Heme oxygenase

Name	Heme oxygenase
Synonyms	1.14.14.18
Gene Name	hmuO
Organism	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Amino acid sequence	>lcl\|BSEQ0011993\|Heme oxygenase MTTATAGLAVELKQSTAQAHEKAEHSTFMSDLLEGRLGVAEFTRLQEQAWLFYTALEQAA DAVRASGFAESLLDPALNRAEVLARDLDKLNDGSEWRSRITASPAVIDYVNRLEEIRDNV DGPALVAHHYVRYLGDLSGGQVIARMMQRHYGVDPEALGFYHFEGIAKLKVYKDEYREKL NNLELSDEQRENLLKEATDAFVFNHQVFADLGKGL
Number of residues	None
Molecular Weight	24115.81
Theoretical pI	4.79
GO Classification	Functions heme oxygenase (decyclizing) activity metal ion binding Processes heme oxidation Components
General Function	Metal ion binding
Specific Function	Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P71119
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0011994\|Heme oxygenase (hmuO) ATGACCACTGCAACCGCAGGCCTCGCTGTCGAACTCAAGCAGTCCACCGCACAAGCCCAC GAAAAAGCTGAGCACTCCACCTTCATGAGCGACCTGCTAGAAGGTCGCTTGGGGGTAGCG GAATTTACTCGTCTGCAGGAGCAAGCATGGTTGTTCTACACGGCACTAGAGCAGGCAGCA GATGCCGTGCGTGCCAGCGGATTTGCGGAGTCCCTTCTCGATCCCGCTCTTAACCGTGCT GAGGTTTTGGCACGCGACCTAGACAAGCTCAACGATGGTAGTGAGTGGCGCTCACGCATT ACGGCATCGCCAGCTGTTATCGATTACGTGAATCGTCTTGAAGAAATCCGCGACAATGTT GACGGCCCAGCGCTAGTTGCTCACCACTACGTGCGCTACCTCGGGGATCTCTCGGGCGGA CAGGTTATCGCACGTATGATGCAGCGCCACTACGGCGTTGATCCTGAAGCCCTAGGTTTC TACCACTTCGAGGGGATCGCCAAGCTCAAGGTCTACAAGGATGAGTACCGTGAAAAGCTC AACAACCTAGAGCTTAGCGATGAACAGCGTGAGAACCTTTTGAAAGAAGCAACCGATGCT TTCGTTTTCAACCACCAGGTTTTCGCAGATTTGGGTAAAGGCCTGTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Schmitt MP: Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin. J Bacteriol. 1997 Feb;179(3):838-45. [9006041 ] Cerdeno-Tarraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG, Parkhill J: The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129. Nucleic Acids Res. 2003 Nov 15;31(22):6516-23. [14602910 ]

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