Amyloid-like protein 1

NameAmyloid-like protein 1
Synonyms
  • APLP
Gene NameAPLP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049893|Amyloid-like protein 1
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC
GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC
GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA
CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA
EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM
PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT
LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE
QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ
IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM
NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM
LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
Number of residuesNone
Molecular Weight72175.825
Theoretical pINone
GO Classification
Functions
  • transition metal ion binding
  • alpha-2A adrenergic receptor binding
  • alpha-2C adrenergic receptor binding
  • alpha-2B adrenergic receptor binding
  • identical protein binding
  • heparin binding
Processes
  • cell adhesion
  • endocytosis
  • negative regulation of cAMP biosynthetic process
  • cellular response to norepinephrine stimulus
  • animal organ morphogenesis
  • apoptotic process
  • nervous system development
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Components
  • plasma membrane
  • basement membrane
  • integral component of membrane
  • perinuclear region of cytoplasm
General FunctionMay play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Specific FunctionAlpha-2a adrenergic receptor binding
Transmembrane Regions581-603
GenBank Protein ID
UniProtKB IDP51693
UniProtKB Entry Name
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0049894|Amyloid-like protein 1 (APLP1)
ATGGGGCCCGCCAGCCCCGCTGCTCGCGGTCTAAGTCGCCGCCCGGGCCAGCCGCCGCTG
CCGCTGCTGCTGCCACTATTGCTGCTGCTTCTGCGCGCGCAGCCCGCCATCGGGAGCCTG
GCCGGTGGGAGCCCCGGCGCGGCCGAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGC
GGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGC
TCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCG
GAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGC
GGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGC
CTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCAC
CAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCC
TGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGAT
CGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGG
ACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCT
GAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCT
CCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTG
GTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATG
CCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGT
AGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAG
AACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACT
CTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTC
ATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAG
GCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAG
CAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAG
AAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTG
AATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAA
ATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCT
GGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCC
ATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATG
AACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTC
CACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAG
GCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATG
CTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGAC
CCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAAC
CCCACTTACCGCTTCCTGGAGGAACGACCCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location19
Locus19q13.12
References
  1. Paliga K, Peraus G, Kreger S, Durrwang U, Hesse L, Multhaup G, Masters CL, Beyreuther K, Weidemann A: Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. Eur J Biochem. 1997 Dec 1;250(2):354-63. [9428684 ]
  2. Lenkkeri U, Kestila M, Lamerdin J, McCready P, Adamson A, Olsen A, Tryggvason K: Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. Hum Genet. 1998 Feb;102(2):192-6. [9521588 ]
  3. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [15057824 ]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [15489334 ]
  5. Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB: Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res. 1995 Aug;32(1):36-44. [7494461 ]
  6. Bush AI, Pettingell WH Jr, de Paradis M, Tanzi RE, Wasco W: The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem. 1994 Oct 28;269(43):26618-21. [7929392 ]
  7. Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem. 1999 Jan 22;274(4):2243-54. [9890987 ]
  8. Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, Masters CL, White AR, Cappai R, Beyreuther K, Bayer TA, Multhaup G: Evidence for a copper-binding superfamily of the amyloid precursor protein. Biochemistry. 2002 Jul 30;41(30):9310-20. [12135352 ]
  9. Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [19838169 ]
  10. Halim A, Ruetschi U, Larson G, Nilsson J: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. J Proteome Res. 2013 Feb 1;12(2):573-84. doi: 10.1021/pr300963h. Epub 2013 Jan 11. [23234360 ]
  11. Lee S, Xue Y, Hu J, Wang Y, Liu X, Demeler B, Ha Y: The E2 domains of APP and APLP1 share a conserved mode of dimerization. Biochemistry. 2011 Jun 21;50(24):5453-64. doi: 10.1021/bi101846x. Epub 2011 May 26. [21574595 ]

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