Pyruvate decarboxylase

Name	Pyruvate decarboxylase
Synonyms	4.1.1.1 PDC
Gene Name	pdc
Organism	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Amino acid sequence	>lcl\|BSEQ0017043\|Pyruvate decarboxylase MSYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGY ARAKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTD YHYQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPGP ASALFNDEASDEASLNAAVEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAV ATMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPD PKKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKKTGALDFFKSLNAGELKKAAPAD PSAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLPNGARVEYEMQWGHIGWSVP AAFGYAVGAPERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLINNYGYTIEVMIHDGP YNNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAEAIKVALANTDGPTLIECFIG REDCTEELVKWGKRVAAANSRKPVNKLL
Number of residues	None
Molecular Weight	60925.005
Theoretical pI	5.96
GO Classification	Functions magnesium ion binding thiamine pyrophosphate binding pyruvate decarboxylase activity Processes Components
General Function	Thiamine pyrophosphate binding
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P06672
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0017044\|Pyruvate decarboxylase (pdc) ATGAGTTATACTGTCGGTACCTATTTAGCGGAGCGGCTTGTCCAGATTGGTCTCAAGCAT CACTTCGCAGTCGCGGGCGACTACAACCTCGTCCTTCTTGACAACCTGCTTTTGAACAAA AACATGGAGCAGGTTTATTGCTGTAACGAACTGAACTGCGGTTTCAGTGCAGAAGGTTAT GCTCGTGCCAAAGGCGCAGCAGCAGCCGTCGTTACCTACAGCGTCGGTGCGCTTTCCGCA TTTGATGCTATCGGTGGCGCCTATGCAGAAAACCTTCCGGTTATCCTGATCTCCGGTGCT CCGAACAACAATGATCACGCTGCTGGTCACGTGTTGCATCACGCTCTTGGCAAAACCGAC TATCACTATCAGTTGGAAATGGCCAAGAACATCACGGCCGCCGCTGAAGCGATTTACACC CCGGAAGAAGCTCCGGCTAAAATCGATCACGTGATTAAAACTGCTCTTCGTGAGAAGAAG CCGGTTTATCTCGAAATCGCTTGCAACATTGCTTCCATGCCCTGCGCCGCTCCTGGACCG GCAAGCGCATTGTTCAATGACGAAGCCAGCGACGAAGCTTCTTTGAATGCAGCGGTTGAA GAAACCCTGAAATTCATCGCCAACCGCGACAAAGTTGCCGTCCTCGTCGGCAGCAAGCTG CGCGCAGCTGGTGCTGAAGAAGCTGCTGTCAAATTTGCTGATGCTCTCGGTGGCGCAGTT GCTACCATGGCTGCTGCAAAAAGCTTCTTCCCAGAAGAAAACCCGCATTACATCGGCACC TCATGGGGTGAAGTCAGCTATCCGGGCGTTGAAAAGACGATGAAAGAAGCCGATGCGGTT ATCGCTCTGGCTCCTGTCTTCAACGACTACTCCACCACTGGTTGGACGGATATTCCTGAT CCTAAGAAACTGGTTCTCGCTGAACCGCGTTCTGTCGTCGTTAACGGCATTCGCTTCCCC AGCGTCCATCTGAAAGACTATCTGACCCGTTTGGCTCAGAAAGTTTCCAAGAAAACCGGT GCATTGGACTTCTTCAAATCCCTCAATGCAGGTGAACTGAAGAAAGCCGCTCCGGCTGAT CCGAGTGCTCCGTTGGTCAACGCAGAAATCGCCCGTCAGGTCGAAGCTCTTCTGACCCCG AACACGACGGTTATTGCTGAAACCGGTGACTCTTGGTTCAATGCTCAGCGCATGAAGCTC CCGAACGGTGCTCGCGTTGAATATGAAATGCAGTGGGGTCACATTGGTTGGTCCGTTCCT GCCGCCTTCGGTTATGCCGTCGGTGCTCCGGAACGTCGCAACATCCTCATGGTTGGTGAT GGTTCCTTCCAGCTGACGGCTCAGGAAGTCGCTCAGATGGTTCGCCTGAAACTGCCGGTT ATCATCTTCTTGATCAATAACTATGGTTACACCATCGAAGTTATGATCCATGATGGTCCG TACAACAACATCAAGAACTGGGATTATGCCGGTCTGATGGAAGTGTTCAACGGTAACGGT GGTTATGACAGCGGTGCTGGTAAAGGCCTGAAGGCTAAAACCGGTGGCGAACTGGCAGAA GCTATCAAGGTTGCTCTGGCAAACACCGACGGCCCAACCCTGATCGAATGCTTCATCGGT CGTGAAGACTGCACTGAAGAATTGGTCAAATGGGGTAAGCGCGTTGCTGCCGCCAACAGC CGTAAGCCTGTTAACAAGCTCCTCTAG
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Neale AD, Scopes RK, Wettenhall RE, Hoogenraad NJ: Pyruvate decarboxylase of Zymomonas mobilis: isolation, properties, and genetic expression in Escherichia coli. J Bacteriol. 1987 Mar;169(3):1024-8. [3546263 ] Neale AD, Scopes RK, Wettenhall RE, Hoogenraad NJ: Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis. Nucleic Acids Res. 1987 Feb 25;15(4):1753-61. [3029726 ] Conway T, Osman YA, Konnan JI, Hoffmann EM, Ingram LO: Promoter and nucleotide sequences of the Zymomonas mobilis pyruvate decarboxylase. J Bacteriol. 1987 Mar;169(3):949-54. [3029037 ] Reynen M, Sahm H: Comparison of the structural genes for pyruvate decarboxylase in different Zymomonas mobilis strains. J Bacteriol. 1988 Jul;170(7):3310-3. [2838467 ] Seo JS, Chong H, Park HS, Yoon KO, Jung C, Kim JJ, Hong JH, Kim H, Kim JH, Kil JI, Park CJ, Oh HM, Lee JS, Jin SJ, Um HW, Lee HJ, Oh SJ, Kim JY, Kang HL, Lee SY, Lee KJ, Kang HS: The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4. Nat Biotechnol. 2005 Jan;23(1):63-8. Epub 2004 Dec 12. [15592456 ] Candy JM, Koga J, Nixon PF, Duggleby RG: The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase. Biochem J. 1996 May 1;315 ( Pt 3):745-51. [8645153 ] Candy JM, Duggleby RG: Structure and properties of pyruvate decarboxylase and site-directed mutagenesis of the Zymomonas mobilis enzyme. Biochim Biophys Acta. 1998 Jun 29;1385(2):323-38. [9655927 ] Dobritzsch D, Konig S, Schneider G, Lu G: High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis. Implications for substrate activation in pyruvate decarboxylases. J Biol Chem. 1998 Aug 7;273(32):20196-204. [9685367 ]

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