Calreticulin-3


NameCalreticulin-3
Synonyms
  • Calreticulin-2
  • Calsperin
  • CRT2
Gene NameCALR3
OrganismHomo sapiens
Amino acid sequence
>lcl|BSEQ0049521|Calreticulin-3
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK
EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK
NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL
SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQ
SDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAI
GLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEE
EELLSGKINRHEHYFNQFHRRNEL
Number of residuesNone
Molecular Weight44995.345
Theoretical pINone
GO Classification
Functions
  • calcium ion binding
  • carbohydrate binding
  • unfolded protein binding
  • protein binding involved in protein folding
Processes
  • cell differentiation
  • spermatogenesis
Components
  • endoplasmic reticulum lumen
General FunctionDuring spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
Specific FunctionCalcium ion binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ96L12
UniProtKB Entry Name
Cellular LocationEndoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0049522|Calreticulin-3 (CALR3)
ATGGCCCGGGCTTTGGTCCAGCTCTGGGCCATATGCATGCTGCGAGTGGCGCTGGCTACC
GTCTATTTCCAAGAGGAATTTCTAGACGGAGAGCATTGGAGAAACCGATGGTTGCAGTCC
ACCAATGACTCCCGATTTGGGCATTTTAGACTTTCGTCGGGCAAGTTTTATGGTCATAAA
GAGAAAGATAAAGGTCTGCAAACCACTCAGAATGGCCGATTCTATGCCATCTCTGCACGC
TTCAAACCGTTCAGCAATAAAGGGAAAACTCTGGTTATTCAGTACACAGTAAAACATGAG
CAGAAGATGGACTGTGGAGGGGGCTACATTAAGGTCTTTCCTGCAGACATTGACCAGAAG
AACCTGAATGGAAAATCGCAGTACTATATTATGTTTGGACCCGATATTTGTGGATTTGAT
ATCAAGAAAGTTCATGTTATTTTACATTTCAAGAATAAGTATCACGAAAACAAGAAACTG
ATCAGGTGTAAGGTTGATGGCTTCACACACCTGTACACTCTAATTTTAAGACCAGATCTT
TCTTATGATGTGAAAATTGATGGTCAGTCAATTGAATCCGGCAGCATAGAGTACGACTGG
AACTTAACATCACTCAAGAAGGAAACGTCCCCGGCAGAATCGAAGGATTGGGAACAGACT
AAAGACAACAAAGCCCAGGACTGGGAGAAGCATTTTCTGGACGCCAGCACCAGCAAGCAG
AGCGACTGGAACGGTGACCTGGATGGGGACTGGCCAGCGCCGATGCTCCAGAAGCCCCCG
TACCAGGATGGCCTGAAACCAGAAGGTATTCATAAAGACGTCTGGCTCCACCGTAAGATG
AAGAATACCGACTATTTGACGCAGTATGACCTCTCAGAATTTGAGAACATTGGTGCCATT
GGCCTGGAGCTTTGGCAGGTGAGATCTGGAACCATTTTTGATAACTTTCTGATCACAGAT
GATGAAGAGTACGCAGATAATTTTGGCAAGGCCACCTGGGGCGAAACCAAGGGTCCAGAA
AGGGAGATGGATGCCATACAGGCCAAGGAGGAAATGAAGAAGGCCCGCGAGGAAGAGGAG
GAAGAGCTGCTGTCGGGAAAAATTAACAGGCACGAACATTACTTCAATCAATTTCACAGA
AGGAATGAACTTTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location19
Locus19p13.11
References
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  5. Persson S, Rosenquist M, Sommarin M: Identification of a novel calreticulin isoform (Crt2) in human and mouse. Gene. 2002 Sep 4;297(1-2):151-8. [12384296 ]
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