ADP-ribosylation factor 6

NameADP-ribosylation factor 6
Synonyms
Gene NameARF6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019545|ADP-ribosylation factor 6
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFN
VWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIF
ANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
Number of residuesNone
Molecular Weight20082.01
Theoretical pI9.32
GO Classification
Functions
  • GTP binding
  • GTPase activity
  • thioesterase binding
Processes
  • ruffle organization
  • negative regulation of dendrite development
  • protein localization to cell surface
  • establishment of epithelial cell polarity
  • cell adhesion
  • negative regulation of receptor-mediated endocytosis
  • cortical actin cytoskeleton organization
  • protein transport
  • regulation of filopodium assembly
  • movement of cell or subcellular component
  • myeloid cell apoptotic process
  • small GTPase mediated signal transduction
  • protein localization to endosome
  • liver development
  • positive regulation of establishment of protein localization to plasma membrane
  • cell division
  • regulation of Rac protein signal transduction
  • positive regulation of actin filament polymerization
  • cell cycle
  • hepatocyte apoptotic process
  • vesicle-mediated transport
  • regulation of dendritic spine development
Components
  • membrane
  • extracellular exosome
  • myelin sheath
  • midbody
  • endosome
  • endocytic vesicle
  • ruffle
  • recycling endosome membrane
  • plasma membrane
  • focal adhesion
  • cleavage furrow
  • filopodium membrane
  • early endosome
  • cell cortex
  • Golgi apparatus
General FunctionThioesterase binding
Specific FunctionGTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP62330
UniProtKB Entry Name
Cellular LocationGolgi apparatus
Gene sequence
>lcl|BSEQ0019546|ADP-ribosylation factor 6 (ARF6)
ATGGGGAAGGTGCTATCCAAAATCTTCGGGAACAAGGAAATGCGGATCCTCATGTTGGGC
CTGGACGCGGCCGGCAAGACAACAATCCTGTACAAGTTGAAGCTGGGCCAGTCGGTGACC
ACCATTCCCACTGTGGGTTTCAACGTGGAGACGGTGACTTACAAAAATGTCAAGTTCAAC
GTATGGGATGTGGGCGGCCAGGACAAGATCCGGCCGCTCTGGCGGCATTACTACACTGGG
ACCCAAGGTCTCATCTTCGTAGTGGACTGCGCCGACCGCGACCGCATCGATGAGGCTCGC
CAGGAGCTGCACCGCATTATCAATGACCGGGAGATGAGGGACGCCATAATCCTCATCTTC
GCCAACAAGCAGGACCTGCCCGATGCCATGAAACCCCACGAGATCCAGGAGAAACTGGGC
CTGACCCGGATTCGGGACAGGAACTGGTATGTGCAGCCCTCCTGTGCCACCTCAGGGGAC
GGACTCTATGAGGGGCTCACATGGTTAACCTCTAACTACAAATCTTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location14
Locus14q21.3
References
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