Macrophage receptor MARCO


NameMacrophage receptor MARCO
Synonyms
  • Macrophage receptor with collagenous structure
  • SCARA2
  • Scavenger receptor class A member 2
Gene NameMARCO
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049716|Macrophage receptor MARCO
MRNKKILKEDELLSETQQAAFHQIAMEPFEINVPKPKRRNGVNFSLAVVVIYLILLTAGA
GLLVVQVLNLQARLRVLEMYFLNDTLAAEDSPSFSLLQSAHPGEHLAQGASRLQVLQAQL
TWVRVSHEHLLQRVDNFTQNPGMFRIKGEQGAPGLQGHKGAMGMPGAPGPPGPPAEKGAK
GAMGRDGATGPSGPQGPPGVKGEAGLQGPQGAPGKQGATGTPGPQGEKGSKGDGGLIGPK
GETGTKGEKGDLGLPGSKGDRGMKGDAGVMGPPGAQGSKGDFGRPGPPGLAGFPGAKGDQ
GQPGLQGVPGPPGAVGHPGAKGEPGSAGSPGRAGLPGSPGSPGATGLKGSKGDTGLQGQQ
GRKGESGVPGPAGVKGEQGSPGLAGPKGAPGQAGQKGDQGVKGSSGEQGVKGEKGERGEN
SVSVRIVGSSNRGRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKGRALYKVGAGTGQ
IWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVECSV
Number of residuesNone
Molecular Weight52657.905
Theoretical pINone
GO Classification
Functions
  • scavenger receptor activity
  • transmembrane signaling receptor activity
  • signaling pattern recognition receptor activity
Processes
  • innate immune response
  • receptor-mediated endocytosis
  • cell surface receptor signaling pathway
  • apoptotic cell clearance
Components
  • plasma membrane
  • integral component of plasma membrane
  • endocytic vesicle membrane
  • collagen trimer
General FunctionPattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific FunctionScavenger receptor activity
Transmembrane Regions44-64
GenBank Protein ID
UniProtKB IDQ9UEW3
UniProtKB Entry Name
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0049717|Macrophage receptor MARCO (MARCO)
ATGAGAAATAAGAAAATTCTCAAGGAGGACGAGCTCTTGAGTGAGACCCAACAAGCTGCT
TTTCACCAAATTGCAATGGAGCCTTTCGAAATCAATGTTCCAAAGCCCAAGAGGAGAAAT
GGGGTGAACTTCTCCCTAGCTGTGGTGGTCATCTACCTGATCCTGCTCACCGCTGGCGCT
GGGCTGCTGGTGGTCCAAGTTCTGAATCTGCAGGCGCGGCTCCGGGTCCTGGAGATGTAT
TTCCTCAATGACACTCTGGCGGCTGAGGACAGCCCGTCCTTCTCCTTGCTGCAGTCAGCA
CACCCTGGAGAACACCTGGCTCAGGGTGCATCGAGGCTGCAAGTCCTGCAGGCCCAACTC
ACCTGGGTCCGCGTCAGCCATGAGCACTTGCTGCAGCGGGTAGACAACTTCACTCAGAAC
CCAGGGATGTTCAGAATCAAAGGTGAACAAGGCGCCCCAGGTCTTCAAGGTCACAAGGGG
GCCATGGGCATGCCTGGTGCCCCTGGCCCGCCGGGACCACCTGCTGAGAAGGGAGCCAAG
GGGGCTATGGGACGAGATGGAGCAACAGGCCCCTCGGGACCCCAAGGCCCACCGGGAGTC
AAGGGAGAGGCGGGCCTCCAAGGACCCCAGGGTGCTCCAGGGAAGCAAGGAGCCACTGGC
ACCCCAGGACCCCAAGGAGAGAAGGGCAGCAAAGGCGATGGGGGTCTCATTGGCCCAAAA
GGGGAAACTGGAACTAAGGGAGAGAAAGGAGACCTGGGTCTCCCAGGAAGCAAAGGGGAC
AGGGGCATGAAAGGAGATGCAGGGGTCATGGGGCCTCCTGGAGCCCAGGGGAGTAAAGGT
GACTTCGGGAGGCCAGGCCCACCAGGTTTGGCTGGTTTTCCTGGAGCTAAAGGAGATCAA
GGACAACCTGGACTGCAGGGTGTTCCGGGCCCTCCTGGTGCAGTGGGACACCCAGGTGCC
AAGGGTGAGCCTGGCAGTGCTGGCTCCCCTGGGCGAGCAGGACTTCCAGGGAGCCCCGGG
AGTCCAGGAGCCACAGGCCTGAAAGGAAGCAAAGGGGACACAGGACTTCAAGGACAGCAA
GGAAGAAAAGGAGAATCAGGAGTTCCAGGCCCTGCAGGTGTGAAGGGAGAACAGGGGAGC
CCAGGGCTGGCAGGTCCCAAGGGAGCCCCTGGACAAGCTGGCCAGAAGGGAGACCAGGGA
GTGAAAGGATCTTCTGGGGAGCAAGGAGTAAAGGGAGAAAAAGGTGAAAGAGGTGAAAAC
TCAGTGTCCGTCAGGATTGTCGGCAGTAGTAACCGAGGCCGGGCTGAAGTTTACTACAGT
GGTACCTGGGGGACAATTTGCGATGACGAGTGGCAAAATTCTGATGCCATTGTCTTCTGC
CGCATGCTGGGTTACTCCAAAGGAAGGGCCCTGTACAAAGTGGGAGCTGGCACTGGGCAG
ATCTGGCTGGATAATGTTCAGTGTCGGGGCACGGAGAGTACCCTGTGGAGCTGCACCAAG
AATAGCTGGGGCCATCATGACTGCAGCCACGAGGAGGACGCAGGCGTGGAGTGCAGCGTC
TGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location2
Locus2q14.2
References
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  2. Kangas M, Brannstrom A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K: Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. Genomics. 1999 May 15;58(1):82-9. [10331948 ]
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