14-3-3 protein theta

Name14-3-3 protein theta
Synonyms
  • 14-3-3 protein T-cell
  • 14-3-3 protein tau
  • Protein HS1
Gene NameYWHAQ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049797|14-3-3 protein theta
MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWR
VISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLK
MKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYE
ILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAA
EGAEN
Number of residuesNone
Molecular Weight27763.93
Theoretical pINone
GO Classification
Functions
  • ion channel binding
  • protein domain specific binding
  • protein N-terminus binding
  • 14-3-3 protein binding
  • protein C-terminus binding
Processes
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • small GTPase mediated signal transduction
  • negative regulation of transcription, DNA-templated
  • substantia nigra development
  • protein targeting
  • negative regulation of ion transmembrane transport
  • membrane organization
Components
  • cytoplasm
  • mitochondrion
  • focal adhesion
  • membrane
  • protein complex
  • cytoplasmic vesicle membrane
  • cytosol
  • extracellular exosome
General FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Specific Function14-3-3 protein binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP27348
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0049798|14-3-3 protein theta (YWHAQ)
ATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGAC
GACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAG
CGCAACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGG
GTCATCTCTAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAG
GACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCACGGTGCTGGAATTG
TTGGATAAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAA
ATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCGTGTGGTGATGATCGAAAACAA
ACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATG
CAACCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTATGAG
ATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATT
GCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTG
CTTAGAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCA
GAAGGGGCTGAAAACTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location2
Locus2p25.1
References
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From www.t3db.ca