Tropomyosin alpha-4 chain


NameTropomyosin alpha-4 chain
Synonyms
  • TM30p1
  • Tropomyosin-4
Gene NameTPM4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049791|Tropomyosin alpha-4 chain
MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE
EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE
KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ
TLNELNCI
Number of residuesNone
Molecular Weight28521.535
Theoretical pINone
GO Classification
Functions
  • calcium ion binding
  • actin filament binding
  • structural constituent of muscle
Processes
  • actin filament organization
  • muscle filament sliding
  • osteoblast differentiation
  • movement of cell or subcellular component
  • muscle contraction
Components
  • membrane
  • podosome
  • cytoskeleton
  • actin filament
  • cytosol
  • extracellular exosome
  • filamentous actin
  • stress fiber
  • muscle thin filament tropomyosin
  • focal adhesion
  • cortical cytoskeleton
General FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
Specific FunctionActin filament binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP67936
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0049792|Tropomyosin alpha-4 chain (TPM4)
ATGGCCGGCCTCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAG
GCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCGAGCGCGAG
CGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAG
GAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCA
GAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAG
GATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAA
GAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTG
GAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAA
CTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAA
AAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAG
ACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTG
GAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAG
ACACTAAACGAACTTAACTGTATATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location19
Locus19p13.12-p13.11
References
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From www.t3db.ca