Glutaconyl-CoA decarboxylase subunit alpha

Name	Glutaconyl-CoA decarboxylase subunit alpha
Synonyms	4.1.1.70 Carboxyltransferase
Gene Name	gcdA
Organism	Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Amino acid sequence	>lcl\|BSEQ0011878\|Glutaconyl-CoA decarboxylase subunit alpha MGFYSMPRYFQNMPQVGKPLKKADAANEEQLKKIEEEIHQLIKEAQEAGKADADVNKRGE LTALQRIEKLVEPGSWRPLNTLFNPQGNKNGSVAIVKGLGRVNGKWCVVVASDNKKLAGA WVPGQAECLLRASDTAKTLHVPLVYVLNCSGVKFDEQEKVYPNRRGGGTPFFRNAELNQL GIPVIVGIYGTNPAGGGYHSISPTVIIAHEKANMAVGGAGIMGGMNPKGHVDLEYANEIA DMVDRTGKTEPPGAVDIHYTETGFMREVYASEEGVLEGIKKYVGMLPKYDPEFFRVDDPK APAFPADDLYSMVPLNDKRAYDIYNVIARLFDNSELHEYKKGYGPEMVTGLAKVNGLLVG VVANVQGLLMNYPEYKAAGSVGIGGKLYRQGLVKMNEFVTLCARDRLPIVWIQDTTGIDV GNDAEKAELLGLGQSLIYSIQTSHIPQFEITLRKGTAAAHYVLGGPQGNDTNAFSIGTAA TEIAVMNGETAATAMYSRRLAKDRKAGKDLQPTIDKMNNLIQAFYTKSRPKVCAELGLVD EIVDMNKIRGYVEAFTEAAYQNPESICPFHQMILPRAIREFETFVKK
Number of residues	None
Molecular Weight	64346.32
Theoretical pI	7.05
GO Classification	Functions ligase activity glutaconyl-CoA decarboxylase activity Processes sodium ion transport glutamate catabolic process via 2-hydroxyglutarate Components
General Function	Ligase activity
Specific Function	Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q06700
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0011879\|Glutaconyl-CoA decarboxylase subunit alpha (gcdA) ATGGGTTTCTACTCTATGCCTAGATATTTCCAAAATATGCCTCAGGTGGGCAAACCCCTG AAAAAGGCGGATGCCGCCAATGAAGAACAGCTGAAAAAGATCGAAGAAGAGATCCATCAG CTGATCAAAGAGGCTCAGGAAGCCGGCAAGGCAGATGCTGATGTAAACAAGAGAGGGGAA CTGACCGCTCTCCAGAGAATTGAAAAACTGGTGGAACCGGGCTCCTGGAGACCCCTGAAC ACCCTGTTCAACCCTCAGGGCAACAAGAACGGCTCCGTGGCCATCGTCAAGGGCCTGGGC CGTGTAAACGGCAAATGGTGCGTGGTCGTGGCTTCCGACAACAAGAAGCTGGCCGGTGCC TGGGTGCCAGGCCAGGCTGAATGCCTGCTGCGGGCTTCCGATACCGCCAAGACCCTGCAC GTGCCTCTGGTGTATGTGCTGAACTGCTCCGGCGTTAAGTTCGACGAACAGGAAAAGGTA TACCCCAACCGTCGTGGCGGCGGTACGCCTTTCTTCCGGAACGCTGAACTGAACCAGCTG GGCATTCCCGTCATCGTTGGCATCTACGGCACCAACCCTGCCGGCGGCGGCTATCATTCC ATCAGCCCCACGGTGATCATTGCCCATGAAAAAGCCAACATGGCTGTGGGCGGCGCCGGC ATTATGGGCGGCATGAACCCCAAAGGTCATGTGGACCTGGAATATGCCAACGAAATCGCC GACATGGTGGACCGTACCGGCAAGACCGAACCTCCGGGAGCTGTCGACATCCACTACACC GAAACCGGTTTCATGCGTGAAGTCTATGCTTCCGAAGAAGGCGTTCTGGAAGGGATCAAG AAGTATGTAGGCATGCTGCCGAAATACGATCCTGAATTCTTCCGGGTGGACGATCCGAAA GCACCGGCATTCCCGGCTGACGACCTGTACAGCATGGTTCCTCTGAACGACAAACGGGCT TATGACATCTACAATGTAATTGCCCGCCTGTTCGACAACAGCGAACTCCATGAATACAAA AAAGGCTACGGCCCTGAAATGGTCACCGGTCTGGCCAAAGTCAACGGCCTGCTGGTGGGC GTTGTGGCCAACGTCCAGGGTCTCCTGATGAACTACCCTGAATACAAGGCTGCAGGCTCC GTAGGGATCGGCGGCAAACTGTACCGCCAGGGTCTGGTGAAAATGAATGAATTCGTCACC CTGTGCGCCAGAGACCGTCTGCCCATCGTCTGGATCCAGGATACCACCGGGATCGATGTG GGCAACGATGCGGAAAAGGCTGAACTGCTGGGTCTGGGCCAGTCCCTGATCTACTCCATC CAGACTTCCCACATCCCTCAATTCGAAATTACCCTGAGAAAAGGCACGGCTGCTGCCCAC TACGTACTGGGCGGGCCTCAGGGCAATGACACCAACGCCTTCTCCATCGGTACCGCTGCT ACGGAAATCGCCGTTATGAACGGTGAAACCGCTGCCACCGCCATGTACTCCCGGAGACTG GCCAAAGACCGGAAAGCCGGCAAGGATCTGCAGCCGACCATCGACAAGATGAACAACCTG ATCCAGGCTTTCTACACCAAATCTCGTCCGAAAGTCTGTGCTGAACTGGGTCTGGTGGAT GAAATCGTGGACATGAACAAGATCCGCGGGTATGTGGAAGCCTTCACGGAAGCTGCTTAT CAGAATCCGGAAAGCATCTGCCCGTTCCATCAGATGATTCTGCCTCGTGCCATCAGAGAG TTTGAGACTTTCGTAAAGAAATAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Bendrat K, Buckel W: Cloning, sequencing and expression of the gene encoding the carboxytransferase subunit of the biotin-dependent Na+ pump glutaconyl-CoA decarboxylase from Acidaminococcus fermentans in Escherichia coli. Eur J Biochem. 1993 Feb 1;211(3):697-702. [8382157 ] Chang YJ, Pukall R, Saunders E, Lapidus A, Copeland A, Nolan M, Glavina Del Rio T, Lucas S, Chen F, Tice H, Cheng JF, Han C, Detter JC, Bruce D, Goodwin L, Pitluck S, Mikhailova N, Liolios K, Pati A, Ivanova N, Mavromatis K, Chen A, Palaniappan K, Land M, Hauser L, Jeffries CD, Brettin T, Rohde M, Goker M, Bristow J, Eisen JA, Markowitz V, Hugenholtz P, Kyrpides NC, Klenk HP: Complete genome sequence of Acidaminococcus fermentans type strain (VR4). Stand Genomic Sci. 2010 Jul 29;3(1):1-14. doi: 10.4056/sigs.1002553. [21304687 ] Bendrat K, Muller U, Klees AG, Buckel W: Identification of the gene encoding the activator of (R)-2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans by gene expression in Escherichia coli. FEBS Lett. 1993 Aug 30;329(3):329-31. [8365476 ] Muller U, Buckel W: Activation of (R)-2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. Eur J Biochem. 1995 Jun 1;230(2):698-704. [7607244 ] Wendt KS, Schall I, Huber R, Buckel W, Jacob U: Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase. EMBO J. 2003 Jul 15;22(14):3493-502. [12853465 ]

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