Proteasome subunit alpha type-3

NameProteasome subunit alpha type-3
Synonyms
  • 3.4.25.1
  • HC8
  • Macropain subunit C8
  • Multicatalytic endopeptidase complex subunit C8
  • Proteasome component C8
  • PSC8
Gene NamePSMA3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007489|Proteasome subunit alpha type-3
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
Number of residuesNone
Molecular Weight28432.97
Theoretical pI4.97
GO Classification
Functions
  • endopeptidase activity
  • threonine-type endopeptidase activity
Processes
  • MAPK cascade
  • regulation of cellular amino acid metabolic process
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • negative regulation of apoptotic process
  • viral process
  • axon guidance
  • protein polyubiquitination
  • neurotrophin TRK receptor signaling pathway
  • epidermal growth factor receptor signaling pathway
  • regulation of mRNA stability
  • Ras protein signal transduction
  • programmed cell death
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • innate immune response
  • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • stimulatory C-type lectin receptor signaling pathway
  • small GTPase mediated signal transduction
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • Fc-epsilon receptor signaling pathway
  • tumor necrosis factor-mediated signaling pathway
  • vascular endothelial growth factor receptor signaling pathway
  • antigen processing and presentation of peptide antigen via MHC class I
  • cellular nitrogen compound metabolic process
  • positive regulation of canonical Wnt signaling pathway
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • gene expression
  • activation of MAPKK activity
  • polyamine metabolic process
  • negative regulation of canonical Wnt signaling pathway
  • regulation of apoptotic process
  • apoptotic process
  • proteasomal ubiquitin-independent protein catabolic process
  • mitotic cell cycle
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • small molecule metabolic process
  • fibroblast growth factor receptor signaling pathway
  • G1/S transition of mitotic cell cycle
  • NIK/NF-kappaB signaling
  • insulin receptor signaling pathway
  • T cell receptor signaling pathway
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Components
  • cytoplasm
  • nucleoplasm
  • nucleus
  • proteasome complex
  • proteasome core complex
  • proteasome core complex, alpha-subunit complex
  • cytosol
  • extracellular exosome
General FunctionThreonine-type endopeptidase activity
Specific FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP25788
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012729|Proteasome subunit alpha type-3 (PSMA3)
ATGAGCTCAATCGGCACTGGGTATGACCTGTCAGCCTCTACATTCTCTCCTGACGGAAGA
GTTTTTCAAGTTGAATATGCTATGAAGGCTGTGGAAAATAGTAGTACAGCTATTGGAATC
AGATGCAAAGATGGTGTTGTCTTTGGGGTAGAAAAATTAGTCCTTTCTAAACTTTATGAA
GAAGGTTCCAACAAAAGACTTTTTAATGTTGATCGGCATGTTGGAATGGCAGTAGCAGGT
TTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAAGCTTCCAACTTCAGA
TCTAACTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCCATGTATGTG
CATGCATATACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGGTCT
TACAGTGTGAATGACGGTGCGCAACTCTACATGATTGACCCATCAGGTGTTTCATACGGT
TATTGGGGCTGTGCCATCGGCAAAGCCAGGCAAGCTGCAAAGACGGAAATAGAGAAGCTT
CAGATGAAAGAAATGACCTGCCGTGATATCGTTAAAGAAGTTGCAAAAATAATTTACATA
GTACATGACGAAGTTAAGGATAAAGCTTTTGAACTAGAACTCAGCTGGGTTGGTGAATTA
ACTAATGGAAGACATGAAATTGTTCCAAAAGATATAAGAGAAGAAGCAGAGAAATATGCT
AAGGAATCTCTGAAGGAAGAAGATGAATCAGATGATGATAATATGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location14
Locus14q23
References
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