Morphinone reductase

Name	Morphinone reductase
Synonyms
Gene Name	morB
Organism	Pseudomonas putida
Amino acid sequence	>lcl\|BSEQ0022314\|Morphinone reductase MPDTSFSNPGLFTPLQLGSLSLPNRVIMAPLTRSRTPDSVPGRLQQIYYGQRASAGLIIS EATNISPTARGYVYTPGIWTDAQEAGWKGVVEAVHAKGGRIALQLWHVGRVSHELVQPDG QQPVAPSALKAEGAECFVEFEDGTAGLHPTSTPRALETDEIPGIVEDYRQAAQRAKRAGF DMVEVHAANACLPNQFLATGTNRRTDQYGGSIENRARFPLEVVDAVAEVFGPERVGIRLT PFLELFGLTDDEPEAMAFYLAGELDRRGLAYLHFNEPDWIGGDITYPEGFREQMRQRFKG GLIYCGNYDAGRAQARLDDNTADAVAFGRPFIANPDLPERFRLGAALNEPDPSTFYGGAE VGYTDYPFLDNGHDRLG
Number of residues	None
Molecular Weight	41249.71
Theoretical pI	4.67
GO Classification	Functions FMN binding oxidoreductase activity Processes Components
General Function	Oxidoreductase activity
Specific Function	None
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q51990
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0005929\|1134 bp ATGCCGGATACATCCTTCTCCAACCCCGGGCTCTTCACCCCGCTGCAGCTGGGCAGCCTC AGCCTGCCCAACCGCGTGATCATGGCGCCGCTGACCCGCTCGCGCACGCCGGACAGCGTT CCCGGCAGGTTGCAGCAGATCTACTATGGCCAGCGCGCCAGCGCCGGGCTGATCATCAGC GAGGCCACCAATATCTCGCCCACCGCCCGCGGCTACGTCTACACGCCGGGGATCTGGACC GACGCGCAGGAAGCCGGCTGGAAGGGCGTCGTCGAGGCGGTGCATGCCAAGGGCGGGCGC ATCGCCCTGCAGCTGTGGCACGTCGGCCGTGTCTCCCACGAGCTGGTGCAGCCCGACGGC CAGCAGCCCGTGGCACCGAGCGCCCTCAAGGCCGAGGGGGCGGAATGCTTCGTCGAGTTC GAGGACGGCACGGCGGGGCTGCACCCCACCAGCACGCCGCGGGCGCTTGAGACCGACGAG ATCCCCGGCATCGTCGAGGACTACCGCCAGGCTGCGCAGCGCGCCAAGCGTGCCGGCTTC GACATGGTCGAGGTCCACGCCGCCAACGCCTGCCTGCCCAACCAGTTCCTCGCCACCGGC ACCAACCGGCGCACCGACCAGTACGGCGGCTCCATCGAGAACCGGGCGCGCTTCCCGCTG GAGGTGGTCGACGCCGTGGCCGAGGTGTTCGGGCCCGAGCGGGTCGGCATCCGCCTGACC CCCTTCCTCGAGCTCTTCGGCCTCACCGACGACGAGCCCGAGGCGATGGCCTTCTACCTG GCCGGCGAGCTCGACCGCCGCGGCCTGGCCTACCTCCACTTCAACGAGCCCGACTGGATC GGTGGCGATATCACCTACCCCGAAGGCTTCCGGGAGCAGATGCGCCAGCGCTTCAAGGGT GGGCTGATCTACTGCGGCAACTACGATGCCGGGCGCGCCCAGGCCCGCCTGGATGACAAC ACCGCCGACGCCGTGGCCTTCGGCCGCCCCTTCATCGCCAACCCCGATCTGCCCGAGCGC TTCCGCCTGGGGGCCGCCCTCAACGAGCCCGACCCCAGCACCTTCTACGGCGGCGCCGAG GTCGGCTACACCGACTACCCCTTCCTCGACAACGGCCACGACCGGCTCGGCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Barna T, Messiha HL, Petosa C, Bruce NC, Scrutton NS, Moody PC: Crystal structure of bacterial morphinone reductase and properties of the C191A mutant enzyme. J Biol Chem. 2002 Aug 23;277(34):30976-83. Epub 2002 Jun 4. [12048188 ] Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS: Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. J Am Chem Soc. 2007 Nov 14;129(45):13949-56. Epub 2007 Oct 16. [17939663 ] Pudney CR, McGrory T, Lafite P, Pang J, Hay S, Leys D, Sutcliffe MJ, Scrutton NS: Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure. Chembiochem. 2009 May 25;10(8):1379-84. doi: 10.1002/cbic.200900071. [19405065 ]

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