Aromatic-amino-acid aminotransferase

Name	Aromatic-amino-acid aminotransferase
Synonyms	2.6.1.57 ARAT
Gene Name	tyrB
Organism	Paracoccus denitrificans
Amino acid sequence	>lcl\|BSEQ0010973\|Aromatic-amino-acid aminotransferase MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETE TTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRV FVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHN PTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAAS CSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPEL RADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKE EFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV
Number of residues	None
Molecular Weight	42731.635
Theoretical pI	5.49
GO Classification	Functions pyridoxal phosphate binding L-phenylalanine aromatic-amino-acid Processes aromatic amino acid family biosynthetic process Components cytoplasm
General Function	Pyridoxal phosphate binding
Specific Function	Shows activities toward both dicarboxylic and aromatic substrates.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P95468
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0002756\|1185 bp ATGCTGGGCAATCTGAAACCGCAGGCCCCCGACAAGATCCTGGCCCTGATGGGCGAATTC AGGGCCGATCCCCGCCAGGGCAAGATCGACCTGGGCGTGGGGGTCTACAAGGATGCCACC GGCCACACCCCGATCATGCGGGCCGTCCACGCCGCCGAGCAGCGCATGCTGGAAACCGAG ACCACCAAGACCTATGCCGGCCTCTCGGGCGAGCCCGAGTTCCAAAAGGCCATGGGCGAG CTGATCCTGGGCGACGGACTGAAATCCGAGACCACCGCGACGCTGGCGACGGTCGGCGGC ACCGGCGCCCTCCGGCAGGCGCTGGAACTGGCGCGCATGGCGAACCCGGACCTGCGGGTC TTCGTCAGCGATCCGACCTGGCCGAACCATGTCTCGATCATGAATTTCATGGGCCTGCCG GTGCAGACCTATCGCTATTTCGATGCCGAGACCCGCGGCGTCGATTTCGAGGGCATGAAG GCCGACCTCGCCGCCGCGAAAAAGGGCGACATGGTGCTGCTGCACGGCTGCTGCCACAAC CCGACCGGCGCCAACCTGACGCTGGATCAATGGGCCGAGATCGCCTCGATCCTGGAAAAG ACCGGCGCGCTGCCGCTGATCGACCTGGCCTATCAGGGCTTCGGCGACGGGCTGGAAGAG GACGCGGCCGGCACCCGGCTGATCGCCTCGCGCATCCCCGAGGTGCTGATCGCGGCCTCG TGCAGCAAGAACTTCGGCATCTACCGCGAACGCACCGGCTGCCTGCTGGCGCTTTGCGCC GATGCGGCGACCAGGGAGCTGGCGCAGGGCGCCATGGCCTTCCTGAACCGCCAGACCTAT TCCTTCCCGCCCTTCCACGGCGCCAAGATCGTCTCGACCGTGCTGACCACGCCCGAACTG CGCGCCGACTGGATGGCCGAGCTGGAAGCGGTGCGCAGCGGCATGCTGCGCCTGCGCGAG CAATTGGCGGGCGAGTTGCGCGATCTCAGCGGTTCGGACCGTTTCGGCTTCGTGGCCGAG CATCGCGGCATGTTCTCGCGCCTGGGCGCCACGCCCGAACAGGTCAAGCGCATCAAGGAA GAGTTCGGCATCTACATGGTGGGCGATTCGCGCATCAACATCGCCGGGCTGAACGACAAC ACCATCCCGATCCTGGCCCGCGCTATCATCGAGGTGGGGGTCTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Oue S, Okamoto A, Nakai Y, Nakahira M, Shibatani T, Hayashi H, Kagamiyama H: Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism. J Biochem. 1997 Jan;121(1):161-71. [9058208 ] Okamoto A, Nakai Y, Hayashi H, Hirotsu K, Kagamiyama H: Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network. J Mol Biol. 1998 Jul 17;280(3):443-61. [9665848 ] Okamoto A, Ishii S, Hirotsu K, Kagamiyama H: The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity. Biochemistry. 1999 Jan 26;38(4):1176-84. [9930977 ]

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