Cell division protein FtsZ

Name	Cell division protein FtsZ
Synonyms
Gene Name	ftsZ
Organism	Mycobacterium tuberculosis
Amino acid sequence	>lcl\|BSEQ0051239\|Cell division protein FtsZ MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMSDADVKLDVGR DSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGEGGGTGTGGAPVVASIARK LGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIVIPNDRLLQMGDAAVSLMDAF RSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALMGIGSARGEGRSLKAAEI AINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAASLVQDAAHPDANIIFGTVIDDSLG DEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIESAKAGKLTSTLFEPVDAVSVPLHTNGA TLSIGGDDDDVDVPPFMRR
Number of residues	None
Molecular Weight	38755.52
Theoretical pI	None
GO Classification	Functions GTP binding GTPase activity magnesium ion binding Processes protein polymerization growth cell cycle barrier septum assembly Components cytoplasm plasma membrane cell division site
General Function	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Specific Function	Gtp binding
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P9WN95
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0051240\|Cell division protein FtsZ (ftsZ) ATGACCCCCCCGCACAACTACCTGGCCGTCATCAAGGTCGTGGGTATCGGTGGTGGCGGT GTCAACGCCGTCAACCGAATGATCGAGCAGGGCCTCAAAGGCGTGGAATTCATCGCGATC AACACCGACGCCCAGGCGTTGTTGATGAGCGATGCCGACGTCAAACTCGACGTCGGCCGC GACTCCACCCGCGGGCTGGGCGCCGGCGCCGATCCGGAGGTCGGCCGTAAGGCCGCCGAG GACGCCAAGGACGAGATCGAAGAGCTGCTGCGCGGTGCCGACATGGTGTTTGTCACCGCC GGCGAGGGGGGCGGAACCGGCACCGGGGGGGCACCCGTCGTCGCCAGCATCGCCCGCAAG CTGGGCGCGTTGACCGTCGGTGTGGTCACCCGGCCGTTCTCGTTCGAGGGCAAGCGACGC AGCAATCAGGCCGAAAATGGCATCGCGGCGCTGCGGGAGAGTTGCGACACCCTCATCGTG ATTCCCAACGACCGGTTGCTGCAGATGGGAGATGCCGCGGTATCGCTGATGGATGCTTTC CGTAGCGCCGACGAGGTGCTGCTCAACGGCGTGCAGGGCATCACCGACCTGATTACCACC CCGGGTCTAATCAACGTCGACTTCGCCGACGTCAAGGGCATCATGTCCGGTGCCGGCACC GCACTGATGGGCATCGGCTCGGCCCGGGGCGAAGGCCGGTCGCTCAAAGCGGCCGAGATC GCCATCAACTCGCCGTTGCTGGAAGCCTCGATGGAGGGCGCGCAAGGCGTGCTGATGTCG ATCGCCGGCGGCAGCGACTTGGGCTTGTTCGAGATCAACGAGGCGGCCTCGTTGGTACAA GACGCCGCTCACCCCGATGCCAACATCATCTTCGGCACCGTCATCGACGATTCGCTCGGT GACGAGGTGCGGGTGACCGTGATCGCGGCCGGCTTCGACGTCAGCGGTCCCGGCCGCAAG CCGGTGATGGGCGAGACCGGCGGCGCCCACCGGATCGAGTCAGCCAAGGCAGGCAAGCTC ACCTCGACCTTGTTCGAGCCGGTCGACGCCGTCAGCGTGCCGTTGCACACCAACGGCGCA ACCCTGAGCATCGGCGGTGATGACGACGATGTCGACGTGCCGCCCTTCATGCGCCGCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [9634230 ] Sureka K, Hossain T, Mukherjee P, Chatterjee P, Datta P, Kundu M, Basu J: Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division. PLoS One. 2010 Jan 6;5(1):e8590. doi: 10.1371/journal.pone.0008590. [20066037 ] Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [21969609 ] Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW: Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J Mol Biol. 2004 Sep 17;342(3):953-70. [15342249 ] Respicio L, Nair PA, Huang Q, Anil B, Tracz S, Truglio JJ, Kisker C, Raleigh DP, Ojima I, Knudson DL, Tonge PJ, Slayden RA: Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinb). 2008 Sep;88(5):420-9. doi: 10.1016/j.tube.2008.03.001. Epub 2008 May 13. [18479968 ] Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S: FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation. Science. 2013 Jul 26;341(6144):392-5. doi: 10.1126/science.1239248. [23888039 ]

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