Acyl-homoserine lactone acylase PvdQ

Name	Acyl-homoserine lactone acylase PvdQ
Synonyms	3.5.1.97 AHL acylase PvdQ qsc112
Gene Name	pvdQ
Organism	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence	>lcl\|BSEQ0012802\|Acyl-homoserine lactone acylase PvdQ MGMRTVLTGLAGMLLGSMMPVQADMPRPTGLAADIRWTAYGVPHIRAKDERGLGYGIGYA YARDNACLLAEEIVTARGERARYFGSEGKSSAELDNLPSDIFYAWLNQPEALQAFWQAQT PAVRQLLEGYAAGFNRFLREADGKTTSCLGQPWLRAIATDDLLRLTRRLLVEGGVGQFAD ALVAAAPPGAEKVALSGEQAFQVAEQRRQRFRLERGSNAIAVGSERSADGKGMLLANPHF PWNGAMRFYQMHLTIPGRLDVMGASLPGLPVVNIGFSRHLAWTHTVDTSSHFTLYRLALD PKDPRRYLVDGRSLPLEEKSVAIEVRGADGKLSRVEHKVYQSIYGPLVVWPGKLDWNRSE AYALRDANLENTRVLQQWYSINQASDVADLRRRVEALQGIPWVNTLAADEQGNALYMNQS VVPYLKPELIPACAIPQLVAEGLPALQGQDSRCAWSRDPAAAQAGITPAAQLPVLLRRDF VQNSNDSAWLTNPASPLQGFSPLVSQEKPIGPRARYALSRLQGKQPLEAKTLEEMVTANH VFSADQVLPDLLRLCRDNQGEKSLARACAALAQWDRGANLDSGSGFVYFQRFMQRFAELD GAWKEPFDAQRPLDTPQGIALDRPQVATQVRQALADAAAEVEKSGIPDGARWGDLQVSTR GQERIAIPGGDGHFGVYNAIQSVRKGDHLEVVGGTSYIQLVTFPEEGPKARGLLAFSQSS DPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQLQRLSIRE
Number of residues	None
Molecular Weight	84039.305
Theoretical pI	7.1
GO Classification	Functions hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides N-acetyl-anhydromuramoyl-L-alanine amidase activity Processes quorum sensing antibiotic biosynthetic process Components periplasmic space
General Function	N-acetyl-anhydromuramoyl-l-alanine amidase activity
Specific Function	Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q9I194
UniProtKB Entry Name
Cellular Location	Periplasm
Gene sequence	>lcl\|BSEQ0012803\|Acyl-homoserine lactone acylase PvdQ (pvdQ) ATGGGGATGCGTACCGTACTGACCGGCCTGGCCGGCATGCTGTTGGGTTCGATGATGCCG GTCCAGGCCGATATGCCGCGGCCGACCGGGCTGGCCGCGGATATCCGCTGGACCGCCTAT GGCGTGCCGCACATCCGGGCCAAGGATGAGCGCGGCCTGGGCTATGGCATCGGCTACGCC TACGCGCGCGACAACGCCTGCCTGCTGGCCGAGGAGATCGTCACCGCGCGCGGCGAGCGG GCGCGCTATTTCGGCAGCGAGGGCAAGTCGTCGGCCGAGCTGGACAACCTGCCGTCCGAC ATCTTCTACGCCTGGCTCAACCAACCCGAGGCGCTGCAAGCCTTCTGGCAGGCGCAGACG CCCGCGGTACGCCAGTTGCTCGAAGGCTACGCCGCCGGTTTCAACCGCTTCCTCCGCGAG GCCGACGGCAAGACCACCAGTTGCCTTGGCCAGCCCTGGCTGCGGGCCATCGCGACCGAT GACCTGCTGCGCCTGACCCGGCGCCTGCTGGTCGAAGGCGGGGTCGGCCAGTTCGCCGAC GCGCTGGTGGCCGCCGCGCCGCCCGGAGCGGAGAAGGTCGCCTTGAGCGGCGAGCAGGCG TTCCAGGTCGCCGAGCAGCGGCGCCAGCGCTTCCGCCTGGAGCGCGGCAGCAACGCCATT GCCGTTGGCAGCGAACGTTCGGCGGACGGCAAGGGCATGCTCCTGGCCAACCCGCACTTC CCCTGGAACGGCGCGATGCGTTTCTACCAGATGCACCTGACCATTCCCGGCCGGCTCGAC GTGATGGGGGCCTCGCTGCCCGGCCTGCCGGTGGTCAACATCGGCTTCAGCCGCCACCTG GCCTGGACCCACACGGTGGATACCTCCAGCCACTTCACCCTGTATCGCCTGGCGCTGGAC CCGAAGGACCCGCGGCGCTACCTGGTCGACGGTCGTTCGCTGCCGCTGGAGGAGAAGTCC GTCGCGATCGAGGTGCGCGGCGCCGACGGCAAGCTGTCGCGCGTCGAGCACAAGGTCTAC CAGTCGATCTACGGCCCGCTGGTGGTCTGGCCCGGCAAGCTGGACTGGAACCGCAGCGAG GCCTATGCGCTGCGTGACGCCAACCTGGAGAACACCCGGGTACTGCAACAGTGGTACTCG ATCAACCAGGCCAGCGACGTCGCCGACCTGCGCCGGCGCGTCGAGGCGCTACAGGGGATC CCCTGGGTCAACACCCTGGCCGCGGACGAGCAGGGCAACGCCCTGTACATGAACCAGTCG GTGGTGCCCTACCTGAAGCCGGAACTGATTCCCGCCTGCGCCATTCCGCAACTGGTCGCC GAAGGCCTGCCGGCCCTCCAGGGGCAGGACAGCCGCTGTGCCTGGAGTCGCGACCCGGCC GCGGCCCAGGCTGGCATCACCCCGGCGGCGCAACTGCCGGTGCTGTTGCGCAGGGACTTC GTGCAGAACTCCAACGACAGCGCCTGGCTGACCAACCCGGCGAGCCCGCTGCAGGGCTTC TCGCCCCTGGTCAGCCAGGAGAAGCCCATCGGTCCGCGGGCGCGCTACGCCCTGAGCCGG CTACAGGGCAAGCAGCCGCTGGAGGCGAAGACGCTCGAGGAGATGGTCACCGCCAACCAT GTCTTCAGCGCCGACCAGGTGCTGCCGGACCTGCTCCGCCTGTGCCGCGACAACCAGGGC GAGAAGTCCCTTGCCCGCGCCTGCGCGGCCCTGGCGCAGTGGGACCGTGGCGCCAACCTC GACAGCGGCAGCGGCTTCGTCTACTTCCAGCGCTTCATGCAACGCTTCGCCGAACTCGAC GGCGCGTGGAAGGAACCGTTCGATGCGCAACGTCCCCTGGATACGCCGCAAGGCATCGCC CTCGACCGGCCGCAGGTGGCGACCCAGGTGCGCCAGGCGCTGGCGGACGCGGCGGCGGAG GTGGAGAAGAGCGGGATTCCCGACGGCGCGCGCTGGGGCGACCTGCAAGTGAGCACCCGT GGCCAGGAACGCATCGCGATTCCCGGCGGCGATGGCCATTTCGGGGTCTACAACGCGATC CAGAGCGTCCGCAAGGGCGACCACCTGGAGGTGGTCGGCGGCACTAGCTACATCCAGCTG GTGACCTTCCCCGAGGAAGGGCCCAAGGCTCGCGGGTTGCTGGCTTTCTCCCAGTCCAGC GATCCGCGCTCGCCGCACTACCGCGACCAGACCGAGCTGTTTTCCCGCCAGCAATGGCAG ACCTTGCCGTTCAGCGACAGGCAGATCGACGCCGACCCGCAACTGCAACGGCTAAGCATT CGCGAATGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [10984043 ] Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Camara M, Williams P, Quax WJ: Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun. 2006 Mar;74(3):1673-82. [16495538 ] Ochsner UA, Wilderman PJ, Vasil AI, Vasil ML: GeneChip expression analysis of the iron starvation response in Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes. Mol Microbiol. 2002 Sep;45(5):1277-87. [12207696 ] Huang JJ, Han JI, Zhang LH, Leadbetter JR: Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1. Appl Environ Microbiol. 2003 Oct;69(10):5941-9. [14532048 ] Lamont IL, Martin LW: Identification and characterization of novel pyoverdine synthesis genes in Pseudomonas aeruginosa. Microbiology. 2003 Apr;149(Pt 4):833-42. [12686626 ]

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