Inter-alpha-trypsin inhibitor heavy chain H2

NameInter-alpha-trypsin inhibitor heavy chain H2
Synonyms
  • IGHEP2
  • Inter-alpha-trypsin inhibitor complex component II
  • ITI heavy chain H2
  • Serum-derived hyaluronan-associated protein
  • SHAP
Gene NameITIH2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049832|Inter-alpha-trypsin inhibitor heavy chain H2
MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGES
EEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFS
MTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFE
LHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVI
SKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFA
PDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRN
DLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVS
DGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQ
DTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQ
IESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAP
TAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSK
VVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNI
DSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETI
TLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVD
FLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGL
QKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP
Number of residuesNone
Molecular Weight106462.725
Theoretical pINone
GO Classification
Functions
  • endopeptidase inhibitor activity
  • serine-type endopeptidase inhibitor activity
Processes
  • hyaluronan metabolic process
Components
  • extracellular region
  • extracellular exosome
  • blood microparticle
General FunctionMay act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Specific FunctionEndopeptidase inhibitor activity
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP19823
UniProtKB Entry Name
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0049833|Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)
ATGAAAAGACTCACGTGCTTTTTCATCTGCTTCTTTCTTTCTGAAGTATCAGGCTTCGAA
ATCCCCATAAATGGACTTTCTGAATTTGTAGACTATGAAGATCTTGTGGAACTGGCCCCA
GGCAAATTTCAATTGGTGGCAGAGAACCGGAGATATCAGAGAAGCCTTCCAGGAGAATCG
GAAGAAATGATGGAAGAGGTTGATCAAGTAACTCTTTATAGCTATAAAGTCCAGTCTACT
ATTACTTCTCGGATGGCCACCACCATGATCCAGAGCAAAGTGGTGAACAATTCCCCGCAG
CCTCAGAATGTCGTGTTTGATGTTCAGATCCCCAAAGGAGCATTCATTTCCAACTTCTCC
ATGACTGTGGACGGCAAGACATTTAGGAGCTCTATTAAGGAGAAAACTGTGGGCCGAGCT
CTTTATGCACAGGCCAGAGCAAAAGGCAAGACGGCTGGCTTGGTGAGGAGCAGCGCTCTT
GATATGGAAAACTTCAGAACGGAAGTAAATGTCCTCCCAGGAGCAAAGGTGCAGTTCGAA
CTTCACTACCAGGAGGTGAAGTGGAGGAAGCTGGGCTCCTATGAGCACAGGATCTATCTG
CAACCTGGACGGCTGGCCAAACACTTAGAGGTAGATGTGTGGGTTATCGAACCACAGGGA
CTGAGATTTCTTCATGTTCCCGACACATTTGAAGGCCATTTCGATGGTGTTCCGGTCATT
TCTAAAGGACAACAGAAGGCGCACGTCTCCTTCAAGCCCACGGTAGCACAGCAGAGAATA
TGCCCTAACTGCCGGGAGACTGCGGTAGATGGGGAACTGGTGGTGCTGTATGACGTGAAA
AGAGAAGAGAAGGCTGGTGAACTGGAGGTGTTTAATGGATATTTTGTCCACTTCTTTGCT
CCTGACAACCTGGACCCAATTCCCAAAAACATCCTCTTTGTCATCGATGTGAGTGGCTCC
ATGTGGGGAGTTAAAATGAAACAAACTGTGGAAGCAATGAAGACCATATTGGATGACCTC
AGAGCAGAAGACCATTTCTCTGTGATTGATTTCAACCAGAACATTCGAACTTGGAGAAAT
GATTTAATTTCAGCTACAAAAACACAGGTTGCAGATGCCAAGAGGTATATTGAGAAAATC
CAGCCCAGTGGAGGCACAAACATCAACGAAGCACTCCTACGGGCAATCTTCATTTTGAAT
GAAGCCAATAACTTGGGACTGTTAGACCCCAACTCCGTCTCGCTGATCATTTTGGTTTCT
GATGGAGATCCAACAGTGGGCGAACTAAAACTGTCAAAAATTCAGAAAAACGTTAAGGAG
AACATCCAAGACAATATCTCCTTGTTCAGTTTGGGCATGGGATTTGATGTGGACTATGAT
TTTTTGAAGAGACTGTCCAATGAAAACCATGGAATTGCACAAAGGATTTATGGAAACCAG
GACACGTCTTCCCAGCTTAAGAAATTCTACAACCAGGTCTCCACTCCATTGCTCCGGAAT
GTTCAGTTCAACTATCCCCATACATCAGTCACGGACGTCACTCAAAACAATTTCCATAAC
TACTTTGGAGGCTCAGAGATTGTGGTGGCAGGAAAATTTGACCCTGCTAAATTGGATCAA
ATAGAGAGCGTTATCACGGCGACTTCGGCTAACACGCAGTTAGTCTTGGAGACCCTGGCC
CAGATGGACGACTTGCAGGATTTTCTATCGAAAGACAAGCATGCAGATCCCGATTTCACC
AGGAAACTGTGGGCCTATCTAACCATCAACCAACTGCTAGCTGAACGAAGCCTGGCTCCT
ACAGCTGCCGCCAAGAGAAGAATTACAAGATCGATCCTGCAGATGTCTCTAGACCACCAC
ATTGTGACTCCGCTGACCTCGCTGGTGATCGAGAACGAGGCTGGGGATGAGCGCATGCTG
GCGGATGCCCCACCGCAGGATCCCTCCTGCTGCTCAGGGGCCCTGTATTACGGCAGCAAA
GTGGTTCCAGATTCCACCCCGTCTTGGGCCAATCCTTCACCAACGCCCGTGATCTCCATG
CTGGCACAAGGATCTCAGGTGCTAGAGTCCACGCCACCCCCACATGTGATGAGAGTTGAA
AATGACCCACATTTCATCATTTATCTACCAAAAAGCCAAAAGAACATTTGTTTCAATATT
GACTCAGAACCTGGAAAAATCCTCAACCTGGTTTCTGACCCAGAATCAGGAATTGTAGTC
AACGGTCAGCTTGTTGGTGCCAAGAAGCCCAACAATGGAAAACTAAGCACCTATTTTGGA
AAACTGGGATTTTATTTCCAAAGTGAAGACATAAAAATAGAAATCAGCACTGAGACCATC
ACCCTGAGCCATGGTTCTAGCACATTCTCCTTGTCCTGGTCCGACACGGCTCAAGTCACG
AATCAGAGGGTGCAGATCTCAGTGAAGAAAGAAAAAGTGGTAACTATCACCCTGGATAAA
GAGATGTCCTTTTCTGTTTTACTTCATCGTGTTTGGAAGAAGCATCCCGTCAATGTTGAC
TTTCTGGGAATCTACATACCCCCTACAAACAAGTTCTCACCTAAAGCCCACGGACTAATA
GGCCAGTTCATGCAGGAACCAAAGATACACATCTTCAATGAGAGACCAGGAAAGGACCCT
GAGAAGCCAGAGGCCAGCATGGAAGTGAAGGGGCAGAAGCTGATCATCACCAGGGGCTTA
CAGAAAGACTACAGAACGGATCTAGTGTTTGGAACGGACGTTACCTGCTGGTTTGTGCAC
AACAGTGGAAAAGGATTCATTGACGGGCATTACAAGGATTACTTCGTGCCTCAGCTCTAC
AGCTTTCTCAAACGGCCTTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location10
Locus10p14
References
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  3. Salier JP, Diarra-Mehrpour M, Sesboue R, Bourguignon J, Benarous R, Ohkubo I, Kurachi S, Kurachi K, Martin JP: Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8272-6. [2446322 ]
  4. Salier JP, Diarra-Mehrpour M, Sesboue R, Bourguignon J, Martin JP: Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain. Biol Chem Hoppe Seyler. 1988 May;369 Suppl:15-8. [2462430 ]
  5. Schreitmuller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W: cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins. Biol Chem Hoppe Seyler. 1987 Aug;368(8):963-70. [3663330 ]
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  8. Enghild JJ, Salvesen G, Thogersen IB, Valnickova Z, Pizzo SV, Hefta SA: Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. J Biol Chem. 1993 Apr 25;268(12):8711-6. [7682553 ]
  9. Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J: TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. Biochemistry. 1994 Jun 14;33(23):7423-9. [7516184 ]
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