Holliday junction ATP-dependent DNA helicase RuvB

Name	Holliday junction ATP-dependent DNA helicase RuvB
Synonyms	3.6.4.12
Gene Name	ruvB
Organism	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence	>lcl\|BSEQ0011070\|Holliday junction ATP-dependent DNA helicase RuvB MSEFLTPERTVYDSGVQFLRPKSLDEFIGQENVKKKLSLALEAAKMRGEVLDHVLLAGPP GLGKTTLAHIIASELQTNIHVTSGPVLVKQGDMAAILTSLERGDVLFIDEIHRLNKAVEE LLYSAIEDFQIDIMIGKGPSAKSIRIDIQPFTLVGATTRSGLLSSPLRSRFGIILELDFY TVKELKEIIKRAASLMDVEIEDAAAEMIAKRSRGTPRIAIRLTKRVRDMLTVVKADRINT DIVLKTMEVLNIDDEGLDEFDRKILKTIIEIYRGGPVGLNALAASLGVEADTLSEVYEPY LLQAGFLARTPRGRIVTEKAYKHLKYEVPENRLF
Number of residues	None
Molecular Weight	37155.775
Theoretical pI	6.39
GO Classification	Functions ATP binding DNA binding four-way junction helicase activity Processes DNA repair DNA recombination SOS response Components
General Function	Four-way junction helicase activity
Specific Function	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q56313
UniProtKB Entry Name
Cellular Location	Cytoplasmic
Gene sequence	>lcl\|BSEQ0011071\|Holliday junction ATP-dependent DNA helicase RuvB (ruvB) GTGAGTGAATTTCTCACACCTGAAAGGACCGTTTACGACTCTGGTGTACAGTTTCTAAGG CCCAAAAGCCTCGATGAATTCATTGGTCAGGAAAACGTGAAAAAGAAACTCTCCCTCGCT CTCGAAGCCGCGAAGATGAGGGGAGAAGTGCTCGATCATGTCCTCCTCGCAGGACCACCG GGACTCGGAAAGACGACCCTTGCACACATAATCGCCAGCGAACTCCAGACGAACATCCAC GTTACGAGCGGACCGGTTCTTGTGAAACAGGGAGATATGGCCGCTATCCTCACAAGTCTG GAACGGGGAGACGTTCTTTTCATAGACGAAATACACCGATTGAACAAGGCAGTGGAAGAG CTTCTTTACTCTGCCATCGAAGACTTCCAGATAGACATCATGATCGGAAAGGGCCCGAGT GCAAAGTCCATTAGGATAGACATCCAGCCTTTTACGCTCGTTGGAGCCACGACGAGAAGT GGTCTTTTGAGTTCTCCTCTCAGAAGCAGGTTTGGTATCATCCTCGAACTGGACTTCTAC ACTGTGAAAGAACTGAAGGAAATCATAAAAAGAGCGGCCAGCTTGATGGACGTTGAGATA GAAGACGCAGCAGCAGAGATGATCGCGAAAAGATCGAGAGGCACACCGAGGATCGCTATA AGACTCACGAAGAGAGTGAGGGACATGCTCACGGTGGTAAAGGCAGACAGAATCAATACC GATATCGTTTTGAAGACCATGGAAGTTCTGAACATAGACGACGAGGGACTTGATGAGTTC GACAGGAAGATCCTGAAGACGATCATAGAGATTTACAGGGGAGGCCCCGTCGGATTGAAC GCCCTCGCCGCTTCACTCGGTGTAGAAGCGGACACCCTGAGCGAAGTTTATGAACCTTAC CTCCTCCAGGCAGGATTCCTCGCCAGAACTCCCAGAGGAAGGATCGTCACTGAAAAGGCT TACAAACACCTGAAGTACGAAGTCCCGGAAAACCGTCTTTTCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Tong J, Wetmur JG: Cloning, sequencing, and expression of ruvB and characterization of RuvB proteins from two distantly related thermophilic eubacteria. J Bacteriol. 1996 May;178(9):2695-700. [8626340 ] Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [10360571 ]

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