N-acetylneuraminate lyase

Name	N-acetylneuraminate lyase
Synonyms	4.1.3.3 N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase NAL NALase Sialate lyase Sialic acid aldolase Sialic acid lyase
Gene Name	nanA
Organism	Shigella flexneri
Amino acid sequence	>lcl\|BSEQ0011174\|N-acetylneuraminate lyase MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSERE QVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCD HYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRRE HPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECN KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
Number of residues	None
Molecular Weight	32593.23
Theoretical pI	5.69
GO Classification	Functions N-acetylneuraminate lyase activity Processes carbohydrate metabolic process N-acetylneuraminate catabolic process Components cytoplasm
General Function	N-acetylneuraminate lyase activity
Specific Function	Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P0A6L6
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0011175\|N-acetylneuraminate lyase (nanA) ATGGCAACGAATTTACGTGGCGTAATGGCTGCACTCCTGACTCCTTTTGATCAACAACAA GCACTGGATAAAGCGAGTCTGCGCCGCCTGGTTCAGTTCAATATTCAGCAGGGCATCGAC GGTTTATACGTGGGTGGTTCGACCGGCGAAGCCTTTGTACAAAGCCTTTCCGAGCGTGAA CAGGTACTGGAAATCGTCGCCGAAGAGGCGAAAGGTAAGATTAAACTCATCGCCCACGTC GGTTGCGTCAGCACCGCCGAAAGCCAACAACTTGCGGCATCGGCTAAACGTTATGGCTTC GATGCCGTCTCCGCCGTCACGCCGTTCTACTATCCTTTCAGCTTTGAAGAACACTGCGAT CACTATCGGGCAATTATTGATTCAGCGGATGGTTTGCCGATGGTGGTGTACAACATTCCA GCCCTGAGTGGGGTAAAACTGACCCTGGATCAGATCAACACCCTGGTTACGTTGCCTGGC GTCGGTGCGCTGAAACAGACTTCTGGCGATCTCTATCAGATGGAACAGATCCGTCGTGAA CATCCTGATCTGGTGCTCTATAACGGTTACGACGAAATCTTCGCTTCCGGCTTGCTGGCA GGCGCTGATGGTGGTATCGGCAGTACTTACAACATCATGGGCTGGCGATATCAGGGGATC GTGAAGGCGCTGAAAGAAGGCGATATCCAGACCGCGCAGAAACTGCAAACTGAGTGCAAC AAAGTCATTGATTTACTGATCAAAACGGGCGTATTCCGCGGCCTGAAAACTGTCCTGCAT TATATGGATGTCGTTTCTGTGCCGCTGTGCCGCAAACCGTTTGGACCGGTAGATGAAAAA TATCTGCCAGAACTGAAGGCGCTGGCCCAGCAGTTGATGCAAGAGCGCGGGTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [12384590 ] Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [12704152 ]

From www.t3db.ca