Carboxylesterase

Name	Carboxylesterase
Synonyms	3.1.1.1 est30
Gene Name	est
Organism	Geobacillus stearothermophilus
Amino acid sequence	>lcl\|BSEQ0037140\|Carboxylesterase MKIVPPKPFFFEAGERAVLLLHGFTGNSADVRMLGRFLESKGYTCHAPIYKGHGVPPEEL VHTGPDDWWQDVMNGYEFLKNKGYEKIAVAGLSLGGVFSLKLGYTVPIEGIVTMCAPMYI KSEETMYEGVLEYAREYKKREGKSEEQIEQEMEKFKQTPMKTLKALQELIADVRDHLDLI YAPTFVVQARHDEMINPDSANIIYNEIESPVKQIKWYEQSGHVITLDQEKDQLHEDIYAF LESLDW
Number of residues	None
Molecular Weight	28256.125
Theoretical pI	4.79
GO Classification	Functions carboxylic ester hydrolase activity Processes Components
General Function	Carboxylic ester hydrolase activity
Specific Function	Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q06174
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0002518\|744 bp ATGATGAAAATTGTTCCGCCGAAGCCGTTTTTCTTTGAAGCCGGGGAGCGGGCGGTGCTG CTGTTGCATGGGTTTACCGGCAATTCCGCTGATGTTCGGATGCTCGGGCGTTTTTTAGAA TCCAAAGGCTATACGTGCCATGCGCCTATTTACAAAGGACACGGCGTGCCGCCTGAGGAG CTCGTCCACACCGGGCCGGATGACTGGTGGCAAGATGTCATGAACGGCTACGAGTTTTTG AAAAACAAGGGCTACGAAAAAATCGCCGTCGCCGGACTGTCGCTTGGAGGCGTATTTTCA TTGAAATTAGGTTACACTGTACCTATAGAGGGCATTGTGACGATGTGCGCGCCGATGTAC ATCAAAAGCGAGGAAACGATGTACGAAGGCGTGCTCGAGTATGCGCGCGAGTATAAAAAG CGGGAAGGAAAATCAGAGGAGCAGATCGAACAGGAGATGGAGAAGTTCAAGCAGACGCCG ATGAAGACGTTAAAGGCGCTGCAGGAGCTGATCGCCGATGTGCGTGACCATCTTGATTTG ATTTATGCCCCGACGTTTGTTGTGCAGGCGCGCCATGATGAGATGATCAACCCGGACAGC GCGAACATCATTTATAACGAAATTGAATCGCCGGTCAAACAAATCAAGTGGTATGAGCAA TCAGGCCATGTGATTACGCTTGATCAAGAAAAAGATCAGCTGCATGAAGATATTTATGCA TTTCTTGAATCGTTAGATTGGTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Kugimiya W, Otani Y, Hashimoto Y: Molecular cloning and structure of the gene for esterase from a thermophilic bacterium, Bacillus stearothermophilus IFO 12550. Biosci Biotechnol Biochem. 1992 Dec;56(12):2074-5. [1369099 ] Ewis HE, Abdelal AT, Lu CD: Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus. Gene. 2004 Mar 31;329:187-95. [15033540 ] Liu P, Wang YF, Ewis HE, Abdelal AT, Lu CD, Harrison RW, Weber IT: Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30. J Mol Biol. 2004 Sep 10;342(2):551-61. [15327954 ]

From www.t3db.ca