Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Name	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Synonyms	2.4.2.21 N(1)-alpha-phosphoribosyltransferase NN:DBI PRT
Gene Name	cobT
Organism	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence	>lcl\|BSEQ0002447\|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGE KAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAE PIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANT TPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGG FDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIAL AHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
Number of residues	None
Molecular Weight	36612.305
Theoretical pI	6.3
GO Classification	Functions nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity cobalamin-transporting ATPase activity Processes cobalamin biosynthetic process nucleoside biosynthetic process Components
General Function	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Specific Function	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q05603
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0016358\|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT) ATGCAGACACTACACGCTTTACTCCGTGACATTCCTGCGCCGGACGCCGAGGCGATGGCG CGTGCGCAGCAACATATTGACGGCCTGCTCAAACCGCCGGGCAGCCTGGGCAGACTGGAA ACCTTAGCCGTTCAGCTCGCGGGTATGCCGGGTCTTAACGGTACGCCGCAGGTAGGTGAA AAGGCGGTGCTGGTGATGTGCGCCGACCATGGCGTCTGGGATGAAGGCGTAGCGGTTTCG CCCAAAATCGTGACGGCGATTCAGGCGGCGAATATGACGCGGGGAACAACCGGCGTATGC GTGCTTGCCGCTCAGGCCGGTGCGAAGGTGCATGTCATTGATGTCGGTATTGATGCCGAA CCTATTCCTGGCGTAGTTAATATGCGCGTCGCGCGCGGCTGCGGAAATATTGCCGTTGGC CCGGCGATGAGTCGCTTGCAGGCTGAGGCGCTTTTGCTGGAGGTTTCCCGCTACACCTGC GACCTGGCGCAACGCGGCGTGACCTTATTTGGCGTAGGGGAGCTGGGAATGGCGAACACT ACGCCAGCCGCCGCGATGGTCAGCGTTTTTACAGGAAGTGATGCAAAAGAGGTGGTGGGG ATTGGCGCGAATCTTCCGCCTTCCCGCATCGATAATAAAGTGGACGTCGTGCGGCGGGCG ATTGCGATTAATCAGCCCAATCCGCGCGACGGCATTGATGTGTTGTCGAAGGTGGGTGGT TTTGATCTGGTCGGGATGACCGGCGTGATGCTTGGCGCGGCAAGGTGTGGCTTACCCGTA TTGCTGGATGGCTTTCTTTCCTACTCGGCAGCGCTGGCGGCCTGTCAGATTGCGCCTGCG GTGAGACCTTATCTGATCCCGTCGCACTTTTCGGCGGAAAAGGGCGCCCGCATCGCGCTC GCGCATTTGTCTATGGAACCCTATTTGCATATGGCGATGCGGTTAGGTGAAGGAAGCGGC GCGGCGCTGGCGATGCCGATCGTGGAAGCCGCGTGCGCCATGTTCCACAACATGGGGGAG TTGGCGGCCAGTAATATTGTCCTGCCGGAGGGGAACGCAAACGCAACATAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Chen P, Ailion M, Weyand N, Roth J: The end of the cob operon: evidence that the last gene (cobT) catalyzes synthesis of the lower ligand of vitamin B12, dimethylbenzimidazole. J Bacteriol. 1995 Mar;177(6):1461-9. [7883701 ] McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [11677609 ] Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM: Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J Bacteriol. 1993 Jun;175(11):3303-16. [8501034 ] Cheong CG, Escalante-Semerena JC, Rayment I: The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution. Biochemistry. 1999 Dec 7;38(49):16125-35. [10587435 ]

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