Polyprotein

Name	Polyprotein
Synonyms
Gene Name	None
Organism	Coxsackievirus A21
Amino acid sequence	>lcl\|BSEQ0012958\|Genome polyprotein MGAQVSTQKTGAHENQNVAANGSTINYTTINYYKDSASNSATRQDLSQDPSKFTEPVKDL MLKTAPALNSPNVEACGYSDRVRQITLGNSTITTQEAANAIVAYGEWPTYINDSEANPVD APTEPDVSSNRFYTLESVSWKTTSRGWWWKLPDCLKDMGMFGQNMYYHYLGRSGYTIHVQ CNASKFHQGALGVFLIPEFVMACNTESKTSYVSYINANPGERGGEFTNTYNPSNTDASEG RKFAALDYLLGSGVLAGNAFVYPHQIINLRTNNSATIVVPYVNSLVIDCMAKHNNWGIVI LPLAPLAFAATSSPQVPITVTIAPMCTEFNGLRNITVPVHQGLPTMNTPGSNQFLTSDDF QSPCALPNFDVTPPIHIPGEVKNMMELAEIDTLIPMNAVDGKVNTMEMYQIPLNDNLSKA PIFCLSLSPASDKRLSRTMLGEILNYYTHWTGSIRFTFLFCGSMMATGKLLLSYSPPGAK PPTNRKDAMLGTHIIWDLGLQSSCSMVAPWISNTVYRRCARDDFTEGGFITCFYQTRIVV PASTPTSMFMLGFVSACPDFSVRLLRDTPHISQSKLIGRTQGIEDLIDTAIKNALRVSQP PSTQSTEATSGVNSQEVPALTAVETGASGQAIPSDVVETRHVVNYKTRSESCLESFFGRA ACVTILSLTNSSKSGEEKKHFNIWNITYTDTVQLRRKLEFFTYSRFDLEMTFVFTENYPS TASGEVRNQVYQIMYIPPGAPRPSSWDDYTWQSSSNPSIFYMYGNAPPRMSIPYVGIANA YSHFYDGFARVPLEGENTDAGDTFYGLVSINDFGVLAVRAVNRSNPHTIHTSVRVYMKPK HIRCWCPRPPRAVLYRGEGVDMISSAILPLTKVDSITTFGFGHQNKAVYVAGYKICNYHL ATPSDHLNAISMLWDRDLMVVESRAQGTDTIARCSCRCGVYYCESRRKYYPVTFTGPTFR FMEANDYYPARYQSHMLIGCGFAEPGDCGGILRCTHGVIGIITAGGEGVVAFADIRDLWV YEEEAMEQGITSYIESLGTAFGAGFTHTISEKVTELTTMVTSTITEKLLKNLVKIVSALV IVVRNYEDTTTILATLALLGCDISPWQWLKKKACDLLEIPYVMRQGDGWMKKFTEACNAA KGLEWISNKISKFIDWLKCKIIPDAKDKVEFLTKLKQLDMLENQIATIHQSCPSQEQQEI LFNNVRWLAVQSRRFAPLYAVEARRINKMESTINNYIQFKSKHRIEPVCMLIHGSPGTGK SIATSLIGRAIAEKESTSVYSMPPDPSHFDGYKQQGVVIMDDLNQNPDGMDMKLFCQMVS TVEFIPPMASLEEKGILFTSDYVLASTNSHSIVPPTVAHSDALTRRFAFDVEVYTMSEHS VKGKLNMATATQLCKDCPTPANFKKCCPLVCGKALQLMDRYTRQRFTVDEITTLIMNEKN RRANIGNCMEALFQGPLRYKDLKIDVKTVPPPECISDLLQAVDSQEVRDYCEKKGWIVNV TSQIQLERNINRAMTILQAVTTFAAVAGVVYVMYKLFAGQQGAYTGLPNKKPNVPTIRVA KVQGPGFDYAVAMAKRNIVTATTTKGEFTMLGVHDNVAILPTHAAPGETIIIDGKEVEIL DARALEDQAGTNLEITIITLKRNEKFRDIRSHIPTQITETNDGVLIVNTSKYPNMYVPVG AVTEQGYLNLSGRQTARTLMYNFPTRAGQCGGIITCTGKVIGMHVGGNGSHGFAAALKRS YFTQNQGEIQWMRSSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDF EEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQMCLEDAMYGTDGLEALDLST SAGYPYVAMGKKKRDILDKQTRDTKEMQRLLDTYGINLPLVTYVKDELRSKTKVEQGKSR LIEASSLNDSVAMRMAFGNLYAAFHKNPGVVTGSAVGCDPDLFWSKIPVLMEEKLFAFDY TGYDASLSPAWFEALKMVLEKIGFGSRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTS IFNSMINNLIIRTLLLRTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQSGKDYGLTM TPADKSVTFETVTWENVTFLKRFFRADEKYPFLVHPVMPMKEIHESIRWTKDPRNTQDHV RSLCLLAWHNGEEEYNKFLAKIRSVPIGRALLLPEYSTLYRRWLDSF
Number of residues	None
Molecular Weight	246035.23
Theoretical pI	7.13
GO Classification	Functions ion channel activity ATP binding RNA binding structural molecule activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity RNA helicase activity Processes viral entry into host cell protein oligomerization pore formation by virus in membrane of host cell virion attachment to host cell RNA-protein covalent cross-linking transcription, DNA-templated viral RNA genome replication Components membrane integral to membrane of host cell host cell cytoplasmic vesicle viral capsid
General Function	Structural molecule activity
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q71LY2
UniProtKB Entry Name
Cellular Location	Host cytoplasm
Gene sequence	>lcl\|BSEQ0008065\|6624 bp ATGGGGGCTCAAGTTTCAACGCAAAAGACCGGTGCGCACGAGAATCAAAACGTGGCAGCC AATGGATCCACCATTAATTACACTACTATCAACTATTACAAAGACAGTGCGAGTAATTCC GCTACTAGACAAGACCTCTCCCAAGATCCATCAAAATTCACAGAACCGGTTAAGGACTTA ATGTTGAAAACAGCACCAGCTCTAAACTCGCCTAACGTGGAAGCATGTGGGTACAGTGAC CGTGTGAGGCAAATCACTTTAGGCAACTCGACTATTACTACACAAGAAGCAGCCAATGCT ATTGTTGCTTACGGTGAATGGCCCACTTACATAAATGATTCAGAAGCTAATCCGGTAGAT GCACCCACTGAGCCAGACGTTAGTAGCAACCGGTTTTACACCCTAGAATCGGTGTCTTGG AAGACCACTTCAAGGGGATGGTGGTGGAAGTTACCAGATTGTTTGAAGGACATGGGAATG TTTGGTCAGAATATGTACTATCACTACTTGGGGCGCTCTGGTTACACCATTCATGTCCAG TGCAACGCTTCAAAATTTCACCAAGGGGCGTTAGGAGTTTTTCTGATACCAGAGTTTGTC ATGGCTTGCAACACTGAGAGTAAAACGTCATACGTTTCATACATCAATGCAAATCCTGGT GAGAGAGGCGGTGAGTTTACGAACACCTACAATCCGTCAAATACAGACGCCAGTGAGGGC AGAAAGTTTGCAGCATTGGATTATTTGCTGGGTTCTGGTGTTCTAGCAGGAAACGCCTTT GTGTACCCGCACCAGATCATCAACCTACGTACCAACAACAGTGCAACAATTGTGGTGCCA TACGTAAACTCACTTGTGATTGATTGTATGGCAAAACACAATAACTGGGGCATTGTCATA TTACCACTGGCACCCTTGGCCTTTGCCGCAACATCGTCACCACAGGTGCCTATTACAGTG ACCATTGCACCCATGTGTACAGAATTCAATGGGTTGAGAAACATCACCGTCCCAGTACAT CAAGGGTTGCCGACAATGAACACACCTGGTTCCAATCAATTCCTTACATCTGATGACTTC CAGTCGCCCTGTGCCTTACCTAATTTTGATGTTACTCCACCAATACACATACCCGGGGAA GTAAAGAATATGATGGAACTAGCTGAAATTGACACATTGATCCCAATGAACGCAGTGGAC GGGAAGGTGAACACAATGGAGATGTATCAAATACCATTGAATGACAATTTGAGCAAGGCA CCTATATTCTGTTTATCCCTATCACCTGCTTCTGATAAACGACTGAGCCGCACCATGTTG GGTGAAATCCTAAATTATTACACCCATTGGACGGGGTCCATCAGGTTCACCTTTCTATTT TGTGGTAGTATGATGGCCACTGGTAAACTGCTCCTCAGCTATTCCCCACCGGGAGCTAAA CCACCAACCAATCGCAAGGATGCAATGCTAGGCACACACATCATCTGGGACCTAGGGTTA CAATCCAGTTGTTCCATGGTTGCACCGTGGATCTCCAACACAGTGTACAGACGGTGTGCA CGTGATGACTTCACTGAGGGCGGATTTATAACTTGCTTCTATCAAACTAGAATTGTGGTA CCTGCTTCAACCCCTACCAGTATGTTCATGTTAGGCTTTGTTAGTGCGTGTCCAGACTTC AGTGTCAGACTGCTTAGGGACACTCCCCATATTAGTCAATCGAAACTAATAGGACGTACA CAAGGCATTGAAGACCTCATTGACACAGCGATAAAGAATGCCTTAAGAGTGTCCCAACCA CCCTCGACCCAGTCAACTGAAGCAACTAGTGGAGTGAATAGCCAGGAGGTGCCAGCTCTA ACTGCTGTGGAAACAGGAGCATCTGGTCAAGCAATCCCCAGTGATGTGGTGGAAACTAGG CACGTGGTAAATTACAAAACCAGGTCTGAATCGTGTCTTGAGTCATTCTTTGGGAGAGCT GCGTGTGTCACAATCCTATCCTTGACCAACTCCTCCAAGAGCGGAGAGGAGAAAAAGCAT TTCAACATATGGAATATTACATACACCGACACTGTCCAGTTACGCAGAAAATTAGAGTTT TTCACGTATTCCAGGTTTGATCTTGAAATGACTTTTGTATTCACAGAGAACTATCCTAGT ACAGCCAGTGGAGAAGTGCGAAACCAGGTGTACCAGATCATGTATATTCCACCAGGGGCA CCCCGCCCATCATCCTGGGATGACTACACATGGCAATCCTCTTCAAACCCTTCCATCTTC TACATGTATGGAAATGCACCTCCACGGATGTCAATTCCTTACGTAGGGATTGCCAATGCC TATTCACACTTCTACGATGGCTTTGCACGGGTGCCACTTGAGGGTGAGAACACCGATGCT GGCGACACGTTTTACGGTTTAGTGTCCATAAATGATTTTGGAGTTTTAGCAGTTAGAGCA GTAAACCGCAGTAATCCACATACAATACACACATCTGTGAGAGTGTACATGAAACCAAAA CACATTCGGTGTTGGTGCCCCAGACCTCCTCGAGCTGTATTATACAGGGGAGAGGGAGTG GACATGATATCCAGTGCAATTCTACCTCTGACCAAGGTAGACTCAATTACCACTTTTGGG TTTGGTCATCAGAACAAAGCAGTGTACGTTGCCGGTTACAAGATTTGCAACTACCACCTA GCAACCCCAAGTGATCACTTGAATGCAATTAGTATGTTATGGGACAGGGATTTAATGGTG GTGGAATCTAGAGCCCAGGGAACTGATACCATCGCCAGATGTAGTTGCAGGTGTGGAGTT TACTATTGTGAATCTAGGAGGAAGTACTACCCTGTCACTTTTACTGGCCCAACGTTTCGA TTCATGGAAGCAAACGACTACTATCCAGCAAGATACCAGTCTCACATGCTGATAGGGTGC GGATTTGCAGAACCCGGGGACTGCGGTGGGATACTGAGGTGCACTCATGGGGTAATTGGT ATCATTACTGCAGGAGGTGAAGGGGTAGTAGCCTTTGCTGACATTAGAGACCTCTGGGTG TATGAAGAGGAGGCCATGGAACAGGGAATAACAAGCTACATCGAATCTCTCGGCACAGCC TTTGGCGCAGGGTTCACCCACACAATCAGTGAGAAAGTGACTGAATTGACAACAATGGTT ACCAGCACTATCACAGAAAAACTACTGAAAAACTTGGTGAAAATAGTGTCGGCTCTAGTG ATTGTTGTGAGAAATTATGAGGACACTACCACGATCCTTGCAACACTAGCACTACTCGGG TGTGATATATCTCCTTGGCAATGGTTGAAGAAGAAGGCATGTGACTTACTAGAGATTCCT TATGTGATGCGCCAAGGTGATGGGTGGATGAAGAAATTCACAGAGGCGTGCAATGCAGCT AAAGGCTTAGAGTGGATTAGCAACAAAATTTCCAAGTTTATAGATTGGTTGAAGTGTAAA ATTATCCCAGACGCTAAGGACAAGGTGGAATTTCTCACCAAGTTGAAACAGCTAGACATG TTGGAAAATCAAATTGCAACCATCCACCAATCTTGCCCCAGCCAAGAACAACAAGAGATT CTTTTCAACAATGTGAGATGGCTAGCAGTCCAGTCCCGTCGGTTTGCACCATTATACGCT GTGGAGGCACGCCGAATTAACAAAATGGAGAGCACAATAAACAATTATATACAGTTCAAG AGCAAACACCGTATTGAACCAGTATGTATGCTCATTCATGGGTCACCAGGGACGGGTAAA TCTATAGCTACTTCATTAATAGGTAGAGCAATAGCAGAGAAGGAAAGCACATCAGTCTAT TCAATGCCACCTGACCCATCTCACTTTGATGGCTATAAACAACAAGGGGTAGTGATTATG GACGACCTAAACCAAAACCCCGATGGTATGGACATGAAACTGTTTTGCCAAATGGTATCA ACAGTGGAGTTTATTCCTCCAATGGCCTCATTAGAGGAGAAGGGCATTTTGTTTACATCT GATTATGTCCTGGCTTCTACCAACTCTCATTCAATTGTACCACCCACAGTGGCTCACAGT GATGCCTTAACCAGACGATTTGCATTTGATGTGGAGGTTTACACGATGTCTGAACATTCA GTCAAAGGCAAACTGAATATGGCCACGGCCACTCAATTGTGTAAGGATTGTCCAACACCT GCAAATTTTAAAAAGTGTTGCCCTCTCGTTTGTGGAAAGGCCTTGCAATTAATGGACAGG TACACCAGACAAAGGTTCACTGTAGATGAGATTACCACATTAATCATGAATGAGAAAAAC AGAAGGGCCAATATCGGCAATTGCATGGAAGCCTTGTTTCAAGGACCATTAAGGTATAAA GATTTGAAGATCGATGTGAAGACAGTTCCCCCCCCTGAGTGCATCAGTGATTTGTTACAA GCAGTGGATTCTCAAGAGGTTAGGGATTACTGTGAGAAGAAAGGCTGGATCGTTAACGTT ACTAGCCAGATTCAACTAGAAAGGAACATCAATAGGGCCATGACTATACTCCAAGCTGTT ACCACATTCGCAGCAGTCGCAGGAGTAGTGTATGTAATGTACAAACTCTTCGCCGGTCAA CAGGGTGCATACACTGGCTTGCCAAACAAAAAACCCAATGTCCCTACTATCAGAGTCGCT AAAGTCCAGGGGCCAGGATTTGACTACGCAGTGGCAATGGCAAAAAGAAACATAGTTACT GCAACCACCACCAAGGGTGAATTTACCATGCTAGGGGTGCATGATAATGTAGCAATATTG CCAACCCATGCCGCTCCAGGAGAAACCATTATTATTGATGGGAAAGAAGTAGAGATCCTA GATGCCAGAGCCTTAGAAGATCAAGCGGGAACCAATCTTGAGATCACCATTATTACTCTA AAAAGAAATGAGAAGTTTAGAGACATCAGATCACATATTCCCACCCAAATTACTGAAACT AACGATGGAGTGTTGATCGTGAACACTAGCAAGTACCCCAATATGTATGTCCCCGTTGGT GCTGTGACCGAACAGGGATATCTTAATCTCAGTGGACGTCAAACTGCTCGCACTTTAATG TACAACTTTCCAACAAGGGCAGGCCAGTGCGGAGGAATCATCACTTGTACTGGCAAAGTC ATTGGGATGCATGTTGGCGGGAACGGTTCACATGGGTTTGCAGCAGCCCTCAAGCGATCA TACTTCACTCAAAATCAGGGCGAAATCCAGTGGATGAGGTCATCAAAAGAAGTGGGGTAC CCCATTATAAATGCCCCATCCAAGACAAAGTTAGAACCCAGTGCTTTCCACTATGTTTTT GAAGGTGTTAAGGAACCAGCTGTACTCACTAAGAATGACCCCAGACTAAAAACAGATTTT GAAGAAGCCATCTTTTCTAAATATGTGGGGAACAAAATTACTGAAGTGGACGAGTACATG AAAGAAGCAGTGGATCACTATGCAGGACAGTTAATGTCACTGGATATCAACACAGAACAG ATGTGCCTGGAGGATGCCATGTACGGCACCGATGGTCTTGAGGCCCTGGATCTTAGCACT AGTGCTGGATATCCTTATGTTGCAATGGGGAAAAAGAAAAGAGACATTCTAGATAAACAG ACCAGAGATACTAAGGAGATGCAGAGACTTTTAGATACCTATGGAATCAATCTACCATTA GTCACGTACGTGAAAGATGAACTCAGGTCAAAGACTAAAGTGGAACAAGGAAAGTCAAGA TTGATTGAAGCTTCCAGCCTTAATGATTCAGTTGCAATGAGAATGGCCTTTGGCAATCTT TACGCAGCTTTCCACAAGAATCCAGGTGTGGTGACAGGATCAGCAGTTGGTTGTGACCCA GATTTGTTTTGGAGTAAGATACCAGTGCTAATGGAAGAAAAACTCTTCGCTTTTGACTAC ACAGGGTATGATGCCTCACTCAGCCCTGCTTGGTTTGAAGCTCTTAAAATGGTGTTAGAA AAAATTGGATTTGGCAGTAGAGTAGACTATATAGACTACCTGAACCACTCTCACCACCTT TACAAAAACAAGACTTATTGTGTCAAAGGCGGCATGCCATCCGGCTGCTCTGGCACCTCA ATTTTCAACTCAATGATTAACAACCTGATCATTAGGACGCTTTTACTGAGAACCTACAAG GGCATAGACTTGGACCATTTAAAAATGATTGCCTATGGTGATGACGTGATAGCTTCCTAC CCCCATGAGGTTGACGCTAGTCTCCTAGCCCAATCAGGAAAAGACTATGGACTAACCATG ACTCCAGCAGATAAATCAGTAACCTTTGAAACAGTCACATGGGAGAATGTAACATTTCTG AAAAGATTTTTCAGAGCAGATGAGAAGTATCCATTCCTGGTGCATCCAGTGATGCCAATG AAAGAAATTCACGAATCAATCAGATGGACCAAGGACCCTAGAAACACACAGGATCACGTA CGCTCGTTGTGCCTATTAGCTTGGCACAACGGTGAAGAAGAATACAATAAATTTTTAGCT AAAATCAGAAGTGTGCCAATCGGAAGAGCTTTATTGCTCCCAGAGTACTCTACATTGTAC CGCCGATGGCTCGACTCATTTTAG
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Newcombe NG, Andersson P, Johansson ES, Au GG, Lindberg AM, Barry RD, Shafren DR: Cellular receptor interactions of C-cluster human group A coxsackieviruses. J Gen Virol. 2003 Nov;84(Pt 11):3041-50. [14573809 ]

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