O-GlcNAcase NagJ

Name	O-GlcNAcase NagJ
Synonyms	3.2.1.169 Beta-hexosaminidase Beta-N-acetylglucosaminidase Beta-N-acetylhexosaminidase Hexosaminidase B N-acetyl-beta-D-glucosaminidase N-acetyl-beta-glucosaminidase
Gene Name	nagJ
Organism	Clostridium perfringens (strain 13 / Type A)
Amino acid sequence	>lcl\|BSEQ0017074\|O-GlcNAcase NagJ MKRKMLKRLLTSAFACMFIANGLITTTVRAVGPKTGEENQVLVPNLNPTPENLEVVGDGF KITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGEVDDDIPELDEAL NGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTFKQLVKESNIPEVNITDYPTVS ARGIVEGFYGTPWTHKDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPENEMQRMQ ELIDASAENKVDFVFGISPGIDIRFDGEAGEEDFNHLIAKAESLYDMGVRSFAIYWDDIQ DKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRTYTRIFAETVDPS IEVMWTGPGVVTNEIPLSDAQLISGIYNRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLN QYVDFFTVNPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFAN HSTRMDNKTWAKSGREDAPELRAKMDELWNKLSSKEDASALIEELYGEFARMEEACNNLK ANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKEIAQNKLNTALSS FAVISEKVAQSFIQEALSFDLTLINPRTVKITASSEETSGENAPASFASDGDMNTFWHSK WSSPAHEGPHHLTLELDNVYEINKVKYAPRQDSKNGRITGYKVSVSLDGENFTEVKTGTL EDNAAIKFIEFDSVDAKYVRLDVTDSVSDQANGRGKFATAAEVNVHGKLKEAAEVTGSVS LEALEEVQVGENIEVGVGIDELVNAEAFAYDFTLNYDENAFEYVEAISDDGVFVNAKKIE DGKVRVLVSSLTGEPLPAKEVLAKVVLRAEAKTEGSNLSVTNSSVGDGEGLVHEIAGTEK TVNIIEGTSPEIVVNPVRDFKASEINKKNVTVTWTEPETTEGLEGYILYKDGKKVAEIGK DETSYTFKKLNRHTIYNFKIAAKYSNGEVSSKESLTLRTAR
Number of residues	None
Molecular Weight	111107.99
Theoretical pI	4.36
GO Classification	Functions carbohydrate binding beta-N-acetylhexosaminidase activity Processes Components
General Function	Carbohydrate binding
Specific Function	Binds carbohydrates. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins. Can bind and deglycosylate O-glycosylated peptides from mammals. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q8XL08
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0017075\|O-GlcNAcase NagJ (nagJ) ATGAAAAGAAAAATGCTTAAAAGACTTTTAACTTCAGCGTTTGCTTGTATGTTTATTGCA AATGGCTTAATAACTACTACTGTAAGAGCTGTAGGACCTAAAACTGGGGAAGAAAACCAG GTTTTAGTTCCAAATTTAAATCCAACACCAGAAAATTTAGAGGTTGTAGGAGATGGATTT AAGATAACTTCTTCTATAAATTTAGTTGGTGAGGAAGAGGCAGATGAGAATGCAGTAAAT GCTTTAAGGGAATTTTTAACTGCAAACAACATAGAAATAAATAGTGAAAATGATCCAAAT TCAACTACCCTTATAATAGGTGAGGTTGATGATGATATTCCTGAGTTAGATGAAGCTTTA AATGGAACTACAGCAGAAAATTTAAAAGAAGAGGGATATGCTTTAGTTTCAAATGATGGG AAAATAGCTATTGAAGGTAAAGATGGAGATGGAACTTTCTATGGAGTTCAAACATTTAAG CAATTAGTTAAGGAATCTAATATACCAGAAGTGAATATAACTGATTATCCAACAGTTAGT GCTAGGGGTATTGTAGAAGGTTTTTATGGAACTCCTTGGACACATAAAGATAGATTAGAT CAGATTAAATTTTATGGAGAAAATAAATTAAACACATATATTTATGCTCCTAAAGATGAT CCATATCACAGAGAAAAATGGAGAGAGCCATATCCAGAAAATGAAATGCAAAGAATGCAA GAACTTATAGATGCTTCTGCTGAAAATAAGGTTGATTTTGTTTTCGGTATTTCTCCAGGA ATAGATATAAGATTTGATGGAGAAGCAGGAGAAGAAGATTTTAATCATTTAATAGCTAAA GCAGAATCTTTATATGACATGGGTGTAAGAAGTTTTGCAATCTATTGGGATGATATTCAA GATAAGAGTGCAGCTAAACATGCTCAAGTTTTAAATAGATTTAATGAAGAATTTGTAAAG GCTAAGGGAGATGTAAAACCATTAATAACAGTCCCAACAGAGTATGATACTGGAGCTATG GTAAGTAATGGACAACCTAGAACTTATACTAGAATTTTTGCAGAAACTGTTGATCCTAGT ATAGAAGTTATGTGGACTGGTCCTGGAGTTGTTACAAATGAAATTCCTTTAAGTGATGCA CAACTTATAAGTGGAATATACAATAGAAATATGGCAGTATGGTGGAATTATCCAGTAACA GATTATTTTAAAGGTAAGCTTGCCTTAGGACCAATGCATGGATTAGATAAAGGATTAAAT CAATATGTAGATTTCTTTACTGTAAATCCAATGGAGCATGCTGAGCTTTCAAAAATATCA ATACACACAGCTGCTGACTATAGCTGGAATATGGATAACTATGATTATGATAAGGCTTGG AATAGAGCAATTGATATGCTTTATGGTGATTTAGCAGAAGATATGAAGGTATTTGCAAAC CATTCAACAAGAATGGACAATAAAACTTGGGCTAAATCAGGAAGAGAAGACGCTCCAGAG CTTAGAGCAAAAATGGATGAGTTATGGAATAAGTTATCTTCTAAAGAAGATGCAAGTGCT CTTATAGAAGAGTTATATGGAGAGTTTGCAAGAATGGAAGAAGCTTGTAATAATCTAAAG GCAAATTTACCTGAAGTTGCTTTAGAAGAATGCTCAAGACAACTTGATGAACTTATTACT TTAGCTCAAGGGGATAAGGCTTCATTAGATATGATTGTAGCTCAATTAAATGAAGATACA GAGGCTTATGAAAGTGCTAAAGAAATTGCACAAAATAAATTAAATACAGCCTTAAGTAGC TTTGCAGTTATATCTGAAAAGGTTGCTCAATCATTTATACAAGAAGCTTTAAGTTTTGAT TTAACATTAATAAATCCAAGAACAGTAAAGATAACAGCTTCATCTGAAGAGACTTCAGGG GAAAATGCACCAGCTTCCTTTGCTTCAGATGGTGATATGAATACTTTCTGGCATAGTAAA TGGTCATCACCTGCTCATGAAGGTCCTCATCATTTAACTTTAGAATTAGATAATGTATAT GAAATAAATAAAGTTAAATATGCTCCAAGACAAGATAGTAAAAATGGAAGAATAACAGGG TATAAAGTATCTGTTAGTTTAGATGGAGAAAACTTTACAGAAGTTAAAACTGGAACTTTA GAAGATAATGCAGCTATTAAATTTATAGAATTTGATAGTGTTGATGCTAAATATGTAAGA TTAGATGTTACAGATAGCGTTTCAGATCAAGCAAATGGTAGAGGAAAATTTGCTACTGCT GCAGAGGTTAATGTTCATGGAAAGTTAAAAGAAGCTGCTGAGGTAACAGGAAGTGTATCT CTTGAAGCTTTAGAGGAAGTTCAAGTTGGAGAAAACATAGAAGTTGGAGTAGGTATAGAC GAATTAGTAAATGCAGAAGCTTTTGCTTATGATTTTACACTAAATTATGATGAAAATGCC TTTGAATATGTAGAAGCAATTTCTGATGATGGAGTGTTTGTAAATGCTAAGAAAATAGAA GACGGAAAGGTTAGAGTGCTTGTAAGTTCTTTAACTGGAGAACCATTGCCAGCTAAAGAA GTTTTAGCTAAGGTTGTCCTAAGAGCAGAAGCTAAAACAGAAGGAAGCAATTTAAGCGTA ACCAATTCATCAGTTGGAGATGGAGAAGGGTTAGTTCATGAGATTGCAGGAACTGAAAAA ACAGTTAATATAATAGAAGGAACTAGTCCAGAAATTGTTGTAAATCCAGTAAGAGATTTT AAAGCATCAGAAATAAATAAAAAGAATGTAACTGTAACTTGGACAGAACCAGAAACAACA GAAGGCTTAGAAGGATATATTCTTTATAAGGATGGTAAAAAGGTAGCTGAAATAGGCAAG GATGAAACTTCTTATACATTTAAAAAGTTAAATAGACATACAATCTATAACTTTAAGATT GCAGCTAAATATTCAAATGGGGAAGTTTCAAGTAAAGAAAGCCTAACTTTAAGAACTGCA AGATAG
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, Shiba T, Ogasawara N, Hattori M, Kuhara S, Hayashi H: Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. Epub 2002 Jan 15. [11792842 ]

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