Trimethylamine dehydrogenase

Name	Trimethylamine dehydrogenase
Synonyms	1.5.8.2 TMADh
Gene Name	tmd
Organism	Methylophilus methylotrophus
Amino acid sequence	>lcl\|BSEQ0012125\|Trimethylamine dehydrogenase MARDPKHDILFEPIQIGPKTLRNRFYQVPHCIGAGSDKPGFQSAHRSVKAEGGWAALNTE YCSINPESDDTHRLSARIWDEGDVRNLKAMTDEVHKYGALAGVELWYGGAHAPNMESRAT PRGPSQYASEFETLSYCKEMDLSDIAQVQQFYVDAAKRSRDAGFDIVYVYGAHSYLPLQF LNPYYNKRTDKYGGSLENRARFWLETLEKVKHAVGSDCAIATRFGVDTVYGPGQIEAEVD GQKFVEMADSLVDMWDITIGDIAEWGEDAGPSRFYQQGHTIPWVKLVKQVSKKPVLGVGR YTDPEKMIEIVTKGYADIIGCARPSIADPFLPQKVEQGRYDDIRVCIGCNVCISRWEIGG PPMICTQNATAGEEYRRGWHPEKFRQTKNKDSVLIVGAGPSGSEAARVLMESGYTVHLTD TAEKIGGHLNQVAALPGLGEWSYHRDYRETQITKLLKKNKESQLALGQKPMTADDVLQYG ADKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLTPEQVMDGKKKIGKRVVILNADTY FMAPSLAEKLATAGHEVTIVSGVHLANYMHFTLEYPNMMRRLHELHVEELGDHFCSRIEP GRMEIYNIWGDGSKRTYRGPGVSPRDANTSHRWIEFDSLVLVTGRHSECTLWNELKARES EWAENDIKGIYLIGDAEAPRLIADATFTGHRVAREIEEANPQIAIPYKRETIAWGTPHMP GGNFKIEYKV
Number of residues	None
Molecular Weight	81628.615
Theoretical pI	6.31
GO Classification	Functions FMN binding metal ion binding 4 iron, 4 sulfur cluster binding trimethylamine dehydrogenase activity Processes Components
General Function	Trimethylamine dehydrogenase activity
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P16099
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0005925\|2193 bp ATGGCACGAGATCCGAAGCATGATATTTTGTTTGAGCCAATACAAATTGGCCCCAAAACA TTACGCAATCGCTTTTACCAGGTACCGCATTGTATCGGTGCTGGATCCGATAAGCCTGGC TTTCAATCTGCACACCGTTCGGTTAAAGCTGAAGGCGGTTGGGCGGCTTTAAACACTGAA TATTGCTCCATTAACCCTGAGTCAGATGATACACATCGTTTGTCCGCACGTATCTGGGAC GAAGGTGATGTGCGTAACTTGAAAGCCATGACCGACGAAGTTCATAAGTACGGTGCATTA GCCGGGGTCGAGTTATGGTACGGCGGTGCACACGCACCTAACATGGAGTCACGCGCGACC CCACGTGGTCCAAGCCAATATGCGTCAGAGTTTGAGACGCTGTCCTACTGTAAAGAAATG GATCTAAGCGATATCGCTCAGGTACAGCAGTTCTATGTTGATGCAGCGAAGCGCTCTCGT GACGCTGGTTTTGACATTGTCTACGTATACGGTGCGCACTCTTATTTGCCGCTGCAATTC CTGAATCCATACTACAACAAGCGTACAGACAAATACGGTGGCTCATTGGAGAACCGTGCG CGCTTCTGGCTGGAAACACTAGAAAAAGTGAAGCATGCCGTGGGTTCAGATTGTGCGATT GCGACACGTTTCGGCGTGGATACTGTGTATGGTCCAGGTCAAATCGAAGCAGAAGTGGAT GGTCAGAAGTTTGTTGAAATGGCTGACTCACTGGTCGATATGTGGGATATCACAATTGGT GATATTGCCGAGTGGGGCGAAGATGCGGGGCCGTCACGTTTCTACCAGCAAGGTCACACC ATCCCTTGGGTTAAATTGGTCAAACAGGTTTCCAAAAAACCAGTATTAGGCGTTGGCCGT TATACCGACCCTGAGAAAATGATCGAAATCGTCACCAAAGGCTATGCCGACATTATTGGT TGTGCACGCCCTTCTATTGCTGATCCGTTCTTGCCACAAAAGGTTGAGCAGGGTCGCTAC GACGATATCCGTGTATGTATTGGTTGTAACGTGTGTATTTCCCGCTGGGAAATCGGTGGT CCTCCAATGATTTGTACCCAGAATGCGACAGCAGGTGAAGAGTACCGTCGTGGTTGGCAT CCAGAGAAATTCCGTCAAACCAAGAACAAGGATTCTGTATTGATCGTTGGTGCAGGCCCA TCCGGTTCTGAAGCAGCCCGCGTATTGATGGAAAGCGGTTATACCGTGCACTTGACCGAT ACCGCAGAGAAAATCGGTGGTCACTTGAACCAGGTGGCAGCGTTGCCTGGCTTGGGTGAG TGGAGCTATCACCGCGATTATCGTGAAACACAAATCACCAAGTTGCTGAAGAAGAACAAA GAAAGCCAATTGGCATTGGGTCAAAAACCAATGACGGCTGACGACGTGCTGCAATATGGT GCTGACAAAGTCATCATCGCTACCGGTGCGCGCTGGAATACCGATGGTACCAACTGCCTG ACGCATGACCCAATTCCAGGGGCAGATGCTTCCTTGCCAGATCAACTGACACCAGAGCAA GTCATGGATGGTAAGAAGAAGATTGGTAAGCGCGTGGTGATTCTGAATGCGGATACTTAT TTCATGGCGCCTAGCCTGGCTGAGAAGCTTGCGACGGCTGGTCACGAAGTAACCATCGTT TCTGGCGTGCACCTGGCTAACTACATGCACTTCACGCTGGAATATCCAAACATGATGCGT CGTTTGCACGAACTGCATGTTGAAGAGTTGGGCGATCACTTCTGCTCACGTATCGAACCA GGCCGTATGGAAATCTACAACATCTGGGGCGATGGTTCCAAACGTACTTACCGTGGCCCA GGCGTTTCTCCGCGTGATGCCAATACCTCGCATCGTTGGATTGAGTTTGACTCCCTGGTG CTGGTGACAGGCCGTCATTCAGAGTGCACGCTGTGGAATGAGTTAAAAGCCCGTGAATCT GAGTGGGCTGAGAACGACATTAAAGGTATCTACCTGATTGGTGATGCTGAGGCGCCTCGT TTGATTGCTGATGCCACATTTACGGGTCACCGTGTGGCCCGTGAAATTGAAGAAGCAAAC CCACAAATTGCCATCCCATACAAGCGTGAAACCATCGCATGGGGCACGCCGCATATGCCA GGTGGTAATTTCAAAATTGAGTACAAAGTTTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Boyd G, Mathews FS, Packman LC, Scrutton NS: Trimethylamine dehydrogenase of bacterium W3A1. Molecular cloning, sequence determination and over-expression of the gene. FEBS Lett. 1992 Aug 24;308(3):271-6. [1505666 ] Kenney WC, McIntire W, Steenkamp DJ: Amino acid sequence of a cofactor peptide from trimethylamine dehydrogenase. FEBS Lett. 1978 Jan 1;85(1):137-40. [620783 ] Barber MJ, Neame PJ, Lim LW, White S, Matthews FS: Correlation of x-ray deduced and experimental amino acid sequences of trimethylamine dehydrogenase. J Biol Chem. 1992 Apr 5;267(10):6611-9. [1551870 ] Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS: Extensive conformational sampling in a ternary electron transfer complex. Nat Struct Biol. 2003 Mar;10(3):219-25. [12567183 ]

From www.t3db.ca