3-oxoacyl-[acyl-carrier-protein] synthase 3

Name3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms
  • 2.3.1.180
  • 3-oxoacyl-[acyl-carrier-protein] synthase III
  • Beta-ketoacyl-ACP synthase III
  • KAS III
  • MtFabH
Gene NamefabH
OrganismMycobacterium tuberculosis
Amino acid sequence
>lcl|BSEQ0051249|3-oxoacyl-[acyl-carrier-protein] synthase 3
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
Number of residuesNone
Molecular Weight34872.13
Theoretical pINone
GO Classification
Functions
  • fatty-acyl-CoA binding
  • 3-oxoacyl-[acyl-carrier-protein] synthase activity
  • beta-ketoacyl-acyl-carrier-protein synthase III activity
Processes
  • fatty acid biosynthetic process
  • lipid biosynthetic process
  • fatty acid elongation
  • long-chain fatty-acyl-CoA metabolic process
Components
  • cytoplasm
General FunctionCatalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall.
Specific Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP9WNG3
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0051250|3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)
ATGACGGAGATCGCCACGACCAGCGGCGCCAGGAGCGTCGGGCTGCTCAGTGTCGGGGCG
TACCGGCCCGAACGCGTGGTCACCAACGACGAGATATGCCAGCACATCGACTCGTCCGAC
GAGTGGATCTACACCCGAACCGGCATCAAGACCCGCCGATTCGCCGCCGACGACGAGTCG
GCGGCTTCCATGGCGACTGAGGCCTGTCGACGGGCACTGTCGAACGCCGGCCTGTCGGCG
GCCGACATCGATGGCGTGATCGTCACCACCAACACCCATTTCCTGCAAACCCCGCCGGCC
GCCCCAATGGTCGCGGCGTCGCTGGGCGCCAAGGGCATACTCGGGTTCGATCTTTCGGCG
GGGTGCGCCGGATTCGGATATGCGCTTGGCGCAGCGGCCGACATGATCCGGGGCGGAGGT
GCGGCCACGATGCTGGTGGTCGGCACGGAAAAACTGTCCCCCACGATAGACATGTACGAC
CGCGGCAACTGCTTCATCTTCGCCGACGGCGCGGCCGCAGTGGTGGTGGGCGAGACACCG
TTTCAAGGCATTGGACCAACCGTGGCGGGTAGCGACGGCGAACAGGCCGATGCCATACGG
CAGGACATCGACTGGATCACTTTCGCCCAGAATCCCAGCGGCCCACGCCCGTTTGTGCGG
CTCGAAGGTCCCGCGGTCTTCCGTTGGGCAGCGTTCAAAATGGGCGACGTCGGTCGGCGC
GCGATGGACGCCGCCGGGGTGCGACCCGACCAGATAGACGTGTTCGTCCCTCATCAGGCC
AATAGCCGCATCAACGAGCTGCTGGTCAAGAACCTGCAGTTGCGGCCCGACGCGGTGGTC
GCCAACGATATCGAGCACACCGGAAACACCTCGGCGGCCTCCATTCCGCTCGCGATGGCC
GAATTACTGACGACCGGCGCGGCCAAGCCCGGCGATCTGGCCCTGTTGATCGGCTACGGC
GCCGGTCTGAGCTATGCCGCCCAGGTGGTGCGAATGCCGAAGGGTTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [9634230 ]
  2. Choi KH, Kremer L, Besra GS, Rock CO: Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem. 2000 Sep 8;275(36):28201-7. [10840036 ]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [19099550 ]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [21969609 ]
  5. Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT: Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem. 2001 Jun 8;276(23):20516-22. Epub 2001 Mar 8. [11278743 ]

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