Calcium and integrin-binding protein 1

NameCalcium and integrin-binding protein 1
Synonyms
  • Calcium- and integrin-binding protein
  • Calmyrin
  • CIB
  • CIBP
  • DNA-PKcs-interacting protein
  • Kinase-interacting protein
  • KIP
  • PRKDCIP
  • SIP2-28
  • SNK-interacting protein 2-28
Gene NameCIB1
OrganismHomo sapiens
Amino acid sequence
>lcl|BSEQ0049476|Calcium and integrin-binding protein 1
MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILS
LPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDD
GTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRS
PDFASSFKIVL
Number of residuesNone
Molecular Weight21703.07
Theoretical pINone
GO Classification
Functions
  • calcium-dependent protein kinase inhibitor activity
  • ion channel binding
  • protein serine/threonine kinase inhibitor activity
  • calcium ion binding
  • protein C-terminus binding
  • protein kinase binding
  • protein anchor
  • Ras GTPase binding
Processes
  • apoptotic process
  • positive regulation of cell adhesion mediated by integrin
  • negative regulation of protein kinase B signaling
  • positive regulation of NF-kappaB transcription factor activity
  • negative regulation of apoptotic process
  • positive regulation of substrate adhesion-dependent cell spreading
  • positive regulation of establishment of protein localization to plasma membrane
  • positive regulation of protein serine/threonine kinase activity
  • negative regulation of cell proliferation
  • positive regulation of ERK1 and ERK2 cascade
  • platelet formation
  • cell adhesion
  • endomitotic cell cycle
  • thrombopoietin-mediated signaling pathway
  • positive regulation of male germ cell proliferation
  • positive regulation of cell growth
  • positive regulation of cell migration involved in sprouting angiogenesis
  • cellular response to DNA damage stimulus
  • positive regulation of cell-matrix adhesion
  • regulation of cell division
  • positive regulation of cell proliferation
  • negative regulation of neuron projection development
  • double-strand break repair
  • extrinsic apoptotic signaling pathway
  • cellular response to growth factor stimulus
  • cytoplasmic microtubule organization
  • positive regulation of protein phosphorylation
  • negative regulation of protein phosphorylation
  • negative regulation of microtubule depolymerization
  • positive regulation of protein targeting to membrane
  • regulation of cell proliferation
  • positive regulation of catalytic activity
  • angiogenesis
  • cell division
  • positive regulation of calcineurin-NFAT signaling cascade
  • cellular response to tumor necrosis factor
  • cellular response to nerve growth factor stimulus
  • response to ischemia
  • positive regulation of cell migration
  • negative regulation of megakaryocyte differentiation
  • spermatid development
Components
  • sarcolemma
  • cytoplasm
  • extracellular exosome
  • membrane
  • nucleoplasm
  • perinuclear region of cytoplasm
  • lamellipodium
  • dendrite
  • neuronal cell body
  • cell periphery
  • nucleus
  • ruffle membrane
  • endoplasmic reticulum
  • axon
  • neuron projection
  • plasma membrane
  • apical plasma membrane
  • filopodium tip
  • centrosome
  • vesicle
  • growth cone
  • Golgi apparatus
General FunctionCalcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
Specific FunctionCalcium ion binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ99828
UniProtKB Entry Name
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0049477|Calcium and integrin-binding protein 1 (CIB1)
ATGGGGGGCTCGGGCAGTCGCCTGTCCAAGGAGCTGCTGGCCGAGTACCAGGACTTGACG
TTCCTGACGAAGCAGGAGATCCTCCTAGCCCACAGGCGGTTTTGTGAGCTGCTTCCCCAG
GAGCAGCGGAGCGTGGAGTCGTCACTTCGGGCACAAGTGCCCTTCGAGCAGATTCTCAGC
CTTCCAGAGCTCAAGGCCAACCCCTTCAAGGAGCGAATCTGCAGGGTCTTCTCCACATCC
CCAGCCAAAGACAGCCTTAGCTTTGAGGACTTCCTGGATCTCCTCAGTGTGTTCAGTGAC
ACAGCCACGCCAGACATCAAGTCCCATTATGCCTTCCGCATCTTTGACTTTGATGATGAC
GGAACCTTGAACAGAGAAGACCTGAGCCGGCTGGTGAACTGCCTCACGGGAGAGGGCGAG
GACACACGGCTTAGTGCGTCTGAGATGAAGCAGCTCATCGACAACATCCTGGAGGAGTCT
GACATTGACAGGGATGGAACCATCAACCTCTCTGAGTTCCAGCACGTCATCTCCCGTTCT
CCAGACTTTGCCAGCTCCTTTAAGATTGTCCTGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location15
Locus15q26.1
References
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