Alpha-pyrone synthesis polyketide synthase-like Pks18

Name	Alpha-pyrone synthesis polyketide synthase-like Pks18
Synonyms	2.3.1.- Alpha-pyrone synthesis polyketide synthase type III Pks18 Chalcone synthase-like protein CHS-like
Gene Name	pks18
Organism	Mycobacterium tuberculosis
Amino acid sequence	>lcl\|BSEQ0051264\|Alpha-pyrone synthesis polyketide synthase-like Pks18 MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELF LDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDV SKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMN ALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQE KLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDN GLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMV QQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Number of residues	None
Molecular Weight	42032.07
Theoretical pI	None
GO Classification	Functions transferase activity, transferring acyl groups other than amino-acyl groups Processes fatty acid biosynthetic process chalcone biosynthetic process Components
General Function	Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
Specific Function	Transferase activity, transferring acyl groups other than amino-acyl groups
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P9WPF1
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0051265\|Alpha-pyrone synthesis polyketide synthase-like Pks18 (pks18) ATGAACGTCTCAGCTGAGAGCGGTGCGCCGCGCCGGGCCGGCCAGAGGCATGAGGTTGGC CTTGCCCAGTTGCCGCCGGCTCCGCCCACCACGGTGGCGGTGATTGAAGGGCTTGCGACG GGCACGCCGCGTCGGGTAGTCAACCAGTCCGACGCCGCCGATCGGGTCGCCGAGCTTTTC CTCGATCCCGGTCAGCGGGAACGGATTCCGCGGGTGTATCAAAAATCGCGGATCACCACG CGCCGGATGGCGGTCGACCCGCTCGACGCCAAATTTGATGTCTTCAGGCGGGAACCTGCG ACGATCCGTGATCGGATGCATCTGTTCTACGAACACGCGGTTCCGCTGGCGGTGGACGTG AGCAAGCGTGCCCTGGCCGGCCTGCCATACCGTGCCGCCGAGATCGGGCTGCTGGTGTTG GCCACCAGCACCGGATTCATCGCGCCGGGCGTGGACGTTGCGATCGTCAAAGAGCTCGGG CTCTCCCCGTCGATATCACGTGTCGTGGTCAATTTCATGGGATGTGCCGCCGCGATGAAT GCCCTGGGCACCGCCACCAACTATGTTCGTGCCCACCCGGCCATGAAGGCGCTGGTGGTG TGTATCGAATTGTGCTCGGTGAACGCTGTTTTTGCCGACGACATCAACGACGTCGTCATT CACAGCTTGTTTGGCGACGGGTGCGCGGCGTTGGTGATCGGCGCCAGCCAGGTTCAGGAG AAGCTCGAGCCAGGCAAGGTGGTAGTCCGCAGTAGTTTCAGTCAGCTGCTCGACAACACC GAAGACGGTATCGTGCTTGGCGTCAATCACAACGGCATCACCTGCGAGCTGTCGGAGAAT CTCCCCGGCTACATCTTCAGCGGGGTCGCACCGGTGGTGACAGAGATGTTATGGGACAAT GGATTACAGATATCCGATATCGATCTCTGGGCGATCCATCCGGGTGGCCCCAAGATCATC GAGCAGTCGGTGCGCTCGCTGGGGATCTCCGCGGAGCTGGCGGCGCAGAGCTGGGACGTG CTCGCCCGCTTCGGCAACATGCTCAGCGTATCGCTTATCTTTGTGCTAGAGACGATGGTG CAGCAGGCGGAGTCGGCCAAAGCCATCTCGACGGGGGTGGCGTTCGCGTTCGGGCCGGGC GTCACTGTCGAAGGCATGCTGTTCGACATCATCCGACGGTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [9634230 ] Saxena P, Yadav G, Mohanty D, Gokhale RS: A new family of type III polyketide synthases in Mycobacterium tuberculosis. J Biol Chem. 2003 Nov 7;278(45):44780-90. Epub 2003 Aug 26. [12941968 ] Sankaranarayanan R, Saxena P, Marathe UB, Gokhale RS, Shanmugam VM, Rukmini R: A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites. Nat Struct Mol Biol. 2004 Sep;11(9):894-900. Epub 2004 Aug 1. [15286723 ]

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