26S protease regulatory subunit 6A

Name26S protease regulatory subunit 6A
Synonyms
  • 26S proteasome AAA-ATPase subunit RPT5
  • Proteasome 26S subunit ATPase 3
  • Proteasome subunit P50
  • Tat-binding protein 1
  • TBP-1
  • TBP1
Gene NamePSMC3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049777|26S protease regulatory subunit 6A
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
MEGILEVQAKKKANLQYYA
Number of residuesNone
Molecular Weight49203.11
Theoretical pINone
GO Classification
Functions
  • ATP binding
  • TBP-class protein binding
  • ATPase activity
  • proteasome-activating ATPase activity
  • identical protein binding
Processes
  • negative regulation of canonical Wnt signaling pathway
  • blastocyst development
  • MAPK cascade
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • protein deubiquitination
  • positive regulation of transcription from RNA polymerase II promoter
  • NIK/NF-kappaB signaling
  • stimulatory C-type lectin receptor signaling pathway
  • modulation by host of viral transcription
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  • T cell receptor signaling pathway
  • ubiquitin-dependent ERAD pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
  • regulation of cellular amino acid metabolic process
  • protein polyubiquitination
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • viral process
  • regulation of mRNA stability
  • tumor necrosis factor-mediated signaling pathway
  • Fc-epsilon receptor signaling pathway
  • anaphase-promoting complex-dependent catabolic process
  • transmembrane transport
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • negative regulation of G2/M transition of mitotic cell cycle
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • neutrophil degranulation
  • positive regulation of canonical Wnt signaling pathway
  • Wnt signaling pathway, planar cell polarity pathway
Components
  • membrane
  • ficolin-1-rich granule lumen
  • P-body
  • extracellular region
  • nucleus
  • cytosolic proteasome complex
  • cytosol
  • nuclear proteasome complex
  • nucleoplasm
  • proteasome accessory complex
  • proteasome complex
  • secretory granule lumen
  • proteasome regulatory particle, base subcomplex
General FunctionComponent of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Specific FunctionAtp binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP17980
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0049778|26S protease regulatory subunit 6A (PSMC3)
ATGAATCTGCTGCCGAATATTGAGAGTCCAGTGACTCGGCAGGAGAAGATGGCGACCGTG
TGGGATGAGGCCGAGCAAGATGGAATTGGGGAGGAGGTGCTCAAGATGTCCACGGAGGAG
ATCATCCAGCGCACACGGCTGCTGGACAGTGAGATCAAGATCATGAAGAGTGAAGTGTTG
AGAGTCACCCATGAGCTCCAAGCCATGAAGGACAAGATAAAAGAGAACAGTGAGAAAATC
AAAGTGAACAAGACCCTGCCGTACCTTGTCTCCAACGTCATCGAGCTCCTGGATGTTGAT
CCTAATGACCAAGAGGAGGATGGTGCCAATATTGACCTGGACTCCCAGAGGAAGGGCAAG
TGTGCTGTGATCAAAACCTCTACACGACAGACGTACTTCCTTCCTGTGATTGGGTTGGTG
GATGCTGAAAAGCTAAAGCCAGGAGACCTGGTGGGTGTGAACAAAGACTCCTATCTGATC
CTGGAGACGCTGCCCACAGAGTATGACTCGCGGGTGAAGGCCATGGAGGTAGACGAGAGG
CCCACGGAGCAATACAGTGACATTGGGGGTTTGGACAAGCAGATCCAGGAGCTGGTGGAG
GCCATTGTCTTGCCAATGAACCACAAGGAGAAGTTTGAGAACTTGGGGATCCAACCTCCA
AAAGGGGTGCTGATGTATGGGCCCCCAGGGACGGGGAAGACCCTCCTGGCCCGGGCCTGT
GCCGCACAGACTAAGGCCACCTTCCTAAAGCTGGCTGGCCCCCAGCTGGTGCAGATGTTC
ATTGGAGATGGTGCCAAGCTAGTCCGGGATGCCTTTGCCCTGGCCAAGGAGAAAGCGCCC
TCTATCATCTTCATTGATGAGTTGGATGCCATCGGCACCAAGCGCTTTGACAGTGAGAAG
GCTGGGGACCGGGAGGTGCAGAGGACAATGCTGGAGCTTCTGAACCAGCTGGATGGCTTC
CAGCCCAACACCCAAGTTAAGGTAATTGCAGCCACAAACAGGGTGGACATCCTGGACCCC
GCCCTCCTCCGCTCGGGCCGCCTTGACCGCAAGATAGAGTTCCCGATGCCCAATGAGGAG
GCCCGGGCCAGAATCATGCAGATCCACTCCCGAAAGATGAATGTCAGTCCTGACGTGAAC
TACGAGGAGCTGGCCCGCTGCACAGATGACTTCAATGGGGCCCAGTGCAAGGCTGTGTGT
GTGGAGGCGGGCATGATCGCACTGCGCAGGGGTGCCACGGAGCTCACCCACGAGGACTAC
ATGGAAGGCATCCTGGAGGTGCAGGCCAAGAAGAAAGCCAACCTACAATACTACGCCTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location11
Locus11p11.2
References
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