Response regulator PleD

Name	Response regulator PleD
Synonyms	Stalked cell differentiation-controlling protein
Gene Name	pleD
Organism	Caulobacter crescentus (strain ATCC 19089 / CB15)
Amino acid sequence	>lcl\|BSEQ0016378\|Response regulator PleD MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMD GFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLT RFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPV IESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRM VKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNR RYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRA IDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSAT AGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA
Number of residues	None
Molecular Weight	49623.365
Theoretical pI	5.77
GO Classification	Functions signal transducer activity GTP binding metal ion binding diguanylate cyclase activity Processes cell cycle cell differentiation phosphorelay signal transduction system Components cytoplasm
General Function	Signal transducer activity
Specific Function	Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition.Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q9A5I5
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0016379\|Response regulator PleD (pleD) ATGAGCGCCCGGATCCTCGTCGTCGACGACATCGAGGCCAATGTCCGCCTGCTTGAGGCC AAGCTGACGGCCGAGTACTATGAGGTCTCCACCGCCATGGACGGGCCGACGGCCCTGGCT ATGGCCGCGCGCGATCTGCCCGACATCATTCTGCTGGACGTCATGATGCCCGGCATGGAC GGCTTCACCGTCTGCCGTAAGCTGAAGGACGATCCGACTACCCGCCACATCCCGGTGGTG CTGATCACCGCGCTCGACGGGCGTGGCGACCGCATCCAGGGCCTGGAATCGGGCGCTTCG GACTTCCTGACCAAGCCGATCGACGACGTCATGCTGTTCGCCCGCGTGCGCAGCCTGACC CGCTTCAAGCTGGTGATCGACGAACTGCGTCAGCGCGAGGCCTCGGGCCGCCGCATGGGC GTGATCGCCGGCGCCGCCGCGCGCCTGGACGGTCTGGGCGGTCGGGTGCTGATCGTCGAC GACAACGAACGCCAGGCTCAACGCGTCGCCGCCGAGCTGGGCGTCGAACACCGCCCGGTG ATCGAGAGCGACCCTGAGAAGGCCAAGATCAGCGCCGGCGGTCCGGTCGACCTGGTCATC GTCAACGCTGCGGCCAAGAACTTCGATGGCCTGCGCTTCACCGCCGCGCTGCGGTCCGAG GAACGCACCCGCCAGTTGCCCGTGCTGGCCATGGTCGATCCCGATGATCGTGGCCGCATG GTCAAGGCGCTGGAGATCGGCGTGAACGACATCCTGTCGCGCCCGATCGATCCGCAGGAA CTGTCCGCGCGCGTCAAGACGCAGATCCAGCGCAAGCGCTACACTGACTATCTGCGCAAC AATCTGGATCACTCGCTGGAGCTGGCCGTCACCGACCAGCTGACCGGCCTGCACAATCGC CGCTACATGACCGGTCAGCTCGACTCGCTGGTCAAGCGCGCGACACTGGGCGGCGATCCG GTTTCGGCCCTGCTGATCGACATCGATTTCTTCAAGAAAATCAACGACACCTTCGGTCAC GATATCGGCGACGAGGTGCTGCGCGAGTTCGCCTTGCGTCTGGCCTCGAACGTCCGCGCC ATTGATCTGCCTTGCCGCTATGGCGGGGAAGAGTTCGTGGTGATCATGCCCGACACCGCC CTGGCTGACGCCCTGCGCATCGCCGAGCGGATCCGGATGCATGTCTCCGGCTCGCCCTTC ACGGTCGCCCATGGCCGCGAAATGCTGAACGTCACCATCTCGATCGGCGTCTCGGCCACG GCGGGCGAGGGCGACACGCCCGAAGCCCTGCTCAAGCGCGCCGACGAAGGCGTTTATCAG GCCAAGGCCTCGGGTCGGAACGCGGTGGTCGGCAAGGCCGCCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Hecht GB, Newton A: Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. [7592388 ] Nierman WC, Feldblyum TV, Laub MT, Paulsen IT, Nelson KE, Eisen JA, Heidelberg JF, Alley MR, Ohta N, Maddock JR, Potocka I, Nelson WC, Newton A, Stephens C, Phadke ND, Ely B, DeBoy RT, Dodson RJ, Durkin AS, Gwinn ML, Haft DH, Kolonay JF, Smit J, Craven MB, Khouri H, Shetty J, Berry K, Utterback T, Tran K, Wolf A, Vamathevan J, Ermolaeva M, White O, Salzberg SL, Venter JC, Shapiro L, Fraser CM: Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4136-41. Epub 2001 Mar 20. [11259647 ]

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