Inosine-5'-monophosphate dehydrogenase

Name	Inosine-5'-monophosphate dehydrogenase
Synonyms	1.1.1.205 IMP dehydrogenase impD
Gene Name	guaB
Organism	Streptococcus pyogenes
Amino acid sequence	>lcl\|BSEQ0016659\|Inosine-5'-monophosphate dehydrogenase MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSK MAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRY RISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERIL HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG NAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP EGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHD VQITNEAPNYSVH
Number of residues	None
Molecular Weight	52806.77
Theoretical pI	5.88
GO Classification	Functions IMP dehydrogenase activity metal ion binding Processes GMP biosynthetic process Components
General Function	Metal ion binding
Specific Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P0C0H6
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0004042\|1482 bp ATGTCAAATTGGGACACTAAATTTTTAAAAAAAGGCTACACTTTTGACGATGTCTTGCTT ATTCCGGCAGAGAGTCATGTTCTTCCAAATGAAGTTGATTTAAAGACAAAACTCGCAGAC AATTTGACATTAAATATTCCTATTATTACAGCAGCTATGGATACGGTTACTGGTAGTAAA ATGGCTATTGCAATTGCGCGTGCGGGTGGTTTAGGTGTTATTCATAAAAACATGTCTATT ACTGAGCAAGCAGAAGAAGTTCGCAAGGTAAAACGTTCTGAAAATGGTGTCATCATTGAT CCATTCTTCTTAACACCTGAACACAAGGTTTCAGAAGCTGAAGAATTAATGCAGCGCTAC CGTATCAGTGGTGTGCCAATTGTTGAAACTTTAGCAAACCGTAAGTTGGTCGGTATCATT ACTAATCGTGATATGCGTTTTATTTCTGATTACAATGCACCAATCTCTGAACATATGACT AGTGAGCACCTCGTTACGGCTGCTGTTGGTACAGATCTTGAAACTGCAGAACGTATTCTT CATGAACACCGTATTGAAAAACTTCCTTTGGTTGATAATAGCGGTCGTCTATCTGGTTTA ATCACTATCAAAGATATTGAAAAAGTAATCGAATTCCCACATGCTGCTAAAGATGAATTT GGTCGTCTTCTGGTCGCTGCTGCGGTAGGTGTTACCTCAGATACTTTTGAGCGTGCCGAG GCCTTGTTTGAAGCTGGTGCAGATGCGATTGTTATTGACACAGCTCATGGTCATTCGGCT GGTGTTCTTCGTAAAATTGCTGAGATTCGTGCTCATTTCCCAAATCGTACTTTGATTGCT GGAAATATTGCCACTGCTGAAGGTGCGCGTGCTCTTTATGATGCAGGTGTTGATGTTGTT AAAGTGGGTATTGGTCCCGGATCTATCTGTACCACTCGTGTGGTTGCAGGTGTCGGTGTT CCTCAAGTGACTGCTATTTACGATGCTGCTGCTGTTGCTCGTGAATATGGCAAAACGATT ATTGCTGATGGTGGTATCAAGTATTCTGGCGATATTGTTAAGGCTCTTGCAGCCGGTGGT AATGCTGTTATGCTTGGATCAATGTTTGCAGGTACTGATGAAGCTCCAGGTGAAACTGAA ATCTACCAAGGCCGTAAGTTCAAAACTTATCGTGGAATGGGTTCCATTGCAGCTATGAAG AAAGGATCAAGCGATCGTTACTTCCAAGGTTCCGTCAATGAAGCTAATAAACTAGTTCCA GAAGGTATTGAAGGCCGTGTTGCTTATAAAGGAGCTGCTTCAGATATTGTCTTCCAAATG TTAGGTGGTATCCGCTCAGGTATGGGCTATGTTGGCGCAGGTGACATTCAAGAATTACAT GAAAATGCTCAATTTGTTGAAATGTCAGGTGCAGGCTTGATTGAAAGTCATCCACATGAT GTTCAAATCACAAATGAAGCACCAAACTATTCTGTGCACTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Ashbaugh CD, Wessels MR: Cloning, sequence analysis and expression of the group A streptococcal guaB gene encoding inosine monophosphate dehydrogenase. Gene. 1995 Nov 7;165(1):57-60. [7489916 ] Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR: Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. Biochemistry. 1999 Apr 13;38(15):4691-700. [10200156 ]

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