Aliphatic amidase expression-regulating protein

Name	Aliphatic amidase expression-regulating protein
Synonyms
Gene Name	amiC
Organism	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence	>lcl\|BSEQ0016430\|Aliphatic amidase expression-regulating protein MGSHQERPLIGLLFSETGVTADIERSQRYGALLAVEQLNREGGVGGRPIETLSQDPGGDP DRYRLCAEDFIRNRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGFEYSPNIVYG GPAPNQNSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQHGGTVLEEIYIPLY PSDDDVQRAVERIYQARADVVFSTVVGTGTAELYRAIARRYGDGRRPPIASLTTSEAEVA KMESDVAEGQVVVAPYFSSIDTAASRAFVQACHGFFPENATITAWAEAAYWQTLLLGRAA QAAGSWRVEDVQRHLYDICIDAPQGPVRVERQNNHSRLSSRIAEIDARGVFQVRWQSPEP IRPDPYVVVHNLDDWSASMGGGALP
Number of residues	None
Molecular Weight	42806.69
Theoretical pI	5.82
GO Classification	Functions kinase activity amide binding Processes amino acid transport negative regulation of hydrolase activity regulation of cellular amide catabolic process Components
General Function	Kinase activity
Specific Function	Negatively regulates the expression of the aliphatic amidase operon. AmiC functions by inhibiting the action of AmiR at the protein level. It exhibits protein kinase activity.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P27017
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0016431\|Aliphatic amidase expression-regulating protein (amiC) ATGGGATCGCACCAGGAGCGGCCGCTGATCGGCCTGCTGTTCTCCGAAACCGGCGTCACC GCCGATATCGAGCGCTCGCAGCGCTATGGCGCATTGCTTGCGGTCGAGCAACTGAACCGC GAGGGCGGCGTCGGCGGTCGCCCGATCGAAACGCTGTCCCAGGACCCCGGCGGCGATCCG GACCGCTATCGGCTGTGCGCCGAGGACTTCATTCGCAACCGGGGGGTACGGTTCCTCGTG GGCTGCTACATGTCGCACACGCGCAAGGCGGTGATGCCGGTGGTCGAGCGCGCCGACGCG CTGCTCTGCTACCCGACTCCCTACGAGGGCTTCGAGTATTCGCCGAACATCGTCTACGGC GGTCCGGCGCCGAACCAGAACAGTGCGCCGCTGGCGGCGTACCTGATTCGCCACTACGGC GAGCGGGTGGTGTTCATCGGCTCGGACTACATCTATCCGCGGGAAAGCAACCATGTGATG CGCCACCTGTACCGCCAGCACGGCGGCACGGTGCTCGAGGAAATCTACATTCCGCTGTAT CCCTCCGACGACGACGTGCAGCGCGCCGTCGAGCGCATCTACCAGGCGCGCGCCGACGTG GTCTTCTCCACCGTGGTGGGCACCGGCACCGCCGAGCTGTATCGCGCCATCGCCCGTCGC TACGGCGATGGCAGGCGGCCGCCGATCGCCAGCCTGACCACCAGCGAGGCGGAGGTGGCG AAGATGGAGAGCGACGTGGCGGAGGGGCAGGTGGTGGTCGCGCCGTACTTCTCCAGCATC GATACGGCCGCCAGCCGCGCCTTCGTCCAGGCCTGCCATGGCTTCTTCCCGGAAAACGCG ACCATCACCGCCTGGGCCGAGGCGGCCTACTGGCAGACCTTGCTGCTTGGCCGCGCCGCG CAGGCCGCAGGCAGTTGGCGAGTGGAAGACGTGCAGCGGCACCTGTACGACATTTGCATC GACGCGCCCCAGGGGCCGGTCCGGGTGGAGCGCCAGAACAACCACAGCCGCCTGTCTTCG CGCATCGCGGAAATCGATGCGCGCGGCGTGTTCCAGGTCCGCTGGCAGTCGCCCGAACCG ATTCGCCCCGATCCTTATGTCGTCGTGCATAACCTCGACGACTGGTCCGCCAGCATGGGC GGGGGAGCGCTCCCATGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Wilson S, Drew R: Cloning and DNA sequence of amiC, a new gene regulating expression of the Pseudomonas aeruginosa aliphatic amidase, and purification of the amiC product. J Bacteriol. 1991 Aug;173(16):4914-21. [1907262 ] Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [10984043 ] Wilson SA, Chayen NE, Hemmings AM, Drew RE, Pearl LH: Crystallization of and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. J Mol Biol. 1991 Dec 20;222(4):869-71. [1762155 ] Pearl L, O'Hara B, Drew R, Wilson S: Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. EMBO J. 1994 Dec 15;13(24):5810-7. [7813419 ] O'Hara BP, Norman RA, Wan PT, Roe SM, Barrett TE, Drew RE, Pearl LH: Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex. EMBO J. 1999 Oct 1;18(19):5175-86. [10508151 ] O'Hara BP, Wilson SA, Lee AW, Roe SM, Siligardi G, Drew RE, Pearl LH: Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC. Protein Eng. 2000 Feb;13(2):129-32. [10708652 ]

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