Junction plakoglobin

NameJunction plakoglobin
Synonyms
  • Catenin gamma
  • CTNNG
  • Desmoplakin III
  • Desmoplakin-3
  • DP3
Gene NameJUP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049878|Junction plakoglobin
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT
YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS
QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE
SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH
LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC
NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY
GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR
HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY
RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM
DGDYPIDTYSDGLRPPYPTADHMLA
Number of residuesNone
Molecular Weight81743.98
Theoretical pINone
GO Classification
Functions
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
  • signal transducer activity
  • protein homodimerization activity
  • structural molecule activity
  • protein phosphatase binding
  • structural constituent of cell wall
  • alpha-catenin binding
  • cadherin binding
  • protein kinase binding
  • cell adhesion molecule binding
  • transcription coactivator activity
Processes
  • bundle of His cell-Purkinje myocyte adhesion involved in cell communication
  • protein heterooligomerization
  • neutrophil degranulation
  • regulation of ventricular cardiac muscle cell action potential
  • cell migration
  • regulation of cell proliferation
  • endothelial cell-cell adhesion
  • positive regulation of canonical Wnt signaling pathway
  • cellular response to indole-3-methanol
  • cytoskeletal anchoring at plasma membrane
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • desmosome assembly
  • establishment of protein localization to plasma membrane
  • detection of mechanical stimulus
  • single organismal cell-cell adhesion
  • adherens junction organization
  • keratinization
  • regulation of heart rate by cardiac conduction
  • cornification
  • adherens junction assembly
  • positive regulation of protein import into nucleus
Components
  • focal adhesion
  • specific granule lumen
  • cytoplasm
  • catenin complex
  • extracellular exosome
  • intermediate filament
  • apicolateral plasma membrane
  • fascia adherens
  • cell-cell junction
  • gamma-catenin-TCF7L2 complex
  • protein-DNA complex
  • extracellular matrix
  • zonula adherens
  • desmosome
  • cytoskeleton
  • cornified envelope
  • extracellular region
  • nucleus
  • intercalated disc
  • cytoplasmic side of plasma membrane
  • plasma membrane
  • lateral plasma membrane
  • actin cytoskeleton
  • Z disc
  • ficolin-1-rich granule lumen
  • cell-cell adherens junction
  • cytosol
General FunctionCommon junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Specific FunctionAlpha-catenin binding
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP14923
UniProtKB Entry Name
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0049879|Junction plakoglobin (JUP)
ATGGAGGTGATGAACCTGATGGAGCAGCCTATCAAGGTGACTGAGTGGCAGCAGACATAC
ACCTACGACTCGGGTATCCACTCGGGCGCCAACACCTGCGTGCCCTCCGTCAGCAGCAAG
GGCATCATGGAGGAGGATGAGGCCTGCGGGCGCCAGTACACGCTCAAGAAAACCACCACT
TACACCCAGGGGGTGCCCCCCAGCCAAGGTGATCTGGAGTACCAGATGTCCACAACAGCC
AGGGCCAAACGGGTGCGGGAGGCCATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTT
CTGCTGGCCACCCAGGTGGAGGGGCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCC
CAGCTGCTCAAGTCGGCCATTGTGCATCTCATCAACTACCAGGACGATGCCGAGCTGGCC
ACTCGCGCCCTGCCCGAGCTCACCAAACTGCTCAACGACGAGGACCCGGTGGTGGTGACC
AAGGCGGCCATGATTGTGAACCAGCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATG
GGCTCGCCCCAGCTGGTGGCCGCTGTCGTGCGTACCATGCAGAATACCAGCGACCTGGAC
ACAGCCCGCTGCACCACCAGCATCCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTC
GCCATCTTCAAGTCGGGTGGCATCCCTGCTCTGGTCCGCATGCTCAGCTCCCCTGTGGAG
TCGGTCCTGTTCTATGCCATCACCACGCTGCACAACCTGCTCCTGTACCAGGAGGGCGCC
AAGATGGCCGTGCGCCTGGCCGACGGGCTGCAAAAGATGGTGCCCCTGCTCAACAAGAAC
AACCCCAAGTTCCTGGCCATCACCACCGACTGCCTGCAGCTCCTGGCCTACGGCAACCAG
GAGAGCAAGCTGATCATCCTGGCCAATGGTGGGCCCCAGGCCCTCGTGCAGATCATGCGT
AACTACAGTTATGAAAAGCTGCTCTGGACCACCAGTCGTGTGCTCAAGGTGCTATCCGTG
TGTCCCAGCAATAAGCCTGCCATTGTGGAGGCTGGTGGGATGCAGGCCCTGGGCAAGCAC
CTGACCAGCAACAGCCCCCGCCTGGTGCAGAACTGCCTGTGGACCCTGCGCAACCTCTCA
GATGTGGCCACCAAGCAGGAGGGCCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTG
AGTGTGGATGACGTCAACGTCCTCACCTGTGCCACGGGCACACTCTCCAACCTGACATGC
AACAACAGCAAGAACAAGACGCTGGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCAT
GCCATCCTGCGTGCTGGTGACAAGGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGC
CACCTCACTAGCCGCCACCCTGAGGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTAT
GGCATCCCAGCCATCGTGAAGCTGCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGCA
ACCATCGGCTTGATCAGGAATCTGGCCCTGTGCCCAGCCAACCATGCCCCGCTGCAGGAG
GCAGCGGTCATCCCCCGCCTCGTCCAACTGCTGGTGAAGGCCCACCAGGATGCCCAGCGC
CACGTAGCTGCAGGCACACAGCAGCCCTACACGGATGGTGTGAGGATGGAGGAGATTGTG
GAGGGCTGCACCGGAGCACTGCACATCCTCGCCCGGGACCCCATGAACCGCATGGAGATC
TTCCGGCTCAACACCATTCCCCTGTTTGTGCAGCTCCTGTACTCGTCGGTGGAGAACATC
CAGCGCGTGGCTGCCGGGGTGCTGTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCC
ATTGATGCAGAGGGGGCCTCGGCCCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGC
ACTGCCACCTACGCTGCTGCCGTCCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTAC
CGGAAGCGCGTGTCCGTGGAGCTCACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGG
GAGGCTGCCCAGAGCATGATTCCCATCAATGAGCCCTATGGAGATGACATGGATGCCACC
TACCGCCCCATGTACTCCAGCGATGTGCCCCTTGACCCGCTGGAGATGCACATGGACATG
GATGGAGACTACCCCATCGACACCTACAGCGACGGCCTCAGGCCCCCGTACCCCACTGCA
GACCACATGCTGGCCTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location17
Locus17q21.2
References
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