Isocitrate dehydrogenase [NADP]


NameIsocitrate dehydrogenase [NADP]
Synonyms
  • 1.1.1.42
  • citC
  • IDH
  • IDP
  • NADP(+)-specific ICDH
  • Oxalosuccinate decarboxylase
Gene Nameicd
OrganismBacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0011078|Isocitrate dehydrogenase [NADP]
MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKE
VYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLR
PVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIR
FPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA
EKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEF
DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPS
SVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGEELIK
NMD
Number of residuesNone
Molecular Weight46417.39
Theoretical pI4.74
GO Classification
Functions
  • NAD binding
  • isocitrate dehydrogenase (NADP+) activity
  • magnesium ion binding
Processes
  • tricarboxylic acid cycle
  • glyoxylate cycle
Components
General FunctionNad binding
Specific FunctionNone
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP39126
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0011079|Isocitrate dehydrogenase [NADP] (icd)
GTGGCACAAGGTGAAAAAATTACAGTCTCTAACGGAGTATTAAACGTACCAAACAACCCG
ATTATCCCATTTATCGAAGGAGACGGAACCGGTCCTGATATTTGGAACGCGGCTTCGAAG
GTTTTGGAAGCAGCAGTAGAAAAAGCATACAAAGGCGAAAAGAAAATTACATGGAAAGAA
GTTTACGCCGGAGAAAAGGCTTATAATAAAACAGGTGAGTGGCTCCCTGCTGAAACATTA
GATGTGATCCGCGAATATTTCATCGCGATTAAAGGCCCGTTAACGACACCTGTCGGCGGC
GGTATCCGTTCTTTGAACGTAGCGCTCAGACAAGAGCTTGACCTATTCGTCTGCTTAAGA
CCTGTAAGATACTTTACTGGAGTGCCGTCACCGGTAAAACGCCCTGAAGATACTGATATG
GTCATCTTCCGTGAAAATACAGAAGATATTTACGCAGGCATCGAGTATGCAAAAGGCTCT
GAAGAAGTGCAAAAGCTTATCAGCTTCCTTCAAAATGAGTTAAACGTCAATAAAATCCGT
TTCCCTGAGACATCAGGTATCGGCATTAAGCCTGTTTCAGAAGAAGGAACAAGCCGCTTG
GTCAGAGCTGCCATTGATTATGCGATCGAGCATGGCCGCAAATCTGTAACACTTGTTCAC
AAAGGAAACATCATGAAGTTCACAGAAGGCGCCTTCAAAAACTGGGGCTATGAACTTGCT
GAAAAAGAATACGGAGATAAAGTCTTCACATGGGCTCAATATGACCGCATTGCTGAAGAA
CAAGGAAAAGACGCTGCCAACAAAGCGCAAAGCGAAGCGGAAGCAGCAGGAAAAATCATT
ATCAAAGACAGCATTGCTGACATTTTCCTTCAGCAGATCTTAACGCGTCCAAACGAGTTT
GATGTCGTTGCGACAATGAACTTGAACGGAGATTACATTTCTGATGCTCTTGCTGCGCAA
GTCGGCGGAATCGGCATTGCTCCTGGAGCGAACATCAACTACGAAACAGGACATGCGATT
TTCGAGGCGACGCACGGAACGGCTCCTAAATATGCAGGCCTTGATAAAGTAAACCCATCT
TCAGTTATTCTTTCAGGCGTTCTGCTTCTTGAGCATTTAGGATGGAACGAAGCGGCTGAT
TTGGTTATCAAATCTATGGAAAAAACAATCGCTTCTAAAGTCGTAACTTACGATTTTGCC
AGATTAATGGACGGGGCGACTGAAGTGAAATGTTCAGAGTTCGGAGAAGAACTGATCAAA
AACATGGACTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Jin S, Sonenshein AL: Identification of two distinct Bacillus subtilis citrate synthase genes. J Bacteriol. 1994 Aug;176(15):4669-79. [8045898 ]
  2. Lapidus A, Galleron N, Sorokin A, Ehrlich SD: Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology. 1997 Nov;143 ( Pt 11):3431-41. [9387221 ]
  3. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [9384377 ]
  4. Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC: Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J Biol Chem. 2002 Mar 1;277(9):7567-73. Epub 2002 Jan 7. [11751849 ]
  5. Singh SK, Matsuno K, LaPorte DC, Banaszak LJ: Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J Biol Chem. 2001 Jul 13;276(28):26154-63. Epub 2001 Apr 4. [11290745 ]

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