Fumarate reductase flavoprotein subunit

Name	Fumarate reductase flavoprotein subunit
Synonyms	1.3.5.4 FL cyt Flavocytochrome c
Gene Name	None
Organism	Shewanella oneidensis (strain MR-1)
Amino acid sequence	>lcl\|BSEQ0016447\|Fumarate reductase flavoprotein subunit MFTRKIQKTALAMLISGAMAGTAYAAPEVLADFHGEMGGCDSCHVSDKGGVTNDNLTHEN GQCVSCHGDLKELAAAAPKDKVSPHKSHLIGEIACTSCHKGHEKSVAYCDACHSFGFDMP FGGKWERKFVPVDADKAAQDKAIAAGVKETTDVVIIGSGGAGLAAAVSARDAGAKVILLE KEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKVLANNS SDSIDWLTSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDNAVKRGTDIRLNS RVVRILEDASGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKAT NHPGATGDGLDVALQAGAATRDLEYIQAHPTYSPAGGVMITEAVRGNGAIVVNREGNRFM NEITTRDKASAAILQQKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDV PAAELAKTVTAYNGFVKSGKDAQFERPDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKA EVKSEKTGKPITGLYAAGEVTGGVHGANRLGGNAISDIVTYGRIAGASAAKFAKDN
Number of residues	None
Molecular Weight	62447.475
Theoretical pI	7.64
GO Classification	Functions metal ion binding succinate dehydrogenase activity Processes Components periplasmic space
General Function	Succinate dehydrogenase activity
Specific Function	Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P83223
UniProtKB Entry Name
Cellular Location	Periplasm
Gene sequence	>lcl\|BSEQ0016448\|Fumarate reductase flavoprotein subunit ATGTTCACAAGAAAGATTCAAAAAACAGCACTAGCCATGCTGATCTCTGGCGCAATGGCA GGCACAGCCTATGCCGCTCCAGAAGTACTAGCCGATTTTCACGGTGAAATGGGTGGCTGC GATAGCTGCCACGTATCAGACAAAGGTGGCGTGACTAACGACAACCTGACCCATGAGAAT GGCCAATGTGTTAGCTGCCACGGTGACTTAAAAGAACTGGCTGCAGCAGCGCCTAAAGAT AAAGTTTCTCCGCACAAATCTCACTTAATTGGTGAAATCGCTTGTACGAGCTGCCACAAA GGCCACGAAAAATCAGTAGCTTATTGTGATGCTTGCCATAGCTTCGGCTTCGATATGCCA TTTGGTGGCAAGTGGGAACGTAAGTTTGTACCTGTTGATGCAGACAAAGCAGCACAAGAT AAAGCCATTGCTGCTGGTGTGAAAGAAACCACAGACGTTGTAATTATCGGCTCTGGTGGT GCTGGTCTTGCCGCTGCCGTATCTGCCCGTGATGCTGGCGCGAAAGTGATTCTGTTAGAA AAAGAACCTATCCCAGGTGGTAACACTAAACTGGCTGCCGGTGGTATGAACGCCGCAGAA ACTAAGCCACAGGCTAAGTTAGGTATCGAAGATAAGAAACAAATCATGATCGACGACACT ATGAAAGGTGGCCGCAACATCAACGATCCTGAATTAGTTAAAGTACTGGCTAACAACTCT TCAGACTCAATCGATTGGTTAACCTCTATGGGTGCCGACATGACTGACGTGGGTCGTATG GGTGGCGCGAGCGTTAACCGTAGTCACCGTCCAACCGGTGGTGCAGGTGTTGGTGCTCAC GTAGCACAAGTGCTGTGGGACAACGCCGTTAAGCGTGGTACTGATATTCGCTTAAACAGC CGCGTTGTGCGCATCCTTGAAGATGCAAGCGGTAAAGTGACCGGCGTTTTAGTGAAAGGT GAATACACAGGTTACTATGTGATCAAAGCCGATGCAGTAGTCATTGCAGCAGGTGGTTTT GCGAAAAACAACGAACGTGTTTCTAAATACGATCCTAAGTTAAAAGGCTTTAAAGCGACC AACCACCCAGGTGCGACGGGTGACGGCTTAGACGTAGCTCTACAAGCGGGCGCAGCAACA CGTGACTTAGAATACATCCAAGCTCACCCAACTTACTCTCCAGCGGGTGGCGTGATGATC ACCGAGGCAGTACGTGGTAACGGTGCAATCGTGGTGAACCGTGAAGGTAATCGTTTTATG AACGAAATCACCACCCGTGATAAAGCGTCTGCGGCGATTCTGCAACAAAAAGGTGAAAGC GCTTACCTAGTATTCGATGACTCTATCCGTAAGAGCTTGAAGGCCATCGAAGGTTATGTT CACCTGAACATTGTAAAAGAAGGTAAAACCATCGAAGAGTTAGCGAAACAAATCGATGTA CCTGCAGCTGAATTGGCAAAAACAGTAACAGCCTACAACGGTTTCGTTAAATCAGGTAAA GATGCTCAATTTGAACGTCCTGATTTACCACGTGAATTAGTGGTAGCTCCTTTCTACGCC TTAGAAATTGCACCAGCGGTTCACCACACTATGGGTGGTCTGGTGATTGATACTAAAGCC GAAGTGAAGAGTGAGAAAACCGGTAAACCTATCACTGGTTTATACGCTGCAGGCGAAGTG ACTGGTGGTGTTCACGGTGCTAACCGTTTAGGTGGTAACGCTATCTCTGATATCGTCACC TACGGCCGTATCGCGGGTGCATCTGCCGCTAAATTCGCTAAAGATAATTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Tsapin AI, Vandenberghe I, Nealson KH, Scott JH, Meyer TE, Cusanovich MA, Harada E, Kaizu T, Akutsu H, Leys D, Van Beeumen JJ: Identification of a small tetraheme cytochrome c and a flavocytochrome c as two of the principal soluble cytochromes c in Shewanella oneidensis strain MR1. Appl Environ Microbiol. 2001 Jul;67(7):3236-44. [11425747 ] Heidelberg JF, Paulsen IT, Nelson KE, Gaidos EJ, Nelson WC, Read TD, Eisen JA, Seshadri R, Ward N, Methe B, Clayton RA, Meyer T, Tsapin A, Scott J, Beanan M, Brinkac L, Daugherty S, DeBoy RT, Dodson RJ, Durkin AS, Haft DH, Kolonay JF, Madupu R, Peterson JD, Umayam LA, White O, Wolf AM, Vamathevan J, Weidman J, Impraim M, Lee K, Berry K, Lee C, Mueller J, Khouri H, Gill J, Utterback TR, McDonald LA, Feldblyum TV, Smith HO, Venter JC, Nealson KH, Fraser CM: Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol. 2002 Nov;20(11):1118-23. Epub 2002 Oct 7. [12368813 ] Leys D, Tsapin AS, Nealson KH, Meyer TE, Cusanovich MA, Van Beeumen JJ: Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1. Nat Struct Biol. 1999 Dec;6(12):1113-7. [10581551 ]

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