Glutathione S-transferase

NameGlutathione S-transferase
Synonyms
  • 2.5.1.18
  • PfGST
Gene NameGST
OrganismPlasmodium falciparum
Amino acid sequence
>lcl|BSEQ0019314|Glutathione S-transferase
MGDNIVLYYFDARGKAELIRLIFAYLGIEYTDKRFGVNGDAFVEFKNFKKEKDTPFEQVP
ILQIGDLILAQSQAIVRYLSKKYNICGESELNEFYADMIFCGVQDIHYKFNNTNLFKQNE
TTFLNEDLPKWSGYFEKLLKKNHTNNNNDKYYFVGNNLTYADLAVFNLYDDIETKYPSSL
KNFPLLKAHNEFISNLPNIKNYITNRKESVY
Number of residuesNone
Molecular Weight24788.9
Theoretical pI6.28
GO Classification
Functions
  • glutathione transferase activity
Processes
Components
General FunctionGlutathione transferase activity
Specific FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ8MU52
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0005215|642 bp
ATGAAGCTTGGAGATAATATAGTGTTATATTATTTTGATGCAAGGGGTAAAGCTGAATTG
ATAAGATTAATTTTTGCCTACCTTGGAATAGAATATACAGATAAAAGATTTGGAGTAAAC
GGTGATGCTTTTGTTGAATTTAAAAATTTTAAAAAAGAAAAGGATACTCCTTTTGAGCAA
GTACCCATATTACAAATTGGAGATTTGATATTAGCTCAAAGCCAAGCTATAGTTCGTTAT
TTATCAAAAAAATATAATATATGTGGTGAAAGTGAATTGAATGAATTTTATGCAGATATG
ATATTTTGTGGTGTTCAGGATATTCATTATAAATTTAATAATACCAATTTATTTAAACAA
AATGAAACAACTTTTTTAAATGAGGATTTACCAAAATGGTCAGGTTATTTTGAGAAACTT
TTAAAAAAAAATCATACAAATAATAATAATGATAAATATTATTTTGTAGGTAATAATTTA
ACATATGCTGACCTAGCTGTTTTTAATTTATATGATGATATTGAAACAAAATATCCAAGT
AGCTTGAAAAATTTCCCTTTATTAAAAGCTCATAATGAATTTATAAGTAACTTGCCTAAT
ATCAAAAATTATATAACTAATAGAAAAGAAAGTGTATACTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Harwaldt P, Rahlfs S, Becker K: Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target. Biol Chem. 2002 May;383(5):821-30. [12108547 ]
  2. Liebau E, Bergmann B, Campbell AM, Teesdale-Spittle P, Brophy PM, Luersen K, Walter RD: The glutathione S-transferase from Plasmodium falciparum. Mol Biochem Parasitol. 2002 Sep-Oct;124(1-2):85-90. [12387854 ]
  3. Liebau E, De Maria F, Burmeister C, Perbandt M, Turella P, Antonini G, Federici G, Giansanti F, Stella L, Lo Bello M, Caccuri AM, Ricci G: Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum. J Biol Chem. 2005 Jul 15;280(28):26121-8. Epub 2005 May 11. [15888443 ]
  4. Fritz-Wolf K, Becker A, Rahlfs S, Harwaldt P, Schirmer RH, Kabsch W, Becker K: X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13821-6. Epub 2003 Nov 17. [14623980 ]
  5. Perbandt M, Burmeister C, Walter RD, Betzel C, Liebau E: Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum. J Biol Chem. 2004 Jan 9;279(2):1336-42. Epub 2003 Sep 12. [12972411 ]
  6. Hiller N, Fritz-Wolf K, Deponte M, Wende W, Zimmermann H, Becker K: Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition. Protein Sci. 2006 Feb;15(2):281-9. Epub 2005 Dec 29. [16385005 ]

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