Inter-alpha-trypsin inhibitor heavy chain H1

NameInter-alpha-trypsin inhibitor heavy chain H1
Synonyms
  • IGHEP1
  • Inter-alpha-trypsin inhibitor complex component III
  • ITI heavy chain H1
  • Serum-derived hyaluronan-associated protein
  • SHAP
Gene NameITIH1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049870|Inter-alpha-trypsin inhibitor heavy chain H1
MDGAMGPRGLLLCMYLVSLLILQAMPALGSATGRSKSSEKRQAVDTAVDGVFIRSLKVNC
KVTSRFAHYVVTSQVVNTANEAREVAFDLEIPKTAFISDFAVTADGNAFIGDIKDKVTAW
KQYRKAAISGENAGLVRASGRTMEQFTIHLTVNPQSKVTFQLTYEEVLKRNHMQYEIVIK
VKPKQLVHHFEIDVDIFEPQGISKLDAQASFLPKELAAQTIKKSFSGKKGHVLFRPTVSQ
QQSCPTCSTSLLNGHFKVTYDVSRDKICDLLVANNHFAHFFAPQNLTNMNKNVVFVIDIS
GSMRGQKVKQTKEALLKILGDMQPGDYFDLVLFGTRVQSWKGSLVQASEANLQAAQDFVR
GFSLDEATNLNGGLLRGIEILNQVQESLPELSNHASILIMLTDGDPTEGVTDRSQILKNV
RNAIRGRFPLYNLGFGHNVDFNFLEVMSMENNGRAQRIYEDHDATQQLQGFYSQVAKPLL
VDVDLQYPQDAVLALTQNHHKQYYEGSEIVVAGRIADNKQSSFKADVQAHGEGQEFSITC
LVDEEEMKKLLRERGHMLENHVERLWAYLTIQELLAKRMKVDREERANLSSQALQMSLDY
GFVTPLTSMSIRGMADQDGLKPTIDKPSEDSPPLEMLGPRRTFVLSALQPSPTHSSSNTQ
RLPDRVTGVDTDPHFIIHVPQKEDTLCFNINEEPGVILSLVQDPNTGFSVNGQLIGNKAR
SPGQHDGTYFGRLGIANPATDFQLEVTPQNITLNPGFGGPVFSWRDQAVLRQDGVVVTIN
KKRNLVVSVDDGGTFEVVLHRVWKGSSVHQDFLGFYVLDSHRMSARTHGLLGQFFHPIGF
EVSDIHPGSDPTKPDATMVVRNRRLTVTRGLQKDYSKDPWHGAEVSCWFIHNNGAGLIDG
AYTDYIVPDIF
Number of residuesNone
Molecular Weight101388.49
Theoretical pINone
GO Classification
Functions
  • calcium ion binding
  • serine-type endopeptidase inhibitor activity
Processes
  • hyaluronan metabolic process
Components
  • extracellular region
  • extracellular exosome
  • blood microparticle
General FunctionMay act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Specific FunctionCalcium ion binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP19827
UniProtKB Entry Name
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0049871|Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)
ATGGACGGTGCCATGGGGCCTCGGGGGCTGCTGTTGTGCATGTACCTGGTATCTCTCCTC
ATCCTGCAGGCCATGCCTGCCCTGGGCTCGGCTACAGGCAGGTCCAAGAGCAGCGAGAAG
CGACAGGCTGTGGACACCGCTGTCGATGGCGTGTTCATCCGGAGTTTGAAAGTCAACTGC
AAAGTCACCTCTCGCTTCGCCCACTATGTTGTCACCAGCCAAGTGGTCAACACTGCCAAT
GAAGCCAGGGAAGTGGCCTTCGACCTGGAAATCCCCAAGACAGCATTCATCAGTGACTTT
GCCGTTACAGCAGATGGAAACGCATTTATCGGAGACATAAAGGACAAGGTGACTGCATGG
AAGCAGTACCGGAAAGCAGCTATCTCAGGAGAGAATGCCGGCCTTGTCAGGGCCTCGGGG
AGAACTATGGAGCAATTCACCATCCACCTCACCGTCAATCCCCAGAGCAAGGTCACGTTT
CAGCTGACTTATGAGGAAGTGCTGAAGAGAAACCATATGCAGTATGAAATTGTCATCAAA
GTCAAGCCCAAGCAGCTGGTGCATCATTTTGAGATTGATGTGGACATCTTCGAGCCCCAG
GGGATCAGCAAGCTGGATGCCCAGGCCTCTTTCCTGCCGAAGGAACTGGCAGCCCAAACT
ATCAAGAAGTCCTTCTCAGGAAAAAAGGGTCATGTGCTGTTCCGTCCCACCGTGAGCCAG
CAGCAGTCCTGCCCCACATGCTCTACATCCTTACTGAACGGGCACTTCAAGGTGACCTAC
GATGTCAGTCGAGACAAGATCTGCGACCTCCTGGTGGCCAATAACCACTTTGCCCACTTC
TTTGCCCCCCAAAACCTGACAAACATGAACAAGAACGTGGTTTTTGTGATTGACATCAGT
GGCTCCATGAGAGGCCAGAAAGTGAAGCAGACCAAGGAGGCACTCCTTAAAATTCTGGGG
GACATGCAGCCAGGGGACTACTTTGACCTGGTTCTTTTTGGGACTCGAGTACAATCGTGG
AAGGGCTCGCTGGTGCAAGCATCTGAGGCCAACCTACAAGCAGCTCAAGACTTTGTGCGG
GGCTTTTCCCTGGATGAGGCCACAAACCTGAATGGAGGTTTGCTCCGGGGAATTGAGATC
TTGAACCAAGTTCAGGAAAGCCTCCCAGAACTCAGCAACCATGCCTCAATACTCATCATG
TTGACAGATGGCGATCCCACAGAGGGGGTGACGGACCGTTCCCAAATCCTCAAGAACGTC
CGCAACGCCATCCGGGGCAGGTTCCCGCTCTACAACCTGGGTTTCGGCCACAATGTGGAC
TTTAACTTTCTGGAGGTCATGTCCATGGAGAACAACGGACGGGCCCAGAGAATCTACGAG
GACCATGATGCCACCCAGCAGCTGCAGGGTTTCTACAGCCAGGTAGCCAAACCCCTGCTG
GTGGATGTGGATTTGCAGTACCCCCAGGATGCTGTCTTGGCCCTGACCCAGAACCACCAT
AAACAGTACTACGAAGGCTCAGAGATTGTGGTGGCCGGGCGCATTGCTGACAACAAACAG
AGCAGCTTCAAGGCTGATGTGCAGGCCCATGGGGAGGGACAAGAATTCAGTATAACCTGC
CTAGTGGATGAGGAGGAGATGAAGAAACTGCTCCGAGAGCGTGGCCACATGCTGGAGAAC
CACGTCGAGCGCCTCTGGGCCTACCTCACCATCCAGGAGCTGCTGGCCAAGCGGATGAAG
GTGGACAGGGAGGAGAGGGCCAACCTGTCATCCCAGGCCCTGCAGATGTCGCTGGACTAT
GGGTTTGTGACCCCACTGACCTCCATGAGCATCAGGGGCATGGCGGACCAGGACGGCCTG
AAGCCCACCATCGACAAGCCCTCAGAGGATTCTCCGCCTTTGGAGATGCTGGGACCCAGA
AGGACGTTCGTGCTGTCAGCCTTGCAGCCTTCTCCTACTCATTCCAGCTCCAATACCCAG
CGGCTGCCAGACCGAGTGACCGGCGTGGACACAGACCCTCACTTCATCATCCACGTGCCC
CAGAAAGAGGACACCCTGTGCTTCAACATCAATGAGGAGCCTGGTGTTATCCTGAGCCTG
GTACAGGACCCCAACACAGGCTTCTCAGTGAATGGACAGCTCATTGGCAACAAGGCCAGG
AGCCCTGGGCAGCATGACGGCACGTACTTCGGGCGGCTGGGAATCGCAAACCCTGCCACG
GACTTTCAGTTGGAAGTGACTCCTCAGAACATTACGCTGAACCCCGGCTTTGGTGGGCCT
GTGTTTTCCTGGAGGGACCAAGCTGTGCTGCGGCAGGACGGGGTGGTGGTGACCATCAAC
AAGAAGAGGAACCTGGTGGTGTCTGTGGACGACGGTGGCACCTTTGAGGTTGTTTTGCAC
CGAGTGTGGAAGGGGAGCTCGGTCCACCAGGACTTCCTGGGCTTCTATGTGCTGGACAGT
CATCGGATGTCAGCCCGGACGCACGGGCTGCTGGGGCAATTTTTCCACCCCATCGGTTTT
GAAGTGTCTGACATCCACCCAGGCTCTGACCCCACAAAGCCAGATGCCACGATGGTGGTG
AGGAACCGCCGGCTCACGGTCACCAGGGGTTTGCAAAAAGACTACAGCAAGGACCCGTGG
CATGGGGCCGAGGTGTCCTGCTGGTTCATTCACAACAATGGGGCTGGACTCATCGATGGT
GCCTACACTGATTATATCGTCCCCGACATCTTCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location3
Locus3p21.1
References
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