(S)-2-haloacid dehalogenase

Name	(S)-2-haloacid dehalogenase
Synonyms	2-haloalkanoic acid dehalogenase 3.8.1.2 Halocarboxylic acid halidohydrolase L-2-haloacid dehalogenase
Gene Name	dhlB
Organism	Xanthobacter autotrophicus
Amino acid sequence	>lcl\|BSEQ0011144\|(S)-2-haloacid dehalogenase MIKAVVFDAYGTLFDVQSVADATERAYPGRGEYITQVWRQKQLEYSWLRALMGRYADFWG VTREALAYTLGTLGLEPDESFLADMAQAYNRLTPYPDAAQCLAELAPLKRAILSNGAPDM LQALVANAGLTDSFDAVISVDAKRVFKPHPDSYALVEEVLGVTPAEVLFVSSNGFDVGGA KNFGFSVARVARLSQEALARELVSGTIAPLTMFKALRMREETYAEAPDFVVPALGDLPRL VRGMAGAHLAPAV
Number of residues	None
Molecular Weight	27469.15
Theoretical pI	4.71
GO Classification	Functions (S)-2-haloacid dehalogenase activity Processes Components
General Function	(s)-2-haloacid dehalogenase activity
Specific Function	Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isomer of 2-chloropropionic acid with inversion of configuration to produce D-lactate.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q60099
UniProtKB Entry Name
Cellular Location	Cytoplasmic
Gene sequence	>lcl\|BSEQ0003200\|762 bp ATGATCAAGGCAGTCGTGTTCGACGCTTACGGTACGCTCTTCGACGTCCAGTCGGTGGCC GACGCCACCGAGCGGGCGTATCCAGGCCGGGGCGAGTACATCACGCAGGTCTGGCGGCAG AAGCAGCTGGAATACAGCTGGCTCCGCGCGCTGATGGGGCGCTATGCCGACTTTTGGGGC GTCACGCGGGAAGCGCTGGCCTATACCCTCGGAACGCTGGGGCTGGAGCCGGACGAGTCC TTCCTCGCCGGGATGGCGCAGGCCTACAACCGCCTCACGCCCTATCCGGACGCCGCGCAA TGCCTCGCGGAGCTGGCGCCCCTCAAGCGCGCCATCCTCTCCAACGGCGCGCCCGACATG CTGCAGGCGCTCGTGGCCAATGCGGGCCTGACGGACAGCTTCGATGCCGTCATCAGCGTC GATGCCAAGCGCGTGTTCAAGCCTCATCCCGACTCCTACGCGCTGGTGGAGGAGGTACTA GGCGTGACGCCCGCGGAGGTGCTGTTCGTGTCCTCCAACGGCTTCGACGTCGGCGGCGCG AAGAATTTCGGCTTCAGCGTCGCCCGGGTCGCGCGCCTGTCGCAGGAGGCGCTGGCGCGC GAACTCGTCTCGGGTACCATCGCGCCCCTGACCATGTTCAAGGCGCTGAGGATGCGGGAA GAAACCTATGCGGAGGCGCCTGATTTCGTGGTGCCCGCCCTTGGCGACCTGCCGCGGCTG GTTCGCGGGATGGCCGGCGCTCATCTCGCACCAGCGGTGTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	van der Ploeg J, van Hall G, Janssen DB: Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene. J Bacteriol. 1991 Dec;173(24):7925-33. [1744048 ] van der Ploeg J, Janssen DB: Sequence analysis of the upstream region of dhlB, the gene encoding haloalkanoic acid dehalogenase of Xanthobacter autotrophicus GJ10. Biodegradation. 1995 Sep;6(3):257-63. [7580000 ] Ridder IS, Rozeboom HJ, Kalk KH, Janssen DB, Dijkstra BW: Three-dimensional structure of L-2-haloacid dehalogenase from Xanthobacter autotrophicus GJ10 complexed with the substrate-analogue formate. J Biol Chem. 1997 Dec 26;272(52):33015-22. [9407083 ]

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