N-acylamino acid racemase

Name	N-acylamino acid racemase
Synonyms	4-(2'-carboxyphenyl)-4-oxybutyric acid synthase 4.2.1.113 menC o-succinylbenzoic acid synthase OSB synthase
Gene Name	Aaar
Organism	Amycolatopsis sp.
Amino acid sequence	>lcl\|BSEQ0011781\|o-succinylbenzoate synthase MKLSGVELRRVQMPLVAPFRTSFGTQSVRELLLLRAVTPAGEGWGECVTMAGPLYSSEYN DGAEHVLRHYLIPALLAAEDITAAKVTPLLAKFKGHRMAKGALEMAVLDAELRAHERSFA AELGSVRDSVPCGVSVGIMDTIPQLLDVVGGYLDEGYVRIKLKIEPGWDVEPVRAVRERF GDDVLLQVDANTAYTLGDAPQLARLDPFGLLLIEQPLEEEDVLGHAELARRIQTPICLDE SIVSARAAADAIKLGAVQIVNIKPGRVGGYLEARRVHDVCAAHGIPVWCGGMIETGLGRA ANVALASLPNFTLPGDTSASDRFYKTDITEPFVLSGGHLPVPTGPGLGVAPIPELLDEVT TAKVWIGS
Number of residues	None
Molecular Weight	39406.005
Theoretical pI	4.93
GO Classification	Functions hydro-lyase activity magnesium ion binding Processes menaquinone biosynthetic process Components
General Function	None
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q44244
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0004897\|1107 bp GTGAAACTCAGCGGTGTGGAACTGCGCCGGGTGCAGATGCCGCTCGTCGCCCCGTTCCGG ACTTCGTTCGGCACCCAGTCGGTCCGCGAGCTCTTGCTGCTGCGCGCGGTCACGCCGGCC GGCGAGGGCTGGGGCGAATGCGTGACGATGGCCGGTCCGCTGTACTCGTCGGAGTACAAC GACGGCGCGGAACACGTGCTGCGGCACTACTTGATCCCGGCGCTGCTGGCCGCGGAAGAC ATCACCGCGGCGAAGGTGACGCCGCTGCTGGCCAAGTTCAAGGGCCACCGGATGGCCAAG GGCGCGCTGGAGATGGCCGTGCTCGACGCCGAACTCCGCGCGCACGAGAGGTCGTTCGCC GCCGAACTCGGATCGGTGCGCGATTCTGTGCCGTGCGGCGTTTCGGTCGGGATCATGGAC ACCATCCCGCAACTGCTCGACGTCGTGGGCGGATACCTCGACGAGGGTTACGTGCGGATC AAGCTGAAGATCGAACCCGGCTGGGACGTCGAGCCGGTGCGCGCGGTCCGCGAGCGCTTC GGCGACGACGTGCTGCTGCAGGTCGACGCGAACACCGCCTACACCCTCGGCGACGCGCCG CAGCTGGCCCGGCTCGACCCGTTCGGCCTGCTGCTGATCGAGCAGCCGCTGGAAGAGGAG GACGTGCTCGGCCACGCCGAACTGGCCCGCCGGATCCAGACACCGATCTGCCTCGACGAG TCGATCGTGTCGGCGCGCGCGGCGGCGGACGCCATCAAGCTGGGCGCGGTCCAAATCGTG AACATCAAACCGGGCCGCGTCGGCGGGTACCTGGAAGCGCGGCGGGTGCACGACGTGTGC GCGGCGCACGGGATCCCGGTGTGGTGCGGCGGGATGATCGAGACCGGCCTCGGCCGGGCG GCGAACGTCGCGCTGGCCTCGCTGCCGAACTTCACCCTGCCCGGCGACACCTCGGCGTCG GACCGGTTCTACAAAACCGACATCACCGAGCCGTTCGTGCTCTCCGGCGGCCACCTCCCG GTGCCGACCGGACCGGGCCTCGGCGTGGCGCCGATTCCGGAGCTGCTGGACGAGGTGACC ACGGCAAAGGTGTGGATCGGTTCGTAG
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Thoden JB, Taylor Ringia EA, Garrett JB, Gerlt JA, Holden HM, Rayment I: Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. Biochemistry. 2004 May 18;43(19):5716-27. [15134446 ] Baxter S, Royer S, Grogan G, Brown F, Holt-Tiffin KE, Taylor IN, Fotheringham IG, Campopiano DJ: An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids. J Am Chem Soc. 2012 Nov 28;134(47):19310-3. doi: 10.1021/ja305438y. Epub 2012 Nov 15. [23130969 ]

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