Nicotinate-nucleotide pyrophosphorylase [carboxylating]

NameNicotinate-nucleotide pyrophosphorylase [carboxylating]
Synonyms
  • 2.4.2.19
  • QAPRTase
  • Quinolinate phosphoribosyltransferase [decarboxylating]
Gene NamenadC
OrganismMycobacterium tuberculosis
Amino acid sequence
>lcl|BSEQ0051199|Nicotinate-nucleotide pyrophosphorylase [carboxylating]
MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVAL
LTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATA
TAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAG
SVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRA
PTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
Number of residuesNone
Molecular Weight29950.79
Theoretical pINone
GO Classification
Functions
  • nicotinate-nucleotide diphosphorylase (carboxylating) activity
Processes
  • NAD biosynthetic process
  • quinolinate catabolic process
Components
  • cytoplasm
  • plasma membrane
  • cell wall
General FunctionInvolved in the catabolism of quinolinic acid (QA).
Specific FunctionNicotinate-nucleotide diphosphorylase (carboxylating) activity
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP9WJJ7
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0051200|Nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC)
ATGGGGTTATCCGACTGGGAGCTGGCTGCGGCTCGAGCAGCAATCGCGCGTGGGCTCGAC
GAGGACCTCCGGTACGGCCCGGATGTCACCACATTGGCGACGGTGCCTGCCAGTGCGACG
ACCACCGCATCGCTGGTGACCCGGGAGGCCGGTGTGGTTGCCGGATTGGATGTCGCGCTG
CTGACGCTGAACGAAGTCCTGGGCACCAACGGTTATCGGGTGCTCGACCGCGTCGAGGAC
GGCGCCCGGGTGCCGCCGGGAGAGGCACTTATGACGCTGGAAGCCCAAACGCGCGGATTG
TTGACCGCCGAGCGCACCATGTTGAACCTGGTCGGTCACCTGTCGGGAATCGCCACCGCG
ACGGCCGCGTGGGTCGATGCTGTGCGCGGGACCAAAGCGAAAATCCGCGATACCCGTAAG
ACGCTGCCCGGCCTGCGCGCGCTGCAAAAATACGCGGTGCGTACCGGTGGCGGCGTCAAC
CATCGGCTGGGGTTGGGTGATGCCGCGCTAATCAAGGACAACCACGTTGCCGCCGCCGGA
TCCGTGGTAGACGCGCTACGTGCGGTGCGAAATGCTGCACCCGATCTGCCGTGCGAGGTG
GAAGTGGACTCGCTTGAGCAGCTCGATGCCGTGCTGCCGGAAAAACCCGAGCTGATCCTG
CTGGACAATTTTGCGGTGTGGCAGACGCAGACCGCGGTGCAGCGTCGGGACTCGCGCGCG
CCCACCGTCATGCTGGAGTCATCCGGTGGGCTCAGCCTGCAGACGGCGGCGACCTACGCC
GAAACCGGGGTGGACTACCTGGCGGTCGGGGCGCTCACACACTCAGTGCGCGTGCTCGAC
ATCGGCTTGGATATGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [9634230 ]
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [21969609 ]
  3. Sharma V, Grubmeyer C, Sacchettini JC: Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure. 1998 Dec 15;6(12):1587-99. [9862811 ]

From www.t3db.ca