Recoverin


NameRecoverin
Synonyms
  • Cancer-associated retinopathy protein
  • Protein CAR
  • RCV1
Gene NameRCVRN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017377|Recoverin
MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDT
DPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKN
EVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANK
EILRLIQFEPQKVKEKMKNA
Number of residuesNone
Molecular Weight23130.085
Theoretical pI4.79
GO Classification
Functions
  • calcium ion binding
  • calcium sensitive guanylate cyclase activator activity
Processes
  • signal transduction
  • visual perception
  • phototransduction, visible light
  • regulation of calcium ion transport
  • positive regulation of guanylate cyclase activity
  • regulation of rhodopsin mediated signaling pathway
  • rhodopsin mediated signaling pathway
Components
General FunctionCalcium sensitive guanylate cyclase activator activity
Specific FunctionSeems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP35243
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0017378|Recoverin (RCVRN)
ATGGGGAACAGCAAAAGTGGGGCCCTGTCCAAGGAGATCCTGGAGGAGCTGCAGCTGAAC
ACCAAGTTCTCGGAGGAGGAGCTGTGCTCCTGGTACCAGTCCTTCCTGAAGGACTGTCCC
ACCGGCCGCATCACCCAGCAGCAGTTCCAGAGCATCTACGCCAAGTTCTTCCCCGACACC
GACCCCAAGGCCTACGCCCAGCATGTGTTCCGCAGCTTCGATTCCAACCTCGACGGCACC
CTGGACTTCAAGGAGTACGTCATCGCCCTGCACATGACCACCGCGGGCAAGACCAACCAG
AAGCTGGAGTGGGCCTTCTCCCTCTACGACGTGGACGGTAACGGGACCATCAGCAAGAAT
GAAGTGCTGGAGATCGTCATGGCTATTTTCAAAATGATCACTCCCGAGGACGTGAAGCTC
CTTCCAGACGATGAAAACACGCCGGAAAAGCGAGCCGAGAAGATCTGGAAGTACTTTGGA
AAGAATGATGATGATAAACTTACAGAGAAAGAATTCATTGAGGGGACACTGGCCAATAAG
GAAATTCTGCGACTGATCCAGTTTGAGCCTCAAAAAGTGAAGGAAAAGATGAAGAACGCC
TGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location17
Locus17p13.1
References
  1. Murakami A, Yajima T, Inana G: Isolation of human retinal genes: recoverin cDNA and gene. Biochem Biophys Res Commun. 1992 Aug 31;187(1):234-44. [1387789 ]
  2. Wiechmann AF, Hammarback JA: Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. Exp Eye Res. 1993 Apr;56(4):463-70. [8500558 ]
  3. Thirkill CE, Tait RC, Tyler NK, Roth AM, Keltner JL: The cancer-associated retinopathy antigen is a recoverin-like protein. Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2768-72. [1388144 ]
  4. Matsubara S, Yamaji Y, Sato M, Fujita J, Takahara J: Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Br J Cancer. 1996 Nov;74(9):1419-22. [8912538 ]
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  6. Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K, Kato S: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Invest Ophthalmol Vis Sci. 2011 Aug 22;52(9):6662-70. doi: 10.1167/iovs.11-7479. [21697133 ]
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