Beta-lactamase CTX-M


NameBeta-lactamase CTX-M
Synonyms
  • 3.5.2.6
  • beta-lactamase CTX-M-14
  • bla-CTX-M-14a
  • blaCTX-M-14a
  • blaCTX-M-14b
  • blaCTX-M-14c
  • blaCTX-M-27b
  • blatoho-3
  • blaUOE-2
  • CTX-M-14
Gene NameblaCTX-M-14
OrganismEscherichia coli
Amino acid sequence
>lcl|BSEQ0005545|Beta-lactamase
MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQ
VLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTM
TLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDP
RDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGS
GDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL
Number of residuesNone
Molecular Weight30979.09
Theoretical pI9.38
GO Classification
Functions
  • beta-lactamase activity
Processes
  • response to antibiotic
  • beta-lactam antibiotic catabolic process
Components
General FunctionNone
Specific FunctionBeta-lactamase activity
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9L5C7
UniProtKB Entry Name
Cellular LocationCytoplasmic
Gene sequence
>lcl|BSEQ0005544|876 bp
ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTG
CTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTG
GAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAG
GTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCC
GCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATC
AAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATG
ACGCTGGCAGAACTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAA
TTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGAT
GAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCG
AGAGACACCACCACGCCGCGGGCGATGGCGCAGACGTTGCGTCAGCTTACGCTGGGTCAT
GCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGC
GCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGTGGGTGATAAGACCGGCAGC
GGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTG
GTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTG
GCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Chanawong A, M'Zali FH, Heritage J, Xiong JH, Hawkey PM: Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China. Antimicrob Agents Chemother. 2002 Mar;46(3):630-7. [11850241 ]
  2. Saladin M, Cao VT, Lambert T, Donay JL, Herrmann JL, Ould-Hocine Z, Verdet C, Delisle F, Philippon A, Arlet G: Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS Microbiol Lett. 2002 Apr 9;209(2):161-8. [12007800 ]
  3. Chen Y, Shoichet B, Bonnet R: Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases. J Am Chem Soc. 2005 Apr 20;127(15):5423-34. [15826180 ]
  4. Ishii Y, Kimura S, Alba J, Shiroto K, Otsuka M, Hashizume N, Tamura K, Yamaguchi K: Extended-spectrum beta-lactamase-producing Shiga toxin gene (Stx1)-positive Escherichia coli O26:H11: a new concern. J Clin Microbiol. 2005 Mar;43(3):1072-5. [15750063 ]
  5. Chen Y, Delmas J, Sirot J, Shoichet B, Bonnet R: Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability. J Mol Biol. 2005 Apr 29;348(2):349-62. [15811373 ]
  6. Eckert C, Gautier V, Arlet G: DNA sequence analysis of the genetic environment of various blaCTX-M genes. J Antimicrob Chemother. 2006 Jan;57(1):14-23. Epub 2005 Nov 16. [16291869 ]
  7. Bae IK, Lee YN, Lee WG, Lee SH, Jeong SH: Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene. Antimicrob Agents Chemother. 2007 Aug;51(8):3017-9. Epub 2007 May 21. [17517851 ]
  8. Navarro F, Mesa RJ, Miro E, Gomez L, Mirelis B, Coll P: Evidence for convergent evolution of CTX-M-14 ESBL in Escherichia coli and its prevalence. FEMS Microbiol Lett. 2007 Aug;273(1):120-3. Epub 2007 Jun 7. [17559406 ]
  9. Ho PL, Poon WW, Loke SL, Leung MS, Chow KH, Wong RC, Yip KS, Lai EL, Tsang KW: Community emergence of CTX-M type extended-spectrum beta-lactamases among urinary Escherichia coli from women. J Antimicrob Chemother. 2007 Jul;60(1):140-4. Epub 2007 May 11. [17496058 ]
  10. Zong Z, Partridge SR, Thomas L, Iredell JR: Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool. Antimicrob Agents Chemother. 2008 Nov;52(11):4198-202. doi: 10.1128/AAC.00107-08. Epub 2008 Aug 25. [18725449 ]
  11. Bae IK, Lee YH, Jeong HJ, Hong SG, Lee SH, Jeong SH: A novel bla(CTX-M-14) gene-harboring complex class 1 integron with an In4-like backbone structure from a clinical isolate of Escherichia coli. Diagn Microbiol Infect Dis. 2008 Nov;62(3):340-2. doi: 10.1016/j.diagmicrobio.2008.06.006. Epub 2008 Aug 13. [18703304 ]
  12. Valverde A, Canton R, Garcillan-Barcia MP, Novais A, Galan JC, Alvarado A, de la Cruz F, Baquero F, Coque TM: Spread of bla(CTX-M-14) is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain. Antimicrob Agents Chemother. 2009 Dec;53(12):5204-12. doi: 10.1128/AAC.01706-08. Epub 2009 Sep 28. [19786598 ]
  13. Liu W, Chen L, Li H, Duan H, Zhang Y, Liang X, Li X, Zou M, Xu L, Hawkey PM: Novel CTX-M {beta}-lactamase genotype distribution and spread into multiple species of Enterobacteriaceae in Changsha, Southern China. J Antimicrob Chemother. 2009 May;63(5):895-900. doi: 10.1093/jac/dkp068. Epub 2009 Mar 18. [19297379 ]
  14. Yuan L, Liu JH, Hu GZ, Pan YS, Liu ZM, Mo J, Wei YJ: Molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolates from chickens in Henan Province, China. J Med Microbiol. 2009 Nov;58(Pt 11):1449-53. doi: 10.1099/jmm.0.012229-0. Epub 2009 Jul 2. [19574412 ]
  15. Ben Slama K, Ben Sallem R, Jouini A, Rachid S, Moussa L, Saenz Y, Estepa V, Somalo S, Boudabous A, Torres C: Diversity of genetic lineages among CTX-M-15 and CTX-M-14 producing Escherichia coli strains in a Tunisian hospital. Curr Microbiol. 2011 Jun;62(6):1794-801. doi: 10.1007/s00284-011-9930-4. Epub 2011 Apr 10. [21479796 ]
  16. Ho PL, Lo WU, Wong RC, Yeung MK, Chow KH, Que TL, Tong AH, Bao JY, Lok S, Wong SS: Complete sequencing of the FII plasmid pHK01, encoding CTX-M-14, and molecular analysis of its variants among Escherichia coli from Hong Kong. J Antimicrob Chemother. 2011 Apr;66(4):752-6. doi: 10.1093/jac/dkr010. Epub 2011 Feb 7. [21393220 ]
  17. Kim J, Bae IK, Jeong SH, Chang CL, Lee CH, Lee K: Characterization of IncF plasmids carrying the blaCTX-M-14 gene in clinical isolates of Escherichia coli from Korea. J Antimicrob Chemother. 2011 Jun;66(6):1263-8. doi: 10.1093/jac/dkr106. Epub 2011 Mar 17. [21415040 ]
  18. Tacao M, Correia A, Henriques I: Resistance to broad-spectrum antibiotics in aquatic systems: anthropogenic activities modulate the dissemination of bla(CTX-M)-like genes. Appl Environ Microbiol. 2012 Jun;78(12):4134-40. doi: 10.1128/AEM.00359-12. Epub 2012 Apr 6. [22492443 ]
  19. Kang MS, Kwon YK, Oh JY, Kim MJ, Call DR, An BK, Shin EG, Song EA, Kwon JH: Evidence for recent acquisition and successful transmission of bla(CTX-M-15) in Salmonella enterica in South Korea. Antimicrob Agents Chemother. 2013 May;57(5):2383-7. doi: 10.1128/AAC.01854-12. Epub 2013 Feb 25. [23439639 ]
  20. Stokes MO, Abuoun M, Umur S, Wu G, Partridge SR, Mevius DJ, Coldham NG, Fielder MD: Complete sequence of pSAM7, an IncX4 plasmid carrying a novel blaCTX-M-14b transposition unit isolated from Escherichia coli and Enterobacter cloacae from cattle. Antimicrob Agents Chemother. 2013 Sep;57(9):4590-4. doi: 10.1128/AAC.01157-13. Epub 2013 Jul 8. [23836183 ]
  21. Ho PL, Chan J, Lo WU, Law PY, Li Z, Lai EL, Chow KH: Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals. J Appl Microbiol. 2013 Mar;114(3):695-702. doi: 10.1111/jam.12099. Epub 2012 Dec 27. [23216653 ]
  22. Sato N, Kawamura K, Nakane K, Wachino J, Arakawa Y: First detection of fosfomycin resistance gene fosA3 in CTX-M-producing Escherichia coli isolates from healthy individuals in Japan. Microb Drug Resist. 2013 Dec;19(6):477-82. doi: 10.1089/mdr.2013.0061. Epub 2013 Aug 3. [23909549 ]
  23. Hansen KH, Bortolaia V, Damborg P, Guardabassi L: Strain diversity of CTX-M-producing Enterobacteriaceae in individual pigs: insights into the dynamics of shedding during the production cycle. Appl Environ Microbiol. 2014 Nov;80(21):6620-6. doi: 10.1128/AEM.01730-14. Epub 2014 Aug 15. [25128344 ]
  24. Rao L, Lv L, Zeng Z, Chen S, He D, Chen X, Wu C, Wang Y, Yang T, Wu P, Liu Y, Liu JH: Increasing prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in food animals and the diversity of CTX-M genotypes during 2003-2012. Vet Microbiol. 2014 Aug 27;172(3-4):534-41. doi: 10.1016/j.vetmic.2014.06.013. Epub 2014 Jun 22. [24999233 ]
  25. Zhang WJ, Wang XM, Dai L, Hua X, Dong Z, Schwarz S, Liu S: Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-beta-lactamase gene blaCTX-M-14b. Antimicrob Agents Chemother. 2015 Feb;59(2):1337-40. doi: 10.1128/AAC.04631-14. Epub 2014 Nov 24. [25421479 ]
  26. Li JJ, Spychala CN, Hu F, Sheng JF, Doi Y: Complete nucleotide sequences of bla(CTX-M)-harboring IncF plasmids from community-associated Escherichia coli strains in the United States. Antimicrob Agents Chemother. 2015;59(6):3002-7. doi: 10.1128/AAC.04772-14. Epub 2015 Mar 9. [25753630 ]
  27. Lewandowski EM, Skiba J, Torelli NJ, Rajnisz A, Solecka J, Kowalski K, Chen Y: Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic. Chem Commun (Camb). 2015 Apr 11;51(28):6186-9. doi: 10.1039/c5cc00904a. [25753149 ]
  28. Wang D, Huang X, Chen J, Mou Y, Li H, Yang L: Characterization of genetic structures of the QepA3 gene in clinical isolates of Enterobacteriaceae. Front Microbiol. 2015 Oct 15;6:1147. doi: 10.3389/fmicb.2015.01147. eCollection 2015. [26528280 ]
  29. Matsumura Y, Pitout JD, Gomi R, Matsuda T, Noguchi T, Yamamoto M, Peirano G, DeVinney R, Bradford PA, Motyl MR, Tanaka M, Nagao M, Takakura S, Ichiyama S: Global Escherichia coli Sequence Type 131 Clade with blaCTX-M-27 Gene. Emerg Infect Dis. 2016 Nov;22(11):1900-1907. doi: 10.3201/eid2211.160519. [27767006 ]

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