Malate dehydrogenase

Name	Malate dehydrogenase
Synonyms	1.1.1.37
Gene Name	mdh
Organism	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Amino acid sequence	>lcl\|BSEQ0016371\|Malate dehydrogenase MRKKISIIGAGFVGSTTAHWLAAKELGDIVLLDFVEGVPQGKALDLYEASPIEGFDVRVT GTNNYADTANSDVIVVTSGAPRKPGMSREDLIKVNADITRACISQAAPLSPNAVIIMVNN PLDAMTYLAAEVSGFPKERVIGQAGVLDAARYRTFIAMEAGVSVEDVQAMLMGGHGDEMV PLPRFSTISGIPVSEFIAPDRLAQIVERTRKGGGEIVNLLKTGSAYYAPAAATAQMVEAV LKDKKRVMPVAAYLTGQYGLNDIYFGVPVILGAGGVEKILELPLNEEEMALLNASAKAVR ATLDTLKSL
Number of residues	None
Molecular Weight	32750.54
Theoretical pI	4.91
GO Classification	Functions L-malate dehydrogenase activity Processes tricarboxylic acid cycle carbohydrate metabolic process malate metabolic process Components
General Function	L-malate dehydrogenase activity
Specific Function	Catalyzes the reversible oxidation of malate to oxaloacetate.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P80040
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0016372\|Malate dehydrogenase (mdh) ATGCGCAAGAAGATTAGTATTATCGGGGCAGGATTTGTCGGTTCGACGACAGCTCACTGG CTGGCCGCTAAAGAATTAGGTGACATTGTTCTGCTTGATTTTGTCGAGGGTGTGCCTCAA GGCAAGGCTCTCGATCTCTACGAGGCATCACCAATTGAAGGGTTTGATGTTCGGGTGACC GGCACGAACAACTACGCCGATACTGCCAACTCGGATGTCATCGTTGTTACGTCAGGTGCT CCGCGCAAGCCGGGCATGAGCCGTGAGGATTTGATCAAGGTCAACGCCGACATCACCCGT GCCTGTATCAGTCAGGCTGCCCCGCTCTCGCCGAATGCCGTGATTATCATGGTCAATAAT CCTCTGGATGCGATGACCTATCTGGCGGCGGAGGTTAGTGGCTTCCCCAAAGAGCGTGTC ATTGGTCAGGCCGGCGTCCTCGATGCGGCCCGCTATCGCACCTTCATTGCCATGGAGGCG GGTGTTTCGGTTGAAGATGTTCAGGCGATGCTGATGGGTGGTCACGGCGATGAGATGGTA CCGCTGCCCCGGTTTTCAACCATTAGCGGTATTCCGGTGAGCGAGTTCATTGCGCCTGAT CGTCTGGCTCAGATTGTTGAGCGCACCCGGAAGGGTGGTGGCGAGATTGTGAATCTGCTG AAGACCGGCAGTGCGTATTATGCTCCCGCCGCCGCCACAGCGCAGATGGTCGAAGCGGTG CTCAAAGACAAGAAGCGGGTCATGCCGGTGGCAGCCTACCTGACCGGTCAGTACGGCCTG AATGATATTTACTTTGGTGTACCGGTGATCCTCGGTGCCGGTGGAGTAGAGAAAATTCTC GAATTGCCGCTCAACGAAGAGGAGATGGCACTGCTGAACGCATCGGCGAAAGCGGTACGT GCCACCCTCGACACGCTGAAGTCTCTCTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Synstad B, Emmerhoff O, Sirevag R: Malate dehydrogenase from the green gliding bacterium Chloroflexus aurantiacus is phylogenetically related to lactic dehydrogenases. Arch Microbiol. 1996 May;165(5):346-53. [8661927 ] Tang KH, Barry K, Chertkov O, Dalin E, Han CS, Hauser LJ, Honchak BM, Karbach LE, Land ML, Lapidus A, Larimer FW, Mikhailova N, Pitluck S, Pierson BK, Blankenship RE: Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. BMC Genomics. 2011 Jun 29;12:334. doi: 10.1186/1471-2164-12-334. [21714912 ] Rolstad AK, Howland E, Sirevag R: Malate dehydrogenase from the thermophilic green bacterium Chloroflexus aurantiacus: purification, molecular weight, amino acid composition, and partial amino acid sequence. J Bacteriol. 1988 Jul;170(7):2947-53. [3133356 ] Dalhus B, Saarinen M, Sauer UH, Eklund P, Johansson K, Karlsson A, Ramaswamy S, Bjork A, Synstad B, Naterstad K, Sirevag R, Eklund H: Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases. J Mol Biol. 2002 May 3;318(3):707-21. [12054817 ] Bjork A, Dalhus B, Mantzilas D, Eijsink VG, Sirevag R: Stabilization of a tetrameric malate dehydrogenase by introduction of a disulfide bridge at the dimer-dimer interface. J Mol Biol. 2003 Dec 5;334(4):811-21. [14636605 ]

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