Calsequestrin-1


NameCalsequestrin-1
Synonyms
  • Calmitine
  • Calsequestrin, skeletal muscle isoform
  • CASQ
Gene NameCASQ1
OrganismHomo sapiens
Amino acid sequence
>lcl|BSEQ0049492|Calsequestrin-1
MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNV
FKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKK
LGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI
KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV
TIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFL
ETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWME
MDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
Number of residuesNone
Molecular Weight45159.635
Theoretical pINone
GO Classification
Functions
  • calcium ion binding
Processes
  • protein polymerization
  • response to organic substance
  • skeletal muscle tissue development
  • regulation of cardiac conduction
  • sarcomere organization
  • ion transmembrane transport
  • response to denervation involved in regulation of muscle adaptation
  • regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
  • endoplasmic reticulum organization
  • response to heat
Components
  • terminal cisterna lumen
  • mitochondrion
  • smooth endoplasmic reticulum
  • endoplasmic reticulum
  • mitochondrial matrix
  • sarcoplasmic reticulum lumen
  • Golgi apparatus
  • sarcoplasmic reticulum membrane
  • T-tubule
  • I band
  • sarcoplasmic reticulum
General FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.
Specific FunctionCalcium ion binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP31415
UniProtKB Entry Name
Cellular LocationSarcoplasmic reticulum
Gene sequence
>lcl|BSEQ0049493|Calsequestrin-1 (CASQ1)
ATGAGTGCTACAGACAGGATGGGGCCCAGAGCTGTGCCGGGTCTGCGGCTGGCACTGCTG
TTGCTGCTGGTGCTAGGGACACCCAAGTCAGGGGTACAGGGGCAGGAAGGGCTGGACTTC
CCTGAGTACGATGGTGTGGACCGTGTGATCAATGTCAATGCAAAGAACTACAAGAATGTG
TTCAAGAAGTATGAGGTGCTGGCACTCCTCTACCATGAACCCCCCGAGGATGACAAGGCC
TCACAAAGACAATTTGAGATGGAGGAGCTGATCCTGGAGTTAGCAGCCCAAGTCCTAGAA
GACAAGGGTGTTGGCTTCGGGCTGGTAGACTCTGAGAAGGATGCAGCTGTGGCCAAGAAA
CTAGGCCTAACTGAAGTGGACAGCATGTATGTATTCAAGGGAGATGAAGTCATTGAGTAC
GATGGCGAGTTTTCTGCTGACACCATCGTGGAGTTTCTGCTTGATGTCCTAGAGGACCCT
GTGGAATTGATTGAAGGTGAACGAGAGCTGCAGGCGTTTGAGAATATTGAGGATGAGATC
AAACTCATTGGCTACTTCAAGAGCAAAGACTCAGAGCATTACAAAGCCTTCGAGGATGCA
GCTGAGGAGTTTCATCCCTACATCCCCTTCTTCGCCACCTTCGACAGCAAGGTGGCAAAG
AAGCTGACCCTGAAGCTGAATGAGATTGATTTCTACGAGGCCTTCATGGAAGAGCCTGTG
ACCATCCCAGACAAGCCCAATAGCGAAGAGGAGATTGTCAACTTCGTGGAGGAGCACAGG
AGATCAACCCTGAGGAAACTGAAGCCGGAGAGTATGTATGAGACCTGGGAGGATGATATG
GATGGAATCCACATTGTGGCCTTCGCAGAGGAAGCTGATCCTGATGGTTTCGAGTTCTTA
GAGACTCTCAAGGCTGTGGCCCAAGATAACACTGAAAACCCAGATCTTAGCATCATCTGG
ATTGACCCTGATGACTTCCCCCTGCTGGTCCCATACTGGGAGAAGACGTTTGACATCGAC
TTGTCAGCCCCACAAATAGGAGTCGTCAATGTTACTGATGCGGATAGCGTATGGATGGAA
ATGGACGATGAGGAGGACCTGCCTTCTGCTGAGGAGCTGGAGGACTGGCTGGAGGATGTC
CTGGAGGGCGAGATCAACACAGAGGACGATGACGATGATGATGATGACTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location1
Locus1q23.2
References
  1. Fujii J, Willard HF, MacLennan DH: Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene. Somat Cell Mol Genet. 1990 Mar;16(2):185-9. [2321095 ]
  2. Bataille N, Schmitt N, Aumercier-Maes P, Ollivier B, Lucas-Heron B, Lestienne P: Molecular cloning of human calmitine, a mitochondrial calcium binding protein, reveals identity with calsequestrine. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1477-82. [7945294 ]
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