L-rhamnose isomerase

Name	L-rhamnose isomerase
Synonyms	5.3.1.14
Gene Name	rhaA
Organism	Escherichia coli (strain K12)
Amino acid sequence	>lcl\|BSEQ0011347\|L-rhamnose isomerase MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVSGFENPEGSLTGGIQ ATGNYPGKARNASELRADLEQAMRLIPGPKRLNLHAIYLESDTPVSRDQIKPEHFKNWVE WAKANQLGLDFNPSCFSHPLSADGFTLSHADDSIRQFWIDHCKASRRVSAYFGEQLGTPS VMNIWIPDGMKDITVDRLAPRQRLLAALDEVISEKLNPAHHIDAVESKLFGIGAESYTVG SNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPQLLLHVSRPVRWDSDHVVL LDDETQAIASEIVRHDLFDRVHIGLDFFDASINRIAAWVIGTRNMKKALLRALLEPTAEL RKLEAAGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPAGSEWLESVRAYEKEILSRRG
Number of residues	None
Molecular Weight	47198.95
Theoretical pI	5.57
GO Classification	Functions manganese ion binding L-rhamnose isomerase activity identical protein binding Processes L-lyxose metabolic process rhamnose catabolic process Components cytoplasm
General Function	Manganese ion binding
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P32170
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0011348\|L-rhamnose isomerase (rhaA) ATGACCACTCAACTGGAACAGGCCTGGGAGCTAGCGAAACAGCGTTTCGCGGCGGTGGGG ATTGATGTCGAGGAGGCGCTGCGCCAACTTGATCGTTTACCCGTTTCAATGCACTGCTGG CAGGGCGATGATGTTTCCGGTTTTGAAAACCCGGAAGGTTCGCTGACCGGGGGGATTCAG GCCACAGGCAATTATCCGGGCAAAGCGCGTAATGCCAGTGAGCTACGTGCCGATCTGGAA CAGGCTATGCGGCTGATTCCGGGGCCGAAACGGCTTAATTTACATGCCATCTATCTGGAA TCAGATACGCCAGTCTCGCGCGACCAGATCAAACCAGAGCACTTCAAAAACTGGGTTGAA TGGGCGAAAGCCAATCAGCTCGGTCTGGATTTTAACCCCTCCTGCTTTTCGCATCCGCTA AGCGCCGATGGCTTTACGCTTTCCCATGCCGACGACAGCATTCGCCAGTTCTGGATTGAT CACTGCAAAGCCAGCCGTCGCGTTTCGGCCTATTTTGGCGAGCAACTCGGCACACCATCG GTGATGAACATCTGGATCCCGGATGGTATGAAAGATATCACCGTTGACCGTCTCGCCCCG CGTCAGCGTCTGCTGGCAGCACTGGATGAGGTGATCAGCGAGAAGCTAAACCCTGCGCAC CATATCGACGCCGTTGAGAGCAAATTGTTTGGCATTGGCGCAGAGAGCTACACGGTTGGC TCCAATGAGTTTTACATGGGGTATGCCACCAGCCGCCAGACTGCGCTGTGCCTGGACGCC GGGCACTTCCACCCGACTGAAGTGATTTCCGACAAGATTTCCGCCGCCATGCTGTATGTG CCGCAGTTGCTGCTGCACGTCAGCCGTCCGGTTCGCTGGGACAGCGATCACGTAGTGCTG CTGGATGATGAAACCCAGGCAATTGCCAGTGAGATTGTGCGTCACGATCTGTTTGACCGG GTGCATATCGGCCTTGACTTCTTCGATGCCTCTATCAACCGCATTGCCGCGTGGGTCATT GGTACACGCAATATGAAAAAAGCCCTGCTGCGTGCGTTGCTGGAACCTACCGCTGAGCTG CGCAAGCTGGAAGCGGCGGGCGATTACACTGCGCGTCTGGCACTGCTGGAAGAGCAGAAA TCGTTGCCGTGGCAGGCGGTCTGGGAAATGTATTGCCAACGTCACGATACGCCAGCAGGT AGCGAATGGCTGGAGAGCGTGCGGGCTTATGAGAAAGAAATTTTGAGTCGCCGCGGGTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Moralejo P, Egan SM, Hidalgo E, Aguilar J: Sequencing and characterization of a gene cluster encoding the enzymes for L-rhamnose metabolism in Escherichia coli. J Bacteriol. 1993 Sep;175(17):5585-94. [8396120 ] Plunkett G 3rd, Burland V, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes. Nucleic Acids Res. 1993 Jul 25;21(15):3391-8. [8346018 ] Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [9278503 ] Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR, Chaudhuri RR, Glasner JD, Horiuchi T, Keseler IM, Kosuge T, Mori H, Perna NT, Plunkett G 3rd, Rudd KE, Serres MH, Thomas GH, Thomson NR, Wishart D, Wanner BL: Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. 2006 Jan 5;34(1):1-9. Print 2006. [16397293 ] Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [16738553 ] Egan SM, Schleif RF: A regulatory cascade in the induction of rhaBAD. J Mol Biol. 1993 Nov 5;234(1):87-98. [8230210 ] Holcroft CC, Egan SM: Roles of cyclic AMP receptor protein and the carboxyl-terminal domain of the alpha subunit in transcription activation of the Escherichia coli rhaBAD operon. J Bacteriol. 2000 Jun;182(12):3529-35. [10852886 ] Korndorfer IP, Fessner WD, Matthews BW: The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. J Mol Biol. 2000 Jul 21;300(4):917-33. [10891278 ]

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