Acetolactate synthase, catabolic

Name	Acetolactate synthase, catabolic
Synonyms	2.2.1.6 ALS ilvK
Gene Name	budB
Organism	Klebsiella pneumoniae
Amino acid sequence	>lcl\|BSEQ0019135\|Acetolactate synthase, catabolic MDKQYPVRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLDSSIRIIPVRHEANA AFMAAAVGRITGKAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQ SMDTVAMFSPVTKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPVSGKV LPASGAPQMGAAPDDAIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVTS TYQAAGAVNQDNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNATL VHIDVLPAYEERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEILRDRQHQRELLD RRGAQLNQFALHPLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYTFRARQVMISNGQQ TMGVALPWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLIWVDNGYNMV AIQEEKKYQRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMDVDGPAVVAIP VDYRDNPLLMGQLHLSQIL
Number of residues	None
Molecular Weight	60337.52
Theoretical pI	5.99
GO Classification	Functions magnesium ion binding thiamine pyrophosphate binding acetolactate synthase activity Processes butanediol metabolic process Components
General Function	Thiamine pyrophosphate binding
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P27696
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0003039\|1680 bp ATGGACAAACAGTATCCGGTACGCCAGTGGGCGCACGGCGCCGATCTCGTCGTCAGTCAG CTGGAAGCTCAGGGAGTACGCCAGGTGTTCGGCATCCCCGGCGCCAAAATCGACAAGGTC TTTGATTCACTGCTGGATTCCTCCATTCGCATTATTCCGGTACGCCACGAAGCCAACGCC GCATTTATGGCCGCCGCCGTCGGACGCATTACCGGCAAAGCGGGCGTGGCGCTGGTCACC TCCGGTCCGGGCTGTTCCAACCTGATCACCGGCATGGCCACCGCGAACAGCGAAGGCGAC CCGGTGGTGGCCCTGGGCGGCGCGGTAAAACGCGCCGATAAAGCGAAGCAGGTCCACCAG AGTATGGATACGGTGGCGATGTTCAGCCCGGTCACCAAATACGCCATCGAGGTGACGGCG CCGGATGCGCTGGCGGAAGTGGTCTCCAACGCCTTCCGCGCCGCCGAGCAGGGCCGGCCG GGCAGCGCGTTCGTTAGCCTGCCGCAGGATGTGGTCGATGGCCCGGTCAGCGGCAAAGTG CTGCCGGCCAGCGGGGCCCCGCAGATGGGCGCCGCGCCGGATGATGCCATCGACCAGGTG GCGAAGCTTATCGCCCAGGCGAAGAACCCGATCTTCCTGCTCGGCCTGATGGCCAGCCAG CCGGAAAACAGCAAGGCGCTGCGCCGTTTGCTGGAGACCAGCCATATTCCAGTCACCAGC ACCTATCAGGCCGCCGGAGCGGTGAATCAGGATAACTTCTCTCGCTTCGCCGGCCGGGTT GGGCTGTTTAACAACCAGGCCGGGGACCGTCTGCTGCAGCTCGCCGACCTGGTGATCTGC ATCGGCTACAGCCCGGTGGAATACGAACCGGCGATGTGGAACAGCGGCAACGCGACGCTG GTGCACATCGACGTGCTGCCCGCCTATGAAGAGCGCAACTACACCCCGGATGTCGAGCTG GTGGGCGATATCGCCGGCACTCTCAACAAGCTGGCGCAAAATATCGATCATCGGCTGGTG CTCTCCCCGCAGGCGGCGGAGATCCTCCGCGACCGCCAGCACCAGCGCGAGCTGCTGGAC CGCCGCGGCGCGCAGCTCAACCAGTTTGCCCTGCATCCCCTGCGCATCGTTCGCGCCATG CAGGATATCGTCAACAGCGACGTCACGTTGACCGTGGACATGGGCAGCTTCCATATCTGG ATTGCCCGCTACCTGTACACGTTCCGCGCCCGTCAGGTGATGATCTCCAACGGCCAGCAG ACCATGGGCGTCGCCCTGCCCTGGGCTATCGGCGCCTGGCTGGTCAATCCTGAGCGCAAA GTGGTCTCCGTCTCCGGCGACGGCGGCTTCCTGCAGTCGAGCATGGAGCTGGAGACCGCC GTCCGCCTGAAAGCCAACGTGCTGCATCTTATCTGGGTCGATAACGGCTACAACATGGTC GCTATCCAGGAAGAGAAAAAATATCAGCGCCTGTCCGGCGTCGAGTTTGGGCCGATGGAT TTTAAAGCCTATGCCGAATCCTTCGGCGCGAAAGGGTTTGCCGTGGAAAGCGCCGAGGCG CTGGAGCCGACCCTGCGCGCGGCGATGGACGTCGACGGCCCGGCGGTAGTGGCCATCCCG GTGGATTATCGCGATAACCCGCTGCTGATGGGCCAGCTGCATCTGAGTCAGATTCTGTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Peng HL, Wang PY, Wu CM, Hwang DC, Chang HY: Cloning, sequencing and heterologous expression of a Klebsiella pneumoniae gene encoding an FAD-independent acetolactate synthase. Gene. 1992 Aug 1;117(1):125-30. [1644303 ] Pang SS, Duggleby RG, Schowen RL, Guddat LW: The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem. 2004 Jan 16;279(3):2242-53. Epub 2003 Oct 13. [14557277 ]

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