGCTACTAAACCAAAAGTGGTTTTGTACAGT GAAGATGTAAATATGGAAACCCCAGACACACATCTGTCTTACAAACCTGGAAAAGGTGAT GAAAATTCTAAAGCTATGTTGGGTCAACAATCTATGCCAAACAGACCCAATTACATTGCT TTCAGGGACAATTTTATTGGCCTAATGTATTATAACAGCACTGGCAACATGGGTGTTCTT GCTGGTCAGGCATCGCAGCTAAATGCCGTGGTAGATTTGCAAGACAGAAACACAGAGCTG TCCTATCAACTCTTGCTTGATTCCATAGGTGATAGAACCAGATATTTTTCTATGTGGAAT CAGGCTGTAGACAGCTATGATCCAGATGTTAGAATCATTGAAAACCATGGAACTGAGGAT GAATTGCCAAATTATTGTTTTCCTCTTGGGGGTATTGGGGTAACTGACACCTATCAAGCT ATTAAGGCTAATGGCAATGGCTCAGGCGATAATGGAGATACTACATGGACAAAAGATGAA ACTTTTGCAACACGTAATGAAATAGGAGTGGGTAACAACTTTGCCATGGAAATTAACCTA AATGCCAACCTATGGAGAAATTTCCTTTACTCCAATATTGCGCTGTACCTGCCAGACAAG CTAAAATACAACCCCACCAATGTGGAAATATCTGACAACCCCAACACCTACGACTACATG AACAAGCGAGTGGTGGCTCCCGGGCTTGTAGACTGCTACATTAACCTTGGGGCGCGCTGG TCTCTGGACTACATGGACAACGTTAATCCCTTTAACCACCACCGCAATGCGGGCCTCCGT TATCGCTCCATGTTGTTGGGAAACGGCCGCTACGTGCCCTTTCACATTCAGGTGCCCCAA AAGTTTTTTGCCATTAAAAACCTCCTCCTCCTGCCAGGCTCATATACATATGAATGGAAC TTCAGGAAGGATGTTAACATGGTTCTGCAGAGCTCTCTGGGAAACGATCTTAGAGTTGAC GGGGCTAGCATTAAGTTTGACAGCATTTGTCTTTACGCCACCTTCTTCCCCATGGCCCAC AACACGGCCTCCACGCTGGAAGCCATGCTCAGAAATGACACCAACGACCAGTCCTTTAAT GACTACCTTTCCGCCGCCAACATGCTATACCCCATACCCGCCAACGCCACCAACGTGCCC ATCTCCATCCCATCGCGCAACTGGGCAGCATTTCGCGGTTGGGCCTTCACACGCTTGAAG ACAAAGGAAACCCCTTCCCTGGGATCAGGCTACGACCCTTACTACACCTACTCTGGCTCC ATACCATACCTTGACGGAACCTTCTATCTTAATCACACCTTTAAGAAGGTGGCCATTACC TTTGACTCTTCTGTTAGCTGGCCGGGCAACGACCGCCTGCTTACTCCCAATGAGTTTGAG ATTAAACGCTCAGTTGACGGGGAGGGCTACAACGTAGCTCAGTGCAACATGACCAAGGAC TGGTTCCTGGTGCAGATGTTGGCCAACTACAATATTGGCTACCAGGGCTTCTACATTCCA GAAAGCTACAAGGACCGCATGTACTCGTTCTTCAGAAACTTCCAGCCCATGAGCCGGCAA GTGGTTGACGATACTAAATACAAGGAGTATCAGCAGGTTGGAATTCTTCACCAGCATAAC AACTCAGGATTCGTAGGCTACCTCGCTCCCACCATGCGCGAGGGACAGGCTTACCCCGCC AACGTGCCCTACCCACTAATAGGCAAAACCGCGGTTGACAGTATTACCCAGAAAAAGTTT CTTTGCGATCGCACCCTTTGGCGCATCCCATTCTCCAGTAACTTTATGTCCATGGGCGCA CTCACAGACCTGGGCCAAAACCTTCTCTACGCCAACTCCGCCCACGCGCTAGACATGACT TTTGAGGTGGATCCCATGGACGAGCCCACCCTTCTTTATGTTTTGTTTGAAGTCTTTGAC GTGGTCCGTGTGCACCAGCCGCACCGCGGCGTCATCGAGACCGTGTACCTGCGCACGCCC TTCTCGGCCGGCAACGCCACAACATAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Akusjarvi G, Alestrom P, Pettersson M, Lager M, Jornvall H, Pettersson U: The gene for the adenovirus 2 hexon polypeptide. J Biol Chem. 1984 Nov 25;259(22):13976-9. [6501284 ] Jornvall H, Akusjarvi G, Alestrom P, von Bahr-Lindstrom H, Pettersson U, Appella E, Fowler AV, Philipson L: The adenovirus hexon protein. The primary structure of the polypeptide and its correlation with the hexon gene. J Biol Chem. 1981 Jun 25;256(12):6181-6. [6263909 ] Bergstrom Lind S, Artemenko KA, Elfineh L, Zhao Y, Bergquist J, Pettersson U: The phosphoproteome of the adenovirus type 2 virion. Virology. 2012 Nov 10;433(1):253-61. doi: 10.1016/j.virol.2012.08.012. Epub 2012 Aug 28. [22939182 ] Akusjarvi G, Zabielski J, Perricaudet M, Pettersson U: The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene. Nucleic Acids Res. 1981 Jan 10;9(1):1-17. [6259616 ] Cepko CL, Sharp PA: Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 1982 Dec;31(2 Pt 1):407-15. [7159928 ] Jornvall H, Ohlsson H, Philipson L: An acetylated N-terminus of adenovirus type 2 hexon protein. Biochem Biophys Res Commun. 1974 Jan 23;56(2):304-10. [4823869 ] Matthews DA, Russell WC: Adenovirus protein-protein interactions: molecular parameters governing the binding of protein VI to hexon and the activation of the adenovirus 23K protease. J Gen Virol. 1995 Aug;76 ( Pt 8):1959-69. [7636476 ] Wodrich H, Guan T, Cingolani G, Von Seggern D, Nemerow G, Gerace L: Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 2003 Dec 1;22(23):6245-55. [14633984 ] Hong SS, Szolajska E, Schoehn G, Franqueville L, Myhre S, Lindholm L, Ruigrok RW, Boulanger P, Chroboczek J: The 100K-chaperone protein from adenovirus serotype 2 (Subgroup C) assists in trimerization and nuclear localization of hexons from subgroups C and B adenoviruses. J Mol Biol. 2005 Sep 9;352(1):125-38. [16081097 ] Bremner KH, Scherer J, Yi J, Vershinin M, Gross SP, Vallee RB: Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe. 2009 Dec 17;6(6):523-35. doi: 10.1016/j.chom.2009.11.006. [20006841 ] San Martin C: Latest insights on adenovirus structure and assembly. Viruses. 2012 May;4(5):847-77. doi: 10.3390/v4050847. Epub 2012 May 21. [22754652 ] Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH: Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science. 2010 Aug 27;329(5995):1038-43. doi: 10.1126/science.1187433. [20798312 ] Athappilly FK, Murali R, Rux JJ, Cai Z, Burnett RM: The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution. J Mol Biol. 1994 Sep 30;242(4):430-55. [7932702 ]

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