Serum amyloid P-component


NameSerum amyloid P-component
Synonyms
  • 9.5S alpha-1-glycoprotein
  • PTX2
  • SAP
Gene NameAPCS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016353|Serum amyloid P-component
MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYS
DLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESS
SGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWD
SVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
Number of residuesNone
Molecular Weight25386.92
Theoretical pI6.52
GO Classification
Functions
  • calcium ion binding
  • virion binding
  • carbohydrate binding
  • complement component C1q binding
  • unfolded protein binding
Processes
  • negative regulation by host of viral exo-alpha-sialidase activity
  • negative regulation by host of viral glycoprotein metabolic process
  • acute-phase response
  • negative regulation of exo-alpha-sialidase activity
  • negative regulation of wound healing
  • negative regulation of glycoprotein metabolic process
  • negative regulation of acute inflammatory response
  • protein folding
  • chaperone-mediated protein complex assembly
  • negative regulation of viral entry into host cell
  • negative regulation of viral process
  • innate immune response
  • negative regulation of monocyte differentiation
  • cellular protein metabolic process
Components
  • protein complex
  • blood microparticle
  • extracellular region
  • nucleus
  • extracellular space
  • extracellular exosome
General FunctionVirion binding
Specific FunctionCan interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP02743
UniProtKB Entry Name
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016354|Serum amyloid P-component (APCS)
ATGAACAAGCCGCTGCTTTGGATCTCTGTCCTCACCAGCCTCCTGGAAGCCTTTGCTCAC
ACAGACCTCAGTGGGAAGGTGTTTGTATTTCCTAGAGAATCTGTTACTGATCATGTAAAC
TTGATCACACCGCTGGAGAAGCCTCTACAGAACTTTACCTTGTGTTTTCGAGCCTATAGT
GATCTCTCTCGTGCCTACAGCCTCTTCTCCTACAATACCCAAGGCAGGGATAATGAGCTA
CTAGTTTATAAAGAAAGAGTTGGAGAGTATAGTCTATACATTGGAAGACACAAAGTTACA
TCCAAAGTTATCGAAAAGTTCCCGGCTCCAGTGCACATCTGTGTGAGCTGGGAGTCCTCA
TCAGGTATTGCTGAATTTTGGATCAATGGGACACCTTTGGTGAAAAAGGGTCTGCGACAG
GGTTACTTTGTAGAAGCTCAGCCCAAGATTGTCCTGGGGCAGGAACAGGATTCCTATGGG
GGCAAGTTTGATAGGAGCCAGTCCTTTGTGGGAGAGATTGGGGATTTGTACATGTGGGAC
TCTGTGCTGCCCCCAGAAAATATCCTGTCTGCCTATCAGGGTACCCCTCTCCCTGCCAAT
ATCCTGGACTGGCAGGCTCTGAACTATGAAATCAGAGGATATGTCATCATCAAACCCTTG
GTGTGGGTCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location1
Locus1q21-q23
References
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  2. Ohnishi S, Maeda S, Shimada K, Arao T: Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component. J Biochem. 1986 Oct;100(4):849-58. [3029048 ]
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